Project
Institute of Chemistry
International Projects
T0P-AGRI-Network - Towards zer0 Pesticide AGRIculture : European Network for sustainability (T0P-AGRI-Network)
Čelom k nulovému používaniu pesticídov v poľnohospodárstve: Európska sieť pre udržateľnosť
| Duration: | 19. 9. 2022 - 18. 9. 2026 |
| Evidence number: | COST Action CA21134 |
| Program: | COST |
| Project leader: | Mgr. Labancová Eva PhD. |
| Annotation: | Current crop protection in EU agriculture is heavily reliant on chemical pesticides to suppress weeds, pests and pathogens. In view of the serious health and environmental consequences, European public authorities, consumers, and society at large are demanding drastically reduced use of chemical pesticides, in the context of a production of safe, high-quality and affordable food. Furthermore, farmers are calling for research and innovation solutions to protect crops with non-chemical means while maintaining a viable farm economy. A change of direction and paradigm is needed to foster this transition, emphasizing preventive crop protection based on agroecological practices that to prevent pest outbreaks and infestations. The proposed Cost Action T0P-AGRI-Network targets the transition “Towards zer0 Pesticide AGRIculture”, aiming at preparing the future of an agriculture free of synthetic pesticides and of nature-derived pesticides that negatively impact environment and human health. T0P-AGRI-Network tackles this challenge by create and organize a wide research community with the aim to form a European leading network with high and transdisciplinary expertise around the common objective of pesticide-free agriculture, with a particular focus on young scientists. To enable a redesign of the food system as a whole, T0P-AGRI-Network will promote a concerted mobilization of scientists, farmers, processing industries, public authorities and consumers by associating them closely with the activities that will be carried out in the Cost Action. |
EU4MOFs - European metal-organic framework network: combining research and development to promote technological solutions
Európska rámcová sieť kovov a organických látok: spojenie výskumu a vývoja na podporu technologických riešení
| Duration: | 2. 11. 2023 - 1. 11. 2027 |
| Evidence number: | COST Action CA22147 |
| Program: | COST |
| Project leader: | Ing. Mičová Júlia PhD. |
EURESTOP - European Network for diagnosis and treatment of antibiotic-resistant bacterial infections
Európska sieť pre diagnostiku a liečbu bakteriálnych infekcií rezistentných voči antibiotikám
| Duration: | 6. 10. 2022 - 5. 10. 2026 |
| Evidence number: | COST Action CA21145 |
| Program: | COST |
| Project leader: | Ing. Farkaš Pavol PhD. |
E-NICHE - European Network In CHEmical Ecology: translating the language of life into sustainability
Európska sieť v chemickej ekológii: preklad jazyka života do udržateľnosti
| Duration: | 6. 10. 2023 - 5. 10. 2027 |
| Evidence number: | COST Action CA22102 |
| Program: | COST |
| Project leader: | Ing. Mastihuba Vladimír PhD. |
| Annotation: | E-NICHE will help unify the different branches of chemical ecology (CE) by bringing together researchers who study natural compounds that can act as semiochemicals (i.e., communication signals). At present, collaborations among these researchers are limited because CE is an extremely fragmented field. E-NICHE will foster partnerships between (a) scientists studying aquatic and terrestrial ecosystems; (b) natural products chemists, biochemists, and ecologists; (c) vertebrate biologists and entomologists; (d) plant and animal biologists; (e) zoologists and molecular biologists; and (f) neurobiologists and microbiologists. Their interactions will generate original ideas and perspectives while simultaneously meeting societal needs, a challenge that involves the creation of new chemical formulations, novel molecules, and innovative applications for natural compounds. This work will be nourished by a deeper understanding of the living world through the lens of chemical mediation, the main system of biological communication. It will also aim to prevent the loss of the chemical biodiversity found in nature, under threat because of global changes. Consequently, E-NICHE’s overarching objective is to establish a strong, extended European CE network that catalyses international, interdisciplinary, and cross-sectoral exchanges with a view to building knowledge and intergenerational sustainable development solutions. Via the new network created by E-NICHE, researchers will broaden their breadth of knowledge, define new research directions, and transform their discoveries into pioneering solutions. |
| Project web page: | https://www.cost.eu/actions/CA22102/ |
Net4Brain - A Comprehensive Network Against Brain Cancer
Komplexná sieť proti rakovine mozgu
| Duration: | 30. 10. 2023 - 29. 10. 2027 |
| Evidence number: | COST Action CA22103 |
| Program: | COST |
| Project leader: | Ing. Květoň Filip PhD. |
MedPlants4Vet - Medicinal plants for animal health care: Translating tradition into modern veterinary medicine.
