In: NEOPLASMA, vol. 52, no. 6
A. Sykorova - J. Horacek - P. Zak - M. Kmonicek - J. Bukac - J. Malý
Details:
Year, pages: 2005, 476 - 782
About article:
Forty-four adult autologous transplant patients with hematological
malignancies were randomized to receive either prophylactic
parenteral nutrition PN (P group), or PN given ad hoc (C group).
In each group, they were further randomized to
receive standard PN (B group), or PN with 0.5 g glutamine/kg as L-Ala-L-Gln (A group). The overall survival (OS),
disease-free survival (DFS) and event-free survival (EFS) in groups C vs.
P and A vs. B were compared during follow-up with
median 38 months. The final outcome rates in C/P/A/B groups,
respectively (OS 65/81/63/85%, EFS 45/53/33/65% and
DFS 56/50/35/77%), were not significantly different, apart from
A < B in DFS rate (p=0.03, Fisher's exact test). Also in survival
analysis (logrank test), no significant difference between groups
C and P was found but generally worse parameters
were observed for A vs. B group: for DFS (p=0.04) and EFS (p=0.01)
the difference was significant, and for OS (p=0.09) it
was borderline. In the three years' follow-up, no clinically
useful benefit of prophylactic PN in autologous transplant patients
was proven. Also, glutamine supplementation was not helpful, and
was even connected with apparently worse
long-term outcome.
How to cite:
ISO 690:
Sykorova, A., Horacek, J., Zak, P., Kmonicek, M., Bukac, J., Malý, J. 2005. A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies - three years' follow-up. In NEOPLASMA, vol. 52, no.6, pp. 476-782. 0028-2685.
APA:
Sykorova, A., Horacek, J., Zak, P., Kmonicek, M., Bukac, J., Malý, J. (2005). A randomized, double blind comparative study of prophylactic parenteral nutritional support with or without glutamine in autologous stem cell transplantation for hematological malignancies - three years' follow-up. NEOPLASMA, 52(6), 476-782. 0028-2685.