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Institute: Centre of Biosciences SAS

Bacteriocins and their benefits in reduction of spoilage, biofilm-producing bacteria from food products and food industry environment
Bakteriocíny a ich prospešnosť pri redukcii nežiaducich, biofilm-produkujúcich baktérií z potravín a z prostredia ich výroby
Program: Bilateral - other
Project leader: MVDr. Lauková Andrea CSc.
Annotation:Food safety but also hygiene and safety of food industry environment are of prime concern to both, industry and consumers. In fact food security depends on food safety and control of food spoilage. The most inspected regarding these aims are products of dairy and meat industry. In spite of the maintaining all ISO rules and HACCP rules, contamination can occur in the food chain from roducer to consumer and the consequence is a decrease of the product quality. At recent time, the frequent studies are related to problems with biofilm-producing bacteria; they are in biofilm which is protective for them; it means they are more resistant to survive. This project therefore will solve use and benefit of bacteriocins (antimicrobial substances produced by some bacteria) to reduce spoilage biofilm-producing bacteria from food and food industry environment.
Duration: 1.1.2019 - 31.12.2020

Bacteriocins, a safe way to inhibit antibiotic resistant bacteria from pigs for healthy farming
Bakteriocíny, bezpečný spôsob redukovania na antibiotiká rezistentné baktérie pre zachovanie zdravého chovu prasiat
Program: Bilateral - other
Project leader: MVDr. Lauková Andrea CSc.
Annotation:In Serbia, pigs production is related to commercial farms, family farms type A and B, backyard holding and free-range animals. The majority of farmers is facing with different health issues in herds, financial difficulties and not able to overcome the problems in the production. Their production strategies often rely to antimicrobial therapy. As a consequence, different groups od ATB have wide application at pig farms as prophylactic and therapeutic measure; it leads to the development of resitant microbiota in herd population. Antimicrobial resistance has emerged as major clinical and public health concern due to its negative effects reflected in prolonged, complicated therapy course and inadequate control of spreading resistant bacteria. That is necessary to find strategy how to reduce this atb pressure. One promising way how to stop/reduce ATb resistant bacteria represent bacteriocins. They are substances of proteinacoeus character with antimicrobial effect against more or less relative bacteria. In this project inhibition activity of bacteriocins/enterocins (produced by probiotic E. faecium strains from SK) against especially to ATB resistant coliforms isolated from pigs will be tested with the aim to find a new strategy to reduce antibiotic resistant strains in breeding. This is original and perspective method which brings benefit for both partners; for healthy farming and for study antimicrobial spectrum of enterocins.
Duration: 15.2.2019 - 31.12.2020

Barth syndrome - Study of mitochondrial morphology in a novel yeast model.
Barthov syndróm - Štúdium morfológie mitochondrií v novom kvasinkovom modeli.
Program: Inter-academic agreement
Project leader: Mgr. Balážová Mária PhD.
Annotation:Barth syndrome (BTHS) is a serious hereditary mitochondrial disorder characterized by a decrease in total cardiolipin (CL) and in accumulation of its precursor monolyso-CL due to the loss of transacylase tafazzin. The molecular basis underlying the pathology of BTHS is still not well understood. The aim of this project is to characterize a novel yeast model of BTHS (pgc1∆taz1∆ double mutant) and its use in studies focused on the role of different lipids (phospholipids and sphingolipids) in mitochondrial morphology. We suppose that this yeast model system will highly enhance the capacity to identify molecular mechanisms by which changes in membrane lipids lead to defects in mitochondrial functions and morphology not only in BTHS but also in other mitochondrial disorders.
Duration: 1.1.2018 - 31.12.2020

Brillouin Light Scattering Microspectroscopy for Biological and Biomedical Research and Applications.
Brillouinova svetelná mikrospektrometria v biologickom a biomedicínskom základnom a aplikovanom výskume
Program: FP5
Project leader: Mgr. Bágeľová Poláková Silvia PhD.
Duration: 28.2.2017 - 27.2.2021