Liečivé rastliny pre starostlivosť o zdravie zvierat: Premena tradície do modernej veterinárnej medicíny
| Duration: | 12. 10. 2023 - 11. 10. 2027 |
| Evidence number: | COST Action CA22109 |
| Program: | COST |
| Project leader: | Ing. Kremnický Ľubomír PhD. |
| Annotation: | Identify and fill knowledge gaps regarding the use of medicinal plants for companion and farm animals. MedPlants4Vet will create an inventory on historical, ethnoveterinary, pharmacological, clinical and recent and past regulatory data and prepare the basis to decide future regulatory procedures on herbal veterinary medicinal products in Europe. |
GLYDIABEV - Study of extracellular vesicles glycosylation in diabetes by advanced analytical approaches for thebetter diagnosis and treatment
Štúdium glykozylácie extracelulárnych vezikúl pri diabete pokrocilými analytickými prístupmi pre lepšiu diagnostiku a liečbu
| Duration: | 1. 4. 2024 - 31. 12. 2025 |
| Evidence number: | SK-SRB-23-0048 |
| Program: | Medzivládna dohoda |
| Project leader: | Ing. Katrlík Jaroslav PhD. |
FoodWaStop - Sustainable Network for agrofood loss and waste prevention, management, quantification and valorisation
Trvalo udržateľná sieť pre straty v agropotravinárske a predchádzanie vzniku odpadu, riadenie, kvantifikáciu a zhodnocovanie
| Duration: | 21. 9. 2023 - 20. 9. 2027 |
| Evidence number: | COST Action CA22134 |
| Program: | COST |
| Project leader: | Ing. Košťálová Zuzana PhD. |
SUSTAIN - Sustainable use of salt-affected lands
Trvalo udržateľné využívanie pôdy ovplyvnenej soľou
| Duration: | 3. 10. 2023 - 2. 10. 2027 |
| Evidence number: | COST Action CA22144 |
| Program: | COST |
| Project leader: | Mgr. Vivodová Zuzana PhD. |
HAPLO-iPS - Generation of Human induced pluripotent stem cells for haplo-selected cord blood samples
Vytváranie humánnych indukovaných pluripotentných kmeňových buniek z haplo-vybraných vzoriek krvi z pupočníkovej šnúry
| Duration: | 11. 10. 2022 - 10. 10. 2026 |
| Evidence number: | CA21151 |
| Program: | COST |
| Project leader: | MSc. Ram Jadhav Santosh PhD. |
ROOT-BENEFIT - Beneficial root-associated microorganisms for sustainable agriculture
Využitie prospešných mikroorganizmov asociovaných s koreňmi rastlín za účelom zvýšenia udržateľnosti poľnohospodárstva
| Duration: | 16. 10. 2023 - 15. 10. 2027 |
| Evidence number: | COST Action CA22142 |
| Program: | COST |
| Project leader: | Mgr. Holeková Kristína PhD. |
ATBG - Development of High Sensitivity and High Resolution Analytical Tools for the Brain Glycans
Vývoj vysokocitlivých analytických nástrojov s vysokým rozlíšením pre analýzu glykánov mozgu
| Duration: | 1. 10. 2023 - 30. 9. 2026 |
| Evidence number: | V4-Kórea/JRP/2023/727/ATBG |
| Program: | JRP |
| Project leader: | Ing. Tkáč Ján DrSc. |
National Projects
EXACT DX - EXosome Analysis Complementary To Diagnostic eXaminations
Analýza exozómov ako komplementárna diagnostická metóda
| Duration: | 1. 9. 2025 - 31. 8. 2028 |
| Evidence number: | APVV-24-0065 |
| Program: | APVV |
| Project leader: | Ing. Bertók Tomáš DrSc., MBA |
| Annotation: | Cancer is one of the leading causes of deaths globally, with annual incidence of 20.0M in 2022. Moreover, the burden is estimated to grow even further to 32.6M in 2045 (Globocan data). The tumor biopsy increases the cost of patient care and in some cases the turnaround time for getting results, thus novel approaches have been developed using body fluids – so-called liquid biopsy. Among autoimmune diseases, rheumatoid arthritis is one of the most common ones with the incidence of about 150,000 to 200,000 new cases in Europe only. As well as in cancer progression, glycans play an important role in defining anti- or proinflammatory role of antibodies. So-called seronegative arthritis, a category of inflammatory joint conditions without detectable autoantibodies comprises about 15% of all patients diagnosed with rheumatoid