Information Page of SAS Organisation

Institute of Parasitology

International projects

COMBAR - Combatting anthelmintic resistance in ruminants
Boj proti rezistencii na antihelmintiká u prežúvavcov
Program: COST
Project leader: doc. MVDr. Várady Marián DrSc.
Project web page:http://www.cost.eu/COST_Actions/ca/CA16230
Duration: 1.9.2017 - 1.9.2021

EURO-FBP - European Network for Foodborne Parasites (EURO-FBP)
Európska sieť pre potravinami prenášané parazity.
Program: COST
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:The main objective of EURO-FBP is to decrease the impact on human health from foodborne parasites (FBP), through establishing a risk-based control programme for FBP containing robust and appropriate protective strategies. EURO-FBP will use an interdisciplinary, One Health perspective to assimilate information, coordinate research and harmonize diagnostics, surveillance, analytical methods, potential interventions and mapping of global trends regarding FBP. The Action will determine those FBP of greatest regional importance, pinpoint knowledge gaps, and focus resources strategically for control of FBP. FBP include protozoa, nematodes, cestodes and trematodes. Although a significant public health issue, FBP have been neglected compared with other foodborne pathogens such as viruses or bacteria. Furthermore, globalisation and changes in climate, agricultural practices, and human behaviour and lifestyles all contribute to emergence of FBP in new settings, with new hosts and transmission routes. Previously associated with specific regions, FBP are now spreading. FBP research is fragmented and groups often focus on a single genera or group of parasites. Hence COST is ideal for EURO-FBP, enabling collaboration among scientists that rarely interact. The agenda will focus on how to address FBP, optimising efforts and resources in order to control FBP in Europe - and globally.
Duration: 30.3.2015 - 29.3.2019

Immunological and molecular diagnostics of parasitic diseases of rodents living in different ecosystems of the national parks in Poland and Slovakia
Imunologická a molekulárna diagnostika pôvodcov parazitárnych chorôb hlodavcov žijúcich v rôznych ekosystémoch národných parkov Poľska a Slovenska
Program: Medziakademická dohoda (MAD)
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:The main aim of the project is to study occurrence and prevalence of such important parasitic diseases as: echinococcosis (Echinococcus multilocularis, Echinococcus granulosus), trichinellosis, toxoplasmosis, neosporosis, babesiosis, anaplasmosis, borreliosis and ehrlichiosis in the Białowieża Primeval Forest (Poland) and the Tatra National Park (Slovakia) in the rodents’ hosts. Proven immunological and molecular methods can provide reliable results.
Duration: 1.1.2016 - 31.12.2018

In vivo activity of silymarin flavonolignans on model infection induced with cestode Mesocestoides vogae in mice.
In vivo aktivita silymarínových flavonolignanov na modelovú infekciu vyvolanú pásomnicou Mesocestoides vogae u myší.
Program: Bilaterálne - iné
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:Medically important species of cestodes Echinococcus multilocularis, E. granulosus, Taenia solium cause serious diseases in various hosts, while humans can be infected accidentally. It is estimated that millions of people suffer from these disease mostly in resource-poor communities worldwide with limited therapeutic possibilities. Infection with cestode Mesocestoides vogae shares many pathological and molecular similarities with these diseases and was recommended by WHO (1996) as a suitable model in pharmacological, molecular and immunological studies. Silymarin represents mixture of flavonolignans, namely silybin, isosilibyn A, silydianin and silychristin. The pleiotropic mode of action of silymarin (antioxidant, antifibrotic, immunomodulatory, anti-cancer) has been reported but cestocidal potential of silymarin flavonolignans has not been studied in vivo. Recently we have demonstrated profound larvicidal activity due to interference with metabolic and enzymatic pathways in M. vogae larvae. The objective of present project is to reveal complex effects of individual flavonolignans during M. vogae infection in BALB/c mice.
Duration: 1.1.2018 - 31.12.2020

