Optimal design for population PK/PD models

In: Tatra Mountains Mathematical Publications, vol. 51, no. 1

Sergei Leonov - Alexander Aliev

Details:

Year, pages: 2012, 115 - 130

Keywords:

optimal model-based design; Fisher information matrix; $D$-optimality, PK/PD models, compartmental models

About article:

We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

How to cite:

ISO 690:

Leonov, S., Aliev, A. 2012. Optimal design for population PK/PD models. In Tatra Mountains Mathematical Publications, vol. 51, no.1, pp. 115-130. 1210-3195.

APA:

Leonov, S., Aliev, A. (2012). Optimal design for population PK/PD models. Tatra Mountains Mathematical Publications, 51(1), 115-130. 1210-3195.