arthritis. Since ~70+% of all diagnoses rely on laboratory tests results (according to CDC), the importance of implementing novel biomarkers is a high unmet medical need. In our previous work, we´ve developed bioanalytical devices with low detection limits for analyzing glycoproteins down to femtomolar levels and applied these platforms for the analysis of real human samples using nanostructured interfaces resistive to non-specific interactions. In this project, we will focus on the application of these findings in the area of exosome analysis, which are harder to analyze due to their heterogenic nature and relatively low stability. The ultimate goal in the glycomic analyses is the possibility to glycoprofile biomarkers of choice omitting the “heavy machinery” approach (LC-MS), but rather to extract the most crucial information about the presence/absence of cancer-associated glycan epitopes promoting cell aggressiveness and metastases in an easy-to-use, inexpensive way using a simple, high-throughput table-top platforms, such as lectin-based immunoassays. |
MAGDA - Mapping the Glycome and Glycosylated Proteins in Alzheimer's disease
Mapovanie glykómu a glykozylácie proteínov spojených s Alzheimerovou chorobu
| Duration: | 1. 9. 2025 - 31. 8. 2028 |
| Evidence number: | APVV-24-0529 |
| Program: | APVV |
| Project leader: | Ing. Ďatková Anna PhD. |
| Annotation: | Nowadays, there are 55 million people with dementia worldwide, and with the aging of the population, a sharp increase in the incidence of this disease is expected. Early diagnosis is a key aspect in the treatment of any disease. Current diagnosis of Alzheimer disease (AD) is made by analysis of proteins/peptides in cerebrospinal fluid (CSF) or blood. AD can also be diagnosed using brain imaging techniques, but such techniques are expensive and can only be performed in specialized hospitals with trained personnel. Many studies suggest that changes in glycosylation may play a key role in the pathogenesis and progression of the disease. The presented project focuses on tracking changes in glycome and glycosylation of selected glycoproteins associated with AD. The main goal of the project is to identify changes in the glycoprofile of various samples, altered glycosylation of proteins and to use this knowledge to improve AD diagnostic methods. The project methodology includes advanced glycosylation techniques, glycomics analysis and bioinformatics tools for data analysis and interpretation. We expect that the results of this project will contribute to a better understanding of the molecular mechanisms in AD and open new possibilities for diagnosis and potential treatment for such a disease. The importance of the project lies in its potential to identify new biomarkers for the early diagnosis of AD, which could fundamentally improve the prognosis and quality of life of patients. |
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Antibakteriálne katiónové polysacharidy proti rezistentným nozokomiálnym patogénom - štúdium vzťahu štruktúry a biologických vlastností
| Duration: | 1. 7. 2024 - 31. 12. 2025 |
| Evidence number: | APD0104 |
| Program: | PostdokGrant |
| Project leader: | Mgr. Madelová Romana PhD. |
CoViD - Antiviral drugs against COVID-19: Design, synthesis and biological activity testing of specific inhibitors of viral proteases of coronavirus SARS-CoV-2
Antivirálne liečivá proti COVID-19: Dizajn, syntéza a testovanie aktivity špecifických inhibítorov virálnych proteáz koronavírusu SARS-CoV-2
| Duration: | 1. 7. 2022 - 30. 6. 2026 |
| Evidence number: | APVV-21-0108 |
| Program: | APVV |
| Project leader: | Ing. Katrlík Jaroslav PhD. |
Baeyer-Villiger oxidations, immobilized cells, mechanically stirred bioreactors, pneumatically stirred bioreactors, mathematical modeling
Baeyer-Villigerove oxidácie, imobilizované bunky, mechanicky miešané bioreaktory, pneumaticky miešané bioreaktory, matematické modelovanie