Tick-borne diseases zoonotic foci in urban habitats of Poland and Slovakia
Kliešťami udržiavané ohniská ochorení zoonotického charakteru v mestách Poľska a Slovenska (2016 – 2018).
Program: Medziakademická dohoda (MAD)
Project leader: doc. RNDr. Stanko Michal DrSc.
Annotation:Ticks are worldwide haematophagous parasites on humans and domestic animals.T ick species found in towns in central Europe are Argas reflexus (Argasidae), Ixodes ricinus, I. hexagonus and Dermacentor reticulatus (Ixodidae). These ticks are vectors of human and animal zoonotic diseases, the most important are rickettsioses, Lyme-disease, HGE, babesiosis. The zoonotic foci of tick-borne diseaseas are situated mainly in natural environment, however, many infection cases are acquired in urban aglomeration. The goal of the project is the description of the zoonotic foci in big agglomerations in Poland and Slovakia, outlines the biology and the medical significance of tick species which colonize urban and suburban environments, their associations with small mammals, and describing the ecological circumstances of their occurrence. The second aim of this study is to estimate the risk of infection of mammals and hard ticks by the agents of tick-borne diseases (Lyme disease, anaplasmosis, babesiosis, rickettsioses) and risk of their transmission to human.
Duration: 1.1.2016 - 31.12.2018

RYBZOO - Emerging and Re-emerging Zoonotic Parasitosis Caused by Fish-Borne Parasites: Health Risks Associated with Consumption of Fish
Novo sa objavujúce rybami prenášané zoonózy: zdravotné riziká spojené s konzumáciou rýb
Program: JRP
Project leader: RNDr. Oros Mikuláš PhD.
Annotation:Consume raw and improperly cooked fishes may transmit fish-borne zoonotic diseases, which are currently (re-)emerging also due to population movement and climate changes. The aims of proposed collaborative project are focused on to the assessment of present occurrence, host associations, and current distribution and transmission routes of potential causative agents of fish-borne diseases in Taiwan as an important endemic area. Trematodes (Clonorchis, Metagonimus, Haplorchis) responsible for human liver and intestinal infection, respectively, broad fish tapeworm (Diphyllobothrium) causing diphyllobothriosis and the anisakid nematodes (e.g. Anisakis simplex) causing human anisakiosis, will serve as model parasite groups. The novelty of the project lies in its interdisciplinary character, i.e., application of different methodological approaches, e.g., morphology, ultrastructure, phylogeography, phylogenetics and molecular karyology. The project will be based on international cooperation with a key role of Slovak parasitologists experienced in multidisciplinary studies on the helminth parasites including causative agents of zoonotic diseases and fish surveys to detect their infective stages.
Project web page:http://pau.saske.sk/project-sav-most/
Duration: 1.3.2017 - 31.12.2019

Parasites in domestic and wild carnivores from Slovakia and Bulgaria in the era of global changes
Parazity domácich a voľne žijúcich mäsožravcov na Slovensku a v Bulharsku v období globálnych zmien
Program: Medziakademická dohoda (MAD)
Project leader: MVDr. Hurníková Zuzana PhD.
Annotation:Free living carnivores are involved in maintenance and spread of several viral, bacterial and parasitic zoonotic diseases; potentially transmissible to domestic, farm and game animals, and also to humans. The project is focused at comparison of the parasite fauna composition of domestic and free living carnivores in both Bulgaria and Slovakia including parasitic agents transmissible to man. The occurrence of parasites in ecologically different areas will be collated and the host-parasite-landscape interactions studied. Molecular characteristic of parasite strains as well as the homology of isolates obtained in selected areas will provide the basis for evaluation of possible spread of parasites from south (Bulgaria) northward (Slovakia. The risk factors that advance the parasite circulation and risk areas of increased appearance of reservoirs, vectors and potential hosts with respect to spread of parasitic infections will be identified.
Duration: 1.1.2018 - 31.12.2020

FishPara - Joint investigation of fish parasite diversity in the Yangtze River basin: uncovering the hidden species diversity and exotic invasions
Spoločný výskum parazitov rýb v povodí rieky Yangtze: odhalenie skrytej druhovej diverzity a exotické invázie
Program: Bilaterálne - iné
Project leader: RNDr. Oros Mikuláš PhD.
Annotation:China is zoogeographically remarkable area where the Palaearctic and Oriental faunas come into contact. There are several faunistic reports on tapeworms from various fish hosts, but complex taxonomical and genetic research on these parasites is relatively limited. Validity of numerous Chinese taxa is still questionable. The proposed collaborative project aims at obtaining new data on the fish parasites from the Yangtze River basin, with focus on poorly- studied regions and taxonomically problematic taxa. Taxonomical revisions, genetic structure and detailed karyotype research, including descriptions of new taxa and unknown karyotypes, will be performed. The novelty of the project is application of a wide array of approaches (alpha-taxonomy and morphology, modern tools of genetics and karyology) which will enable us to obtain an original and extensive data set applicable to further faunistic, taxonomic and phylogenetic studies. The project also has important outcomes for theoretical parasitology and veterinary practice, because detailed information about potential pathogens of cultured fish and invasive species will also be provided. The tapeworms of the order Caryophyllidea (Cestoda), representatives of phylogenetically old, so-called basal tapeworms, are typical component of the parasite fauna of China, that have been well studied in our laboratory before have been selected as principal model parasite groups.
Duration: 1.1.2018 - 31.12.2019

