Optimal design for population PK/PD models

In: Tatra Mountains Mathematical Publications, vol. 51, no. 1

Sergei Leonov - Alexander Aliev

Detaily:

Rok, strany: 2012, 115 - 130

Kľúčové slová:

optimal model-based design; Fisher information matrix; $D$-optimality, PK/PD models, compartmental models

O článku:

We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

Ako citovať:

ISO 690:

Leonov, S., Aliev, A. 2012. Optimal design for population PK/PD models. In Tatra Mountains Mathematical Publications, vol. 51, no.1, pp. 115-130. 1210-3195.

APA:

Leonov, S., Aliev, A. (2012). Optimal design for population PK/PD models. Tatra Mountains Mathematical Publications, 51(1), 115-130. 1210-3195.