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 1/0515/22 |
| Program: | VEGA |
| Project leader: | Ing. Bučko Marek PhD. |
Bioinspired oxidative coupling of natural phenols
Bioinšpirovaný oxidačný kapling prírodných fenolov
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0111/22 |
| Program: | VEGA |
| Project leader: | Ing. Mastihubová Mária PhD. |
Biosensoring devices based on functionalized micro- and nanoscale biointerfaces for glycomic analyses
Biosenzorické zariadenia založené na funkcionalizovaných mikro- a nanoškálovaných biorozhraniach pre glykomické analýzy
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0120/22 |
| Program: | VEGA |
| Project leader: | Ing. Katrlík Jaroslav PhD. |
Detailed analysis and elucidation of functions of Cka1 and Ksg1 protein kinases using the conditional ATP analog-sensitive mutants
Detailná analýza a objasnenie funkcie Cka1 a Ksg1 proteínkináz využitím ich kondičných na ATP analógy citlivých mutantov
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | VEGA 2/0021/22 |
| Program: | VEGA |
| Project leader: | Mgr. Baráth Peter PhD. |
Design, synthesis and biochemical evaluation of Golgi α-mannosidase II inhibitors
Dizajn, syntéza a biochemické testovanie selektívnych inhibítorov Golgiho α-manozidázy II
| Duration: | 1. 1. 2023 - 31. 12. 2026 |
| Evidence number: | 2/0010/23 |
| Program: | VEGA |
| Project leader: | Ing. Bella Maroš PhD. |
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Glykozidhydrolázy rodín 16,28 a 72 - ich charakterizácia, štruktúra a funkcia v bunkových stenách rastlín a húb
| Duration: | 1. 1. 2024 - 31. 12. 2027 |
| Evidence number: | 2/0162/24 |
| Program: | VEGA |
| Project leader: | Mgr. Kozmon Stanislav PhD. |
In vivo enzyme immobilization applied in the synthesis of hyaluronic acid
In vivo imobilizácia enzýmov aplikovaná v syntéze kyseliny hyalurónovej
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0064/22 |
| Program: | VEGA |
| Project leader: | Ing. Nahálka Jozef PhD. |
Innovative 2D Nanomaterial-Enhanced Biosensors And Enzymatic Platforms: The Future of Specialty Chemical Production
Inovatívne 2D nanomateriálmi vylepšené biosenzory a enzymatické platformy: Budúcnosť výroby špeciálnych chemikálií
| Duration: | 1. 1. 2026 - 31. 12. 2029 |
| Evidence number: | 2/0004/26 |
| Program: | VEGA |
| Project leader: | Ing. Hrončeková Štefánia PhD. |
| Annotation: | This project focuses on developing goldene, an innovative nanomaterial, and other 2D nanomaterials such as MXenes for the design of ultrasensitive electrochemical nanobiosensors. These will enable advanced analysis of multienzyme cascade reactions for producing specialty chemicals, particularly epsilon-caprolactone. Compared to conventional methods, the new biosensors will offer faster monitoring, flexible process control, and reduced solvent consumption. The project includes goldene synthesis, electrochemical studies, biosensor development and bioelectrochemical testing, followed by validation on real biotransformation samples. Research will also continue on epsilon-caprolactone production using both free and immobilised recombinant E. coli BL21 (DE3) cells with co-expressed enzyme cascades. Integrating novel 2D nanomaterials, advanced electrochIntegrating novel 2D nanomaterials, advanced electrochemical/characterisation methods, bioreactor engineering, and immobilisation will optimise biosensor performance. |
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Inovované imobilizované biokatalyzátory na báze Baeyer-Villigerových monooxygenáz, enzýmových kaskád a hydroláz epoxidov pre ekologickú prípravu chemických specialít
| Duration: | 1. 1. 2024 - 31. 12. 2027 |
| Evidence number: | 2/0164/24 |
| Program: | VEGA |
| Project leader: | Ing. Bučko Marek PhD. |
TEAMB - Joint theoretical and experimental approaches to address modern challenges of molecular biology.