Eggs ultrastructure of the basal tapeworm groups (Caryophyllidea, Diphyllobothriidea)
Ultraštruktúra vajíčok bazálnych skupín pásomníc (Caryophyllidea, Diphyllobothriidea)
Program: Bilaterálne - iné
Project leader: RNDr. Bruňanská Magdaléna DrSc.
Duration: 1.1.2018 - 31.12.2020


National projects

Transmission and risk analyses of epidemiologically important helminths using genetic and biochemical markers
Analýzy prenosu a rizika epidemiologicky významných helmintov genetickými a biochemickými markermi
Program: VEGA
Project leader: RNDr. Šnábel Viliam CSc.
Annotation:In closely related nematode species Ascaris suum (pig parasite) and Ascaris lumbricoides (human parasite), host transmission patterns, frequency of cross infections and abundance of hybrid forms will be determined. Evaluations of distributions of major clusters of mitochondrial DNA according to hosts and geographical regions (central Europe, East Asia, South America) will contribute to a deeper knowledge about genetic structure and evolution in Ascaris genus. Degrees of inbreeding that are critical for predicting the dynamics of drug-resistance evolution will be estimated in population offspring. In Echinococcus granulosus sensu lato tapeworms from central and eastern Europe, genotype spectrum circulated in the region will be more accurately delineated. Level of occurrence of highly infective E. granulosus sensu stricto species will be surveyed and causes of its recent spread from Mediterranean region will be thoroughly discussed.
Duration: 1.1.2017 - 31.12.2020

Cytomorphological aspects of reproduction and phylogeny in the parasitic Platyhelminthes
Cytomorfologické aspekty reprodukcie a fylogenéza parazitických plathelmintov
Program: VEGA
Project leader: RNDr. Bruňanská Magdaléna DrSc.
Annotation:The purpose of the present project is to obtain new information about gametogenesis and gametes ultrastructure in the Monopisthocotylea and Eucestoda, parasitic platyhelminthes with parallel evolution. The members of endoparasitic monocotylid monogeneans and evolutionary pivotal groups of the tapeworms (Caryophyllidea, Spathebothriidea, Nippotaeniidea), fish parasites, will be in focus. The proposal of a new classification of spermatozoa and new information about feasibility of the use of eggs/oncospheres for species diagnosis and phylogeny in the Eucestoda will be provided. Ultrastructural methods include the most advanced techniques, e.g. electron tomography. Expected results may contribute to better understanding of reproduction and evolution of the parasitic platyhelminthes, their life strategies, morphological adaptations to parasitism, with possible consequences on effective control of parasitic diseases. The international cooperation and students participation are planned within the proposed project.
Duration: 1.1.2016 - 31.12.2019

EMFIBOR - Emerging fish-born zoonoses in Europe: molecular diagnostics, origin and distribution of Diphyllobothrium
Difylobotrióza - novo sa objavujúca, rybami prenášaná zoonóza v Európe: molekulárna diagnostika, pôvod a rozšírenie parazita
Program: APVV
Project leader: RNDr. Hromadová Ivica CSc.
Annotation:The fish-borne diseases have currently been expanding into new regions, including well developed countries of the world, due to growing international markets, demographic and climate changes. One of the most important fish-borne parasitic zoonosis is diphyllobothriosis (Cestoda: Diphyllobothriidea) with about 20 million people being infected worldwide. Although these tapeworms have been recognized for a long time, many aspects of their taxonomy, biology, origin, distribution and epidemiology remain poorly known. The current project has an ambition to determine new multidisciplinary species-specific characteristics of Diphyllobothrium spp. with a broader aim to improve diagnostics of larval stages from fish, preferably those infecting humans and potentially colonizing new geographical areas. One of the principal aims of the project is to understand an origin, distribution and transmission routes of Diphyllobothrium spp. and to resolve whether they are native in Europe or represent a result of trans-continental introductions. Original data on prevalence of larval diphyllobothriosis in feral fish in natural conditions in Slovakia will be determined, as well.
Duration: 1.7.2016 - 30.6.2020

