In: ENDOCRINE REGULATIONS, vol. 52, no. 3
Details:
Year, pages: 2018, 146 - 151
Language: eng
Keywords:
resistance training, leucine, diabetes mellitus, rats, lipid profile
Article type: Research Article
Document type: Research Article
About article:
Objectives. Diabetes mellitus is associated with dyslipidemia, which contributes to a higher risk
of thrombosis, atherosclerosis and cardiovascular disease. This study evaluated the effects of leucine and resistance training on the serum lipid profile in rats with streptozotocin-induced diabetes for 8 weeks.
Methods. Wistar rats with neonatal streptozotocin-induced diabetes were treated with leucine supplementation (5%) and/or resistance training (3 days per week) for 8 weeks, and divided in DL (diabetic and leucine), DT (diabetic and resistance training group) and DLT (diabetic, leucine and resistance training) groups. Others 2 groups of animals received isonitrogen AIN-93M diet that was defined as a control diet: group D (diabetic untreated) and group C (non-diabetic).
Results. The decrease in serum total cholesterol and increase in high-density lipoprotein cholesterol (HDL-C) was observed in the resistance training-induced diabetic rats when compared with diabetic rats. There was no change in serum lipid profile in leucine-supplemented diabetic rats and no synergistic effect of leucine and resistance training. The fasting glucose levels were reduced in all animals treated compared to D group.
Conclusion. The diabetic trained rats demonstrate a protective effect of resistance training on the serum lipid profile.
About edition:
Publisher: Sciendo
Published: 9. 8. 2018