Implantation and pregnancy outcome of Sprague-Dawley rats exposed to pirimiphos-methyl

Year, pages: 2019, 139 - 145

Objective. This study was designed to investigate the effect of sublethal doses (10, 60, and 120 mg/kg of pirimiphos-methyl on implantation and pregnancy in female Sprague-Dawley rats. Pirimiphos-methyl is a pesticide widely used worldwide, especially in Africa to protect food against pests and has gained widespread acceptance. Methods. Pregnant Sprague-Dawley rats used for this study had access to food and water ad libitum and were divided into a control group and three experimental groups based on dose of chemical given. The pregnant rats were given pirimiphos-methyl orally on days 1–5, 1–7, 7–18th day of gestation and from day 1 to term. Implantation studies were carried out on days 6 and 8 of pregnancy, while the fetal parameters were ascertained on day 19 of pregnancy and at term. Serum levels of progesterone and estradiol were measured on days 6, 8 and 19 of pregnancy. Results. Sublethal administration of pirimiphos-methyl showed decreased number of implantation sites on days 6 and 8, fetal weight, crown-to-rump length, length of umbilical cord and placenta weight (day 19), birth weight, litter size and total number (at term) in rats administered with pirimiphos-methyl when compared with control. Conclusion. Administration of pirimiphos-methyl resulted in a reduced implantation rate due to decreased uterine receptivity caused by an imbalance in the level of estradiol and progesterone and impaired reproductive outcome during pregnancy.

Oyesola, T., Iranloye, B., Adegoke, O. 2019. Implantation and pregnancy outcome of Sprague-Dawley rats exposed to pirimiphos-methyl. In ENDOCRINE REGULATIONS, vol. 53, no.3, pp. 139-145. 1210-0668. DOI: https://doi.org/10.2478/enr-2019-0014

Oyesola, T., Iranloye, B., Adegoke, O. (2019). Implantation and pregnancy outcome of Sprague-Dawley rats exposed to pirimiphos-methyl. ENDOCRINE REGULATIONS, 53(3), 139-145. 1210-0668. DOI: https://doi.org/10.2478/enr-2019-0014

Publisher: Sciendo