Lower Adherence to Clotting Factor Replacement Therapy in Patients with Haemophilia Associated with More Depressive Symptoms: Two Centers Cross-Sectional Study

Year, pages: 2022, 64 - 75

The aim of this study was to examine the association of depressive symptoms with medication adherence levels in a combined sample from Croatia and Slovenia. Participants in the study were adult patients with haemophilia receiving prophylaxis or on-demand treatment (N = 109). Their age was between 18 and 73 years (M = 43.86, SD = 14.89). Self-reported medication adherence (implementation phase) was measured with The Validated Haemophilia Regimen Treatment Adherence Scale, while depressive symptoms were measured with Beck Depression Inventory II. Comparison of adherence scores using t-test indicated that participants using prophylaxis were more adherent than participants using on-demand treatment on total scale and time and plan subscales. In hierarchical regression analyses depressive symptoms were a significant predictor for the total score and time subscale after controlling for sociodemographic and clinical variables. Screening for depressive symptoms and improving medication adherence of patients using on-demand treatment is recommended.

Butković, A., Bago, M., Preloznik Zupan, I., Faganel Kotnik, B., Prga Borojević, I., Bačić Vrca, V., Zupančić Šalek, S. 2022. Lower Adherence to Clotting Factor Replacement Therapy in Patients with Haemophilia Associated with More Depressive Symptoms: Two Centers Cross-Sectional Study. In Studia Psychologica, vol. 64, no.1, pp. 64-75. 0039-3320. DOI: https://doi.org/10.31577/sp.2022.01.839

Butković, A., Bago, M., Preloznik Zupan, I., Faganel Kotnik, B., Prga Borojević, I., Bačić Vrca, V., Zupančić Šalek, S. (2022). Lower Adherence to Clotting Factor Replacement Therapy in Patients with Haemophilia Associated with More Depressive Symptoms: Two Centers Cross-Sectional Study. Studia Psychologica, 64(1), 64-75. 0039-3320. DOI: https://doi.org/10.31577/sp.2022.01.839

Publisher: Institute of Experimental Psychology, Centre of Social and Psychological Sciences, Slovak Academy of Sciences

https://creativecommons.org/licenses/by/4.0/