Small mammals as a potential source of zoonotic bacteria and resistence to antibiotic
Drobné cicavce ako potenciálny zdroj zoonotických bakterií a rezistencie na antibiotiká
Program: APVV
Project leader: doc. RNDr. Stanko Michal DrSc.
Annotation:The project aims to significantly improve understanding of the various components of the natural foci, focusing on emerging diseases. The emphasis is on the role of small mammals as hosts of several groups of ectoparasites (ticks, fleas, mites), vectors of natural foci diseases agents, and the role of rodents as reservoirs of bacterial zoonotic diseases agents (Borrelia burgdorferi s.l., Anaplasma phagocytophilum, Bartonella spp., Rickettsia spp .). Considering the conditions of Central Europe, identification of potential pathogens of intestinal and skin microbiota in small mammals will be performed using Maldi-Tof method and “next generation” sequencing. The project focuses on the structure of natural foci components, infestation of reservoir animals and vectors by the selected zoonotic agents in three habitat types with varying degrees of anthropogenic disturbance (urban, suburban, national park). Detection of pathogens based on molecular - genetic methods and a study of reservoir - vector - pathogen relationships will be performed using scientific personnel and material and technical resources of three top research workplaces of the SAS.
Duration: 1.7.2015 - 30.6.2019

Eco-epidemiology of Borrelia miyamotoi in Slovakia
Eko-epidemiológia Borrelia miyamotoi na Slovensku
Program: VEGA
Project leader: RNDr. Majláthová Viktória PhD.
Duration: 1.1.2018 - 31.12.2021

FUPKOPROSP - Functional food based on goats milk and its benefit on health
Funkčné potraviny na báze kozieho mlieka a ich prospešnosť pre zdravie
Program: APVV
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:Functional food, can be characterized as common and/or traditional food enriched with special component; component will allott to that that food term functional meaning immunity stimulation, tracy elements addition to the body following the principal aim to have beneficial effect on health. Relating to dairy industry or agriculture, nowadays is prefering goats milk and/or products made up from it. In the framework of functional food is very popular and acceptable involving of probiotic bacteria; after their colonization in host organism, they can form ideal environment which with their metabolites or with their involving in the receptors influencing immune system can beneficially influence host organism.These bacteria can reach host organism/consumer by two ways: per os or via food. The project is focused on isolation, identification, general and technological characterization of autochtonnous lactic acid bacteria from goats milk and cheese of different Slovak producers; suitable, selected strain will be applied into product made up of goats milk in semi-processing (laboratory) conditions as well as in dairy-farming – customer of project application output condition; then the application form and effect of that one functional food will be tested using volonters (via consumption of cheese or the other products made up of goats milk). Application output will be the authochtonnous culture which could be used for technological processing of goats milk and/or products made up of it; these together with their final benefit on cunsumer health could allott that product to functional food.
Duration: 1.8.2018 - 31.7.2022

Genetic analysis of selected emerging and re-emerging pathogens with zoonotic potential in animals and humans.
Genetická analýza vybraných a novo sa objavujúcich patogénov so zoonotickým potenciálom u zvierat a ľudí.
Program: VEGA
Project leader: doc. RNDr. Stanko Michal DrSc.
Annotation:Emerging, resp. re-emerging infectious diseases are diseases caused by completely new or previously undetected pathogenic microorganisms, but also diseases which may be caused by a known pathogen which has begun to spread to new geographical areas or to a new host group. The origin and nature of these diseases determine not only climatic, environmental and social factors, but also economic, and therefore it is very difficult to predict when and where the next pathogen will be occurs. Approximately 75% of these diseases are zoonoses. The presented project deals with viral hepatitis E, microsporidiosis, cryptosporidiosis, chlamydiosis and anaplasmosis, whose common denominator is their zoonotic character and their inclusion in a group of emerging or reemerging diseases. Project detects their prevalence in a group of animals and humans, and by genotyping the species monitors their mutual transmission. The result is to determine the current epidemiological and epidemiological situation in their occurrence.
Duration: 1.1.2018 - 31.12.2021