Brillouin Light Scattering Microspectroscopy for Biological and Biomedical Research and Applications.
Brillouinova svetelná mikrospektrometria v biologickom a biomedicínskom základnom a aplikovanom výskume.
Program: COST
Project leader: Mgr. Bágeľová Poláková Silvia PhD.
Annotation:This BioBrillouin Action will establish a collaborative network of European researchers and instrument developers working in the field of Brillouin Light Scattering Spectroscopy (BLSS) applied to life sciences and health related problems. BLSS uses visible or infrared light from a laser source to probe the mechanics of a material through light scattering from thermally induced acoustic modes. It can give access to the viscoelasticity and structure of matter in a non-destructive contactless way, and when coupled to optical (confocal) microscopy, has proven to be particularly well suited for biomedical applications. Though an established tool in condensed matter physics, only more recently has BLSS seen promising applications in the life sciences and medical diagnostics. This can largely be attributed to advances in instrument (spectrometer) design coupled with increasing interest in the biomechanics of cells and tissues and their relation to disease, underlying genetics and biochemistry. There are now a significant and increasing number of researchers actively working in BLSS for biomedical research in Europe. It is the aim of the BioBrillouin Action to for the first time bring together the diverse community working in the field, which includes instrument developers, physicists, chemists, biologists and clinicians, with the core aim of stimulating collaboration, promoting technological advancement and paving the way towards routine life science research and clinical applications of BLSS.
Duration: 28.2.2017 - 27.2.2021

Identifying causes and solutions of keel bone damage in laying hens
Identifikácia príčin a riešení poškodenia hrebeňa prsnej kosti u nosníc
Program: COST
Project leader: RNDr. Košťál Ľubor CSc.
Annotation:The KeelBoneDamage COST Action will provide the European laying hen industry with the innovations in breeding, nutrition, and management necessary to resolve the problem of Keel bone damage (KBD) in order to meet the high standards of welfare and productivity demanded by the European community.The extremely high frequency and severity of KBD represents one of the greatest welfare problems facing the industry as suggested by several of the leading authorities in animal welfare, including the UK`s Farm Animal Welfare Committee and EFSA. More critically, KBD appears to be exacerbated by recent transitions imposed by EU legislation which banned the use of conventional battery cages from January 2012. Although conceived with the best of intentions and a bold step to improve hen welfare, the unexpected consequences are a blight on Europe`s moral standing and as a result of this well-intended legislation, the laying hen industry is now faced with the unexpected challenge of greatly increased KBD leading to reduced animal welfare and farm productivity. The proposed framework seeks to provide a platform for collaboration on the the causes of KBD and solutions to reduce their severity and frequency. The Action brings various participants with a diverse mix of disciplines, ages, and geographies together to facilitate novel and trans-disciplinary discussions that will lead to definitive and quantifiable outputs. Advancements will be performed in concert with industrial partners whom are leaders in the field ensuring that developments are directed into tangible outputs that improve animal welfare and farm productivity.
Duration: 18.10.2016 - 17.10.2020

Lipid metabolisms as a crucial regulator of mitochondrial function
Metabolizmus lipidov ako kľúčový regulátor mitochondriálnej funkcie
Program: Bilateral - other
Project leader: Mgr. Balážová Mária PhD.
Annotation:Barth syndrome (BTHS) is a serious hereditary mitochondrial disorder characterized by a decrease in total cardiolipin (CL) and in accumulation of its precursor monolyso-CL due to the loss of transacylase tafazzin. The molecular basis underlying the pathology of BTHS is still not well understood. The aim of this project is characterization of a new yeast model of BTHS (pgc1taz1 double mutant) and its use for study of the role of different lipids, phospholipids and sphingolipids, on mitochondrial morphology, function, and reactive oxygen species production. Parallel experiments will be conducted in collaboration with the Taiwanese partner on human BTHS model (taz of HAP1 human haploid cells generated by CRISPR/Cas9 system). Combined use of a yeast model and human cell line system will highly enhance the capacity to identify molecular mechanism how changes in membrane lipids lead to defects in mitochondrial functions and morphology not only in BTHS but also in other mitochondrial disorders.
Duration: 1.3.2017 - 28.2.2020

