In: General Physiology and Biophysics, vol. 30, no. 4
Ľubica Lacinová
Details:
Year, pages: 2011, 403 - 409
About article:
Since cloning of the T-type or CaV 3.n calcium channel family in 1998–1999 much progress was made in investigation of their regulation. Most effective metal CaV 3 channel blockers are trivalent cations from lanthanide group together with transition metals La3+ and Y3+. Divalent cations Zn2+, Cu2+ and Ni2+ inhibit CaV 3.2 channels more efficiently than CaV 3.1 and CaV 3.3 channels via second high-affinity binding site including histidine H191 specific for the CaV 3.2 channel. Dihydropyridines and phenylalkylamines in addition to block of L-type calcium channel can inhibit CaV 3 channels in clinically relevant concentration.
How to cite:
ISO 690:
Lacinová, Ľ. 2011. T-type calcium channel blockers – new and notable. In General Physiology and Biophysics, vol. 30, no.4, pp. 403-409. 0231-5882.
APA:
Lacinová, Ľ. (2011). T-type calcium channel blockers – new and notable. General Physiology and Biophysics, 30(4), 403-409. 0231-5882.