GEDIMEP - Genetic diversity of selected medically important emerging a re-emerging pathogens with zoonotic potential
Genetická diverzita vybraných medicínsky dôležitých, nových a novo sa objavujúcich patogénov so zoonóznym potenciálom
Program: APVV
Project leader: doc. RNDr. Stanko Michal DrSc.
Duration: 1.7.2016 - 30.6.2019

Modulatory effects of probiotic bacteria on the host immunity to a parasitic zoonosis caused by Trichinella spiralis
Modulačné účinky probiotických baktérií na imunitu hostiteľa pri parazitozoonóze vyvolanej Trichinella spiralis
Program: VEGA
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:A potential protective effect of probiotic and bacteriocin-producing bacterial strains on Trichinella spiralis infection, a parasitic zoonosis, will be investigated in the framework of a new therapeutic strategy to use probiotics to control parasitic zoonosis. Gut microbiota during parasitic infection and its interaction with host immunity, stimulation of cells (lymphocytes, macrophages) and cytokine production, which are important in induction and regulation of the immune response, will be studied. The immunogenic activity of bacterial strains will be observed at levels of local (gut) and systemic, innate and acquired, nonspecific and specific immunity. A link between administration of probiotic bacteria, immune effectors induction, and parasite elimination will be established. The project contribution will be a strain-specific characterization of immunogenic properties of tested bacterial strains as promising candidates for prophylactic or therapeutic immunomodulation of the host with trichinellosis.
Duration: 1.1.2015 - 31.12.2018

Newly emerging parasitic and vector-borne diseases in dogs, their epidemiology and diagnostic
Novo sa objavujúce závažné parazitárne a vektormi prenášané ochorenia psov, ich epidemiológia a diagnostika
Program: VEGA
Project leader: MVDr. Miterpáková Martina PhD.
Annotation:The proposed project evolves the topic of parasitic and other vector-borne infections, many of which expanded to Slovakia in recent years (dirofilariosis, angiostrongylosis, babesiosis, anaplasmosis) or their incidence is increasing due to imported cases (leishmaniasis). The main focus groups of epidemiological studies are dogs as the most numerous group of pets. The practical importance of the project is emphasized by the lack of knowledge on the prevalence and pathogenicity of agents, the incidence of various co-infections that may not only contribute to the deterioration of the patient’s health status, but also negatively affect the diagnosis and course of treatment. The outcomes of the project will provide foreground comprehensive data on distribution of newly emerging parasitic and vector-borne diseases in the territory of Slovakia for optimization of effective methods of routine diagnostics.
Duration: 1.1.2016 - 31.12.2019

GoShEncephal - Sheep, Goats and Tick-borne Encephalitis virus
O ovciach, kozách a víruse kliešťovej encefalitídy
Program: APVV
Project leader: RNDr. Víchová Bronislava PhD.
Annotation:The aim of the project is a comparative analysis involving sheep and goats foodborne infections. With regard to exact criteria, a representative number of farms from whole Slovakia will be selected. We will screen the milk and milk products of sheep and goats, ticks collected from direct observation of the animals as well as those collected by flagging the vegetation around the farms. Samples will be examined by highly sensitive molecular biological methods for the presence of virus . From animal blood we will evaluate the serological status of all investigated animals. Based on the evaluation of the results we will be able to see how the sheep and goats are engaged in the food-borne infections in Slovakia. In the case of virus positive samples, we will obtain very valuable information about the genetic diversity of the TBEV in our country. An important outcome of the project will be the specific methodological recommendations for farmers in terms of preventing foodborne disease.
Duration: 1.7.2017 - 30.6.2021

PARIMUN - Clarification of the immunomodulatory effects of DLE (dialyzable leukocyte extract) in the therapy of mice with parasitic infections of immunosuppressive character.
Objasnenie imunomodulačných účinkov DLE (dialyzovateľný leukocytárny extrakt) pri liečbe myší s parazitárnymi infekciami imunosupresívneho charakteru
Program: APVV
Project leader: RNDr. Hrčková Gabriela DrSc.
Duration: 1.8.2018 - 30.6.2022

