In: NEOPLASMA, vol. 53, no. 3
J. Petera - M. Doležel - Z. Jirousek - L. Tuček - J. Bedrošová - T. Frgala
Details:
Year, pages: 2006, 232 - 236
About article:
Low dose rate brachytherapy is well established treatment modality
of oral cancer. Data about high dose rate
brachytherapy (HDR BT) are still scarce with heterogenous results.
The aim of our study was to evaluate preliminary results
in a small group of oral cancer patients treated by HDR BT.
Seventeen applications were performed on 16 patients in years 2001-2004, in 15 cases for new tumor (mobile tongue
10x, floor of mouth 2x, lip 3x) and in 2 cases for local
recurrence after radiotherapy. Ten treatments (for T1-2N0 tumors
and
recurrences) were performed with brachytherapy alone (18 x 3 Gy
twice daily), seven patients (T2-3 N0-2 tumors) were
treated with a combination of external beam radiotherapy (40—68
Gy) and brachytherapy (2—6 x 3 Gy twice daily). The plastic
tubes technique was used for brachytherapy. Follow-up periods were
between 8—46 months (median 17).
Fifteen patients were disease free during follow-up period. One
patient (brachytherapy alone for T2N0M0 mobile tongue
cancer) died immediately after neck dissection for the neck
recurrence due to the heart failure. The other one died due to
distant
metastases but without local recurrence. Acute complications were
mucositis gr. II at maximum, late complications
were ulcer of soft tissues in 3 and superficial bone necrosis in 2
cases. The evaluation of the brachytherapy implants was
done according ICRU 58 recommendations.
Hyperfractionated high dose rate brachytherapy alone or as a boost
to external beam radiotherapy is feasible with promising
local control. Carefull planning of the implant and mandibular
shielding are necessary to avoid complications.
How to cite:
ISO 690:
Petera, J., Doležel, M., Jirousek, Z., Tuček, L., Bedrošová, J., Frgala, T. 2006. High dose rate brachytherapy in the treatment of oral cancer — the preliminary one institution experience. In NEOPLASMA, vol. 53, no.3, pp. 232-236. 0028-2685.
APA:
Petera, J., Doležel, M., Jirousek, Z., Tuček, L., Bedrošová, J., Frgala, T. (2006). High dose rate brachytherapy in the treatment of oral cancer — the preliminary one institution experience. NEOPLASMA, 53(3), 232-236. 0028-2685.