D-dimer, plasminogen activator inhibitor-1, prothrombin fragments and protein C – role in prothrombotic state of colorectal cancer.

Year, pages: 2011, 235 - 238

The relationship between malignant tumors and blood coagulation disorders is generally well known. The authors studied blood coagulation in patients with colorectal cancer and evaluated some prothrombotic markers. <br />The authors analyzed by latex-aglutination method, ProC Global test, Asserachrom PAI-1 test and Enzygnost F 1+2 test the group of 137 patients with malignant tumor of colon and rectum, drew attention to the relationship between level of D-dimer, PAI-1, F 1+2, Protein C and the progress of malignant tumor, its localization, clinical stage, histopathology type, method of surgery considering the stapling use. <br />Very aggressive and advanced tumors have significantly higher level of D-dimer, plasminogen activator inhibitor I (PAI-1). Prothrombotic fragments 1+2 were significantly higher by anastomosis dehiscence. Protein C level was lower in the age from sixty to seventy and in advanced clinical stage. <br />Pre-operative surveys of D-dimer, PAI-1, prothrombotic fragments and Protein C give informations about risk of thrombosis of malignant diseases, their clinical stage and histological type. D-dimer and PAI-1 have a real clinical value and can be reliable prothrombotic marker. Keywords: colorectal cancer, hypercoagulation,D-dimers, plasminogen activator inhibitor, protein C

Mytnik, M., Stasko, J. 2011. D-dimer, plasminogen activator inhibitor-1, prothrombin fragments and protein C – role in prothrombotic state of colorectal cancer.. In NEOPLASMA, vol. 58, no.3, pp. 235-238. 0028-2685.

Mytnik, M., Stasko, J. (2011). D-dimer, plasminogen activator inhibitor-1, prothrombin fragments and protein C – role in prothrombotic state of colorectal cancer.. NEOPLASMA, 58(3), 235-238. 0028-2685.