Fish tapeworms (Cestoda) in North America: new knowledge on evolutionary and medically important parasites
Pásomnice (Cestoda) rýb v Severnej Amerike: získanie nových poznatkov o evolučne a medicínsky významných parazitoch
Program: VEGA
Project leader: RNDr. Oros Mikuláš PhD.
Annotation:The project deals with the taxonomic research of so far little known diversity of tapeworms of the order Caryophyllidea, parasites of freshwater fishes. Within this group, an occurrence of hidden ‘cryptic species’ and ‘criptic species complex’ is frequently recorded. The research will be primarily focused on aforementioned species, taxonomically doubtful species ‘species inquirenda‘, insufficiently described species requiring re-description as well as taxa important from phylogenetic point of view. A special attention will be paid to alien species, naturally or intentionally introduced to Slovakia, posing a potential threat to ichthyofauna and biodiversity protection. New morphological and genetic data will be obtained along with new knowledge on biology and adaptations of these tapeworms. The key outputs arising from this project will be descriptions of several new caryophyllidean tapeworms and revision of several genera from the different geographical regions of the world.
Duration: 1.1.2016 - 31.12.2019

Population-genetic characterization of invasive parasitic species (Platyhelminthes); determination of their origin and migratory routes
Populačno-genetická charakterizácia inváznych druhov parazitov (Platyhelminthes); determinácia ich pôvodu a ciest šírenia
Program: VEGA
Project leader: MVDr. Bazsalovicsová Eva PhD.
Duration: 1.1.2017 - 31.12.2020

Soil nematodes and microorganisms: indicators of impact of non-native plant species invasion to the ecosystem
Pôdne nematódy a mikroorganizmy: indikátory dopadu invázie nepôvodných druhov rastlín na ekosystém.
Program: VEGA
Project leader: Ing. Renčo Marek PhD.
Annotation:Spread of invasive alien plant species are becoming an increasing threat for plant species diversity of the resident communities, which directly affects the soil organisms. The main objective of the project is to characterize the structure of communities of soil nematodes, functional diversity of microorganisms and activity of microbial community in natural ecosystems with the native plant communities and ecosystems affected by the invasion of non-native plant species. To analyze the impact of the invasion of non-native plant species on community structure, changes in nematode species diversity, depending on the species of invasive plants. Assess the soil condition of the native and invaded ecosystems by the using of soil nematodes and microorganisms as indicators. Analyze the relationships between plants, soil microorganisms and nematodes.
Duration: 1.1.2016 - 31.12.2019

Natural foci in urban environment - the case of the Košice agglomeration: structure and dynamics in space and in time
Prírodné ohniská v mestách na príklade košickej aglomerácie: štruktúra a dynamika v priestore a čase.
Program: VEGA
Project leader: doc. RNDr. Stanko Michal DrSc.
Annotation:The project aims to confirm active natural foci in the urban environment. Using the model of the Košice agglomeration, three major components of natural foci will be studied: 1. small mammals (reservoir animals) 2. vectors of natural foci disease agents (several groups of ectoparasitic arthropods), 3. significant bacterial and protozoan pathogens (Anaplasma, Bartonella, Rickettsia, Babesia and other) in the reservoir animals and vectors. The prevalence of ticks on vegetation will be estimated along with seasonal dynamics of their abundance in the model areas within studied territory. The impact of micro-climatic factors on the distribution and changes in the population of ticks during the year will be analysed in order to design relevant risk maps for the studied areas.
Duration: 1.1.2015 - 31.12.2018

FIBROTICK - Antitick protection using of modified polypropylen fibres with an acaricidal effect
Protikliešťová ochrana pomocou modifikovaných polypropylénových vlákien s akaricídnym účinkom
Program: APVV
Project leader: doc. MVDr. Peťko Branislav DrSc.
Annotation:The project is interdisciplinary, combining experience of experts in parasitology and chemical technology, based on the informal co-operation. It resolves an innovative technology of manufacturing polypropylene modificated fiber with persistent anti-tick modification PROLENTICK FT with firmly incorporated active substance in matrix and on the surface with different concentration and also with various technology of fixation of active substance in the fiber and to provide to textile industry a new product – modified fiber with high quality in various silkiness, resistant to common mechanical (e.g. abrasion), physical (e.g. washing, moisture, rain, sun emission) and chemical (e.g. sweat) efforts. This textile materials made from functional fibers will be tested for repellent effect for the most significant species of ticks in Slovakia and central Europe – Ixodes ricinus ticks and Dermacentor reticulatus. Functional textiles made from these fibers will have very wide spectrum of utilization in everyday living for people visiting areas with tick distribution regularly or sporadically, also for production of different complements and harnesses for livestock and farm animals with antitick effect. Original progressive types of polypropylene fibres will be on the offer to produce qualitatively innovative textile materials with a higher added value.
Duration: 1.7.2016 - 31.12.2018

