In: General Physiology and Biophysics, vol. 27, no. 1
K. Ondrias - L. Malekova - O. Krizanova
Details:
Year, pages: 2008, 38 - 44
About article:
Mitochondrial membranes isolated from a rat heart muscle were incorporated into a bilayer lipid membrane (BLM) and channel currents were measured in 250/50 mmol/l KCl cis/trans solutions. The channel currents measured from −40 to +40 mV had various linear voltage-current relationships and K+/Cl– permeability ratios at distinct voltage ranges. The channels possessed K+-Cl– promiscuous property. Depending on voltage, membrane permeability suddenly switched from K+ over Cl– to Cl– over K+ and back. The channels had Cl–/K+ > 1 permeability at potentials around 0 mV and the permeability was switched to K+/Cl– > 1 at more negative and positive potentials. The chloride channel blocker, 5-nitro-2-(phenylpropylamino)-benzoate (NPPB, 5 × 10–5 mol/l), influenced properties of the promiscuous channels – it activated potassium conductance of the channels.
How to cite:
ISO 690:
Ondrias, K., Malekova, L., Krizanova, O. 2008. Potassium-chloride promiscuous channels in mitochondrial membranes. In General Physiology and Biophysics, vol. 27, no.1, pp. 38-44. 0231-5882.
APA:
Ondrias, K., Malekova, L., Krizanova, O. (2008). Potassium-chloride promiscuous channels in mitochondrial membranes. General Physiology and Biophysics, 27(1), 38-44. 0231-5882.