In: NEOPLASMA, vol. 52, no. 5
C. Junghanss - M. Waak - A. Knopp - H.d. Kleine - G. Kundt - M. Leithäuser - I. Hilgendorf - D. Wolff - J. Casper - M. Freund
Details:
Year, pages: 2005, 402 - 410
About article:
Identification of additional prognostic factors besides karyotype
is important for the improvement of the risk adapted
treatment strategies in acute myeloid leukemia (AML). The aim of
this study was to investigate whether other factors besides
karyotype could be used as a prognostic tool in newly diagnosed
AML.
Biological and disease related established and potential
prognostic factors were retrospectively analysed in 124 consecutive
AML patients treated between 1993 and 2002 at the University
hospital Rostock (Germany). One hundred patients received
a potential curative intensive chemotherapy (81%), of whom 28
received an allogeneic HSCT at some point of their
treatment course, 17 patients (14%) received palliative therapies
and 7 patients (5%) received supportive care only. In patients
that received potential curative therapies LDH ≥2000 U/l, WBC >50
GPT/l, CD34 surface expression on the AML
blasts, secondary AML, unfavorable karyotype and no allogeneic
HSCT at some point of treatment course were associated
with unfavorable prognosis. However, in the multivariate risk
factor analyses only unfavorable karyotype (p=0.012), CD34
positivity of AML blasts (p=0.046), no allogeneic HSCT (p=0.008)
and first diagnosis after 1997 (p=0.025) were independent
unfavourable prognostic factors.
In conclusion, karyotype and CD34 expression are independent
prognostic markers in newly diagnosed AML. Furthermore,
receiving an allogeneic HSCT at some point of the treatment course
seems to be of benefit for AML patients.
How to cite:
ISO 690:
Junghanss, C., Waak, M., Knopp, A., Kleine, H., Kundt, G., Leithäuser, M., Hilgendorf, I., Wolff, D., Casper, J., Freund, M. 2005. Multivariate analyses of prognostic factors in acute myeloid
leukemia:
relevance of cytogenetic abnormalities and CD34 expression. In NEOPLASMA, vol. 52, no.5, pp. 402-410. 0028-2685.
APA:
Junghanss, C., Waak, M., Knopp, A., Kleine, H., Kundt, G., Leithäuser, M., Hilgendorf, I., Wolff, D., Casper, J., Freund, M. (2005). Multivariate analyses of prognostic factors in acute myeloid
leukemia:
relevance of cytogenetic abnormalities and CD34 expression. NEOPLASMA, 52(5), 402-410. 0028-2685.