FORSOIL - Vegetation, soil microorganisms and carbon sequestrations in forest soils
Rastliny, pôdne mikroorganizmy a sekvestrácia uhlíka v lesnych pôdach
Program: APVV
Project leader: Ing. Renčo Marek PhD.
Annotation:The main project objective is to analyse and clarify the interactions between plant communities, belowground organisms and soil properties (with emphasis on the ability of the soil to sequestrate carbon) in natural forest stands and stands influenced by human activities (different management of forest stands, land use changes,invasive plant species).The proposed project deals with the fundamental questions in soil and plant ecology and productivity with the emphasis on soil microorganisms and plant diversity and carbon sequestration.From the scientific point of view the project will rely especially on a complex evaluation of elationships and functions in the system plant-microbiota-soil and factors influencing them. At the same time, the study of soil microbial community on functional and genomic level using DNA analysis will provide completely new information in this field of research. Understanding the plant and microbial community interactions and they role in the C sequestration may lead to the development of land-management model and practices, which can be followed in the increase of C sequestration potential of soils.
Duration: 1.7.2016 - 30.6.2020

Relictual forms of arthropods (Arthropoda) in the Western Carpathians – morphology, ecology and phylogeny
Reliktné formy článkonožcov (Arthropoda) v Západných Karpatoch – morfológia, ekológia a fylogenéza
Program: VEGA
Project leader: RNDr. Miklisová Dana PhD.
Annotation:During the last decades the wide spectrum of unique relictual forms of arthropods in territory of the Western Carpathians has been revealed. Most of them have remained taxonomically unresolved and their ecology is poorly undestood, obligate cave forms including. The aim of the project is to study detailed morphology of these relicts assigned to Palpigradi, Acari, Amphipoda, Diplopoda, Collembola and Lepidoptera. Futhermore, the project aims to bring the data on their ecology by a detailed populational study. Phylogenetic approach based on analysis of two molecular markers will be applied for the selected taxa, specifically the family Attemsiidae (Diplopoda), the genera Pseudosinella and Pygmarrhopalites (Collembola), and relictual populations of the selected alpine and steppe species of Lepidoptera. The project is based on the complex methodology, i.e. combination of the morphology and ecology study of relictual arthropod populations with molecular analyses in reconstruction of the phylogenetic lineages.
Duration: 1.1.2018 - 31.12.2021

Parasite resistance to anthelmintics - Challenges, perspectives and solutions
Rezistencia parazitov na antihelmintiká - výzvy, perspektívy a riešenia
Program: APVV
Project leader: doc. MVDr. Várady Marián DrSc.
Duration: 1.7.2015 - 30.6.2019

ParaDise - Standardisation of new approaches in the diagnosis of important helminthic diseases of humans and their application into the practice in the light of actual epidemiological and social conditions of Slovakia.
Štandardizácia nových prístupov v diagnostike závažných helmintóz ľudí a ich aplikácia do praxe v aktuálnych epidemiologických a sociologických podmienkach Slovenska.
Program: APVV
Project leader: MVDr. Antolová Daniela PhD.
Annotation:Global changes of epidemiological, socio-economic and ecological character have contributed significantly to the spread of infectious and parasitic diseases in the past decades. In Slovakia, due to impact of these changes, new parasitic zoonoses emerged – echinococcosis and dirofilariosis, and also other agents of severe helminth diseases still pose the risk of human infection. It potentiates the need of correct diagnosis based on up-to-date scientific knowledge. The project aims to create at IP SAS groundwork for creation of highly specialised centre that will provide to physicians, hospitals and diagnostic laboratories facilities beyond conventional laboratory diagnostics, including superdiagnosis of parasitic diseases (validation and confirmation of diagnosis in doubtful cases), and identification of diseases agent on species level. This will create the opportunities for the self-financing of research and function of IP SAS, which, in the light of transformation of Slovak Academy of Sciences to public-research institutions, becomes upcoming and high-priority task.
Duration: 1.7.2016 - 30.6.2020