Benefits of bacteriocins application in horse diet
Prospešnosť aplikácie bakteriocínov v diéte koní
Program: Inter-academic agreement
Project leader: MVDr. Lauková Andrea CSc.
Annotation:The aim of the project is to study the possible beneficial effect of enterocins on horse breeds in Slovakia/Poland. The natural substances (provided by the Slovak partner) will be used to maintain healthy conditions in horses. In the study microbiota, hematology, biochemistry, phagocytic and enzymatic/metabolic activity parameters will be analysed. In addition, it will be possible to isolate a new active bacteriocin from faecal samples of horses from Poland. The scientific area of the study is actual, only limited information is available regarding the horses microbiota and the effect of bacteriocins on the physiological parameters in those animals.The expected results will be the principal contribution to the knowledge of horses microbiota (also their welfare and health) which is still limited. Apart from enterocins analyses and their usefulness in horses we will perform detail sequencing of the faecal samples to distinguish microbiota profile from phyla to the species occurrence which will allow to extent the present knowledge in this field.
Duration: 1.1.2019 - 31.12.2021

Synergy for preventing damaging behaviour in group housed pigs and chickens
Synergia pre zabránenie poškodzujúcemu správaniu u skupinovo chovaných ošípaných a nosníc
Program: COST
Project leader: RNDr. Košťál Ľubor CSc.
Annotation:The GroupHouseNet aim is to provide the European livestock industry with innovations in breeding and management for pigs and poultry that are needed for a successful transition to large group housing systems without necessitating painful tail docking and beak trimming. Allowing the animals greater opportunities to display their species-specific behaviour while avoiding the routine use of painful procedures, group housing of unmutilated animals sits at the core of the new animal welfare paradigm driven by consumer demand. Group housing is associated with increased risks of damaging behaviours among the animals, such as feather pecking, aggression and cannibalism in laying hens and tail biting, bellynosing, excessive aggression and cannibalism in pigs. Recent research suggests the key to reducing the incidence of these behaviours lies in refining and applying methods of genetic selection, and developing husbandry innovations that improve early and later life conditions - which is exactly what GroupHouseNet will use the COST Action framework and tools to do. GroupHouseNet brings together researchers and industrial partners dealing with animal breeding and genetics, animal nutrition, epidemiology, engineering, animal behaviour and welfare, epigenetics, immunology, (neuro)physiology, economics and ethics. To strengthen the scientific and technological basis in these areas the Action will facilitate knowledge sharing, creation and application in pigs and laying hens in both experimental and commercial environments. The activities will be conducted in an open, output-oriented transnational, multisectorial, and multidisciplinary research and development network emphasising COST Excellence and Inclusiveness Policy.
Duration: 2.3.2016 - 1.3.2020

Study of molecules involved in fertilization process of mammals
Štúdium molekúl zúčastnených vo fertilizačnom procese cicavcov
Program: Inter-academic agreement
Project leader: Ing. Jankovičová Jana PhD.
Duration: 1.1.2018 - 31.12.2020

Exploring the molecular determinants and functional role of T-type channel dimerization
Výskum molekulárnych determinantov a funkčných dôsledkov dimerizácie T-typu vápnikových kanálov
Program: Inter-academic agreement
Project leader: prof. RNDr. Lacinová Ľubica DrSc.
Annotation:Low-voltage-activated T-type calcium channels are essential contributors to neuronal physiology where they play fundamentally important roles in shaping excitability of nerve cells and neurotransmission. Aberrant neuronal excitability caused by alteration of T-type channel expression has been linked to a number of neuronal disorders including absence epilepsy and neuropathic pain. Hence, there is increased interest in identifying the mechanisms controlling the expression and functioning of T-type channels in normal and pathological conditions. In the recent past, association of T-type channels with other ion channel family members has emerged as an important mechanism to control their functioning. The goal of the proposed research project is to further explore the role of channel signaling complexes, and elucidate the importance of T-type channel homodimerization in the expression and functioning of the channel.
Duration: 1.1.2018 - 31.12.2020

The total number of projects: 11