Wild ruminants as potential risk factor for transmission of anthelmintic resistant parasites between small ruminant farms.
Voľne žijúce prežúvavce ako potenciálny rizikový faktor prenosu rezistentných parazitov medzi chovmi malých prežúvavcov
Program: VEGA
Project leader: MVDr. Königová Alžbeta PhD.
Annotation:Anthelmintic resistance in parasites of small ruminants has been known for more than four decades. In response to the discussed issues of resistance in gastrointestinal parasites of ruminants, our aim is to map out yet unexplained aspects of the possible transmission of resistant parasites from small to wild ruminants using the latest knowledge about the transmission and detection of resistant strains. During the grazing seasons between 2016-2018, different species of animals will be experimentally infected with Haemonchus contortus. The project outcome will be a set of general recommendations for the management of sheep and goats applicable in the control of gastrointestinal parasites and eliminating the prevalence of resistant strains.
Duration: 1.1.2016 - 31.12.2018

The impact of anthropogenic contanimation on the occurrence of the microbial and parasitic organisms in environment within urban and rural ecosystems
Vplyv antropogénnej záťaže na výskyt mikrobiálnych a parazitických organizmov v životnom prostredí v urbánnych a rurálnych ekosystémoch
Program: VEGA
Project leader: doc. RNDr. Papajová Ingrid PhD.
Duration: 1.1.2017 - 31.12.2020

Effect of model tapeworm Mesocestoides vogae infection on the expression and functions of selected regulatory molecules in myeloid cells in mice.
Vplyv infekcie modelovou pásomnicou Mesocestoides vogae na expresiu a funkcie vybraných regulačných molekúl myeloidných buniek u myší.
Program: VEGA
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:Proliferating larval stages of medically important flatworms such as Echinococcus spp. and Taenia spp. dwell in the tissues of humans and animals for long period of time causing chronic infections, lethal in untreated cases. Cells arising in bone marrow during myelopoesis are primary targets of immunomodulations by parasites and their secretion, resulting in dominant Th2 type immunity and induction of immature cells with suppressive functions. Fast developing larval cestodose induced by Mesocestoides vogae is a suitable model infection as larvae secrete high amount of active molecules in vitro. Aim of project is to clarify activity of M. vogae larvae and their products on myeloid cells during infection in mice and on isolated cells. Their impact on expression of selected receptors and other molecules will be determined in correlation with changes in cell functions and phenotypes. Understanding the mechanisms of expansion of suppressive myeloid cells may lead to development of more effective therapy.
Duration: 1.1.2017 - 31.12.2020

The structure and dynamics of montane natural foci of tick-borne diseases
Výskum štruktúry a dynamiky prírodných ohnísk kliešťami prenášaných nákaz horského typu.
Program: VEGA
Project leader: RNDr. Víchová Bronislava PhD.
Annotation:The proposed project is aimed at the comprehensive research of the structure of tick-borne diseases natural foci in chosen mountain areas of Europe under the impact of global climate and socio-economic changes. The project will concentrate the research of ticks' ecology, epidemiology, and epizootiology of tick-borne diseases, with emphasis on serious viral (tick-borne encephalitis), bacterial and protozoan infections of human and animals. It will be a direct continuation of the studies of genetic variability of tick-borne pathogens in urban and recreational areas, which were realized within several VEGA and APVV projects, EU structural funds and dissertation theses solved at the Department of Vector-Borne Diseases (Institute of Parasitology SAS). For detection of tick-borne pathogens, methods of molecular biology and genetic will be used. The project aims to integrate the scientific research, educational, material and technical potential of the scientific excellence of Institute and University.
Duration: 1.1.2016 - 31.12.2019

NEXTVIR - Usage of next-generation sequencing for virome analysis of medically and economically relevant organisms
Využitie sekvenovania novej generácie pre analýzu virómu medicínsky a hospodársky významných organizmov
Program: APVV
Project leader: doc. RNDr. Stanko Michal DrSc.
Duration: 1.7.2016 - 30.6.2019

Projects total: 35