Integrácia teoretických a experimentálnych prístupov pri riešení moderných výziev molekulárnej biológie.
| Duration: | 1. 1. 2023 - 31. 12. 2026 |
| Evidence number: | 2/0061/23 |
| Program: | VEGA |
| Project leader: | Ing. Sládek Vladimír PhD. |
Interaction of saccharide epitopes of epidemiologically interesting Candida species with C-type lectins
Interakcie sacharidovývh epitopov epidemiologicky zaujímavých druhov Candida s lektínmi typu C
| Duration: | 1. 1. 2023 - 31. 12. 2026 |
| Evidence number: | 2/0094/23 |
| Program: | VEGA |
| Project leader: | Ing. Farkaš Pavol PhD. |
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Izolácia, purifikácia, charakterizácia a využitie diglykozidáz
| Duration: | 1. 8. 2024 - 31. 12. 2025 |
| Evidence number: | APD0057 |
| Program: | PostdokGrant |
| Project leader: | Ing. Haluz Peter PhD. |
Cationic polysaccharides as potential antibacterial agents for direct and combination therapies of infections caused by resistant pathogens
Katiónové polysacharidy ako potenciálne antibakteriálne agensy pre priamu a kombinovanú terapiu infekcií spôsobených rezistentnými patogénmi
| Duration: | 1. 1. 2025 - 31. 12. 2028 |
| Evidence number: | VEGA 2/0061/25 |
| Program: | VEGA |
| Project leader: | Ing. Čížová Alžbeta PhD. |
Phylloplane and pedobiont yeasts as beneficial agens for plants
Kvasinky z fylosféry a pôdy ako užitočné agensy pre rastliny
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0151/22 |
| Program: | VEGA |
| Project leader: | Ing. Vadkertiová Renáta PhD. |
Microscopic cyanobacteria and algae as an important source of exopolysaccharides
Mikroskopické sinice a riasy ako významný zdroj exopolysacharidov
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0054/22 |
| Program: | VEGA |
| Project leader: | Mgr. Capek Peter PhD. |
MOSBAPA - Modification of surfaces as barrier to protein adsorption
Modifikácia povrchov ako bariéra pre adsorpciu proteínov
| Duration: | 1. 7. 2022 - 30. 6. 2026 |
| Evidence number: | APVV-21-0346 |
| Program: | APVV |
| Project leader: | Mgr. Kozmon Stanislav PhD. |
Insight into the immunobiological properties of Candida albicans extracellular vesicles (EVs) cargo with a focus on active carbohydrate molecules important for host-pathogen interaction
Nahliadnutie do imunobiologických vlastností obsahu extracelulárnychvezikúl (EVs) Candidaalbicans so zameraním na aktívne molekuly sacharidov dôležité pre interakciu hostiteľ-patogén
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00680 |
| Program: | Plán obnovy EÚ |
| Project leader: | Ing. Paulovičová Lucia PhD. |
GlycoDynamarkers - Uncharted Glycosylation Complexity: Investigation of its Dynamic Mechanisms and Disease-Relevant Glycobiomarkers
Nezmapovaná komplexnosť glykozylácie: Výskum jej dynamických mechanizmov a glykobiomarkerov relevantných pre ochorenia
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00681 |
| Program: | Plán obnovy EÚ |
| Project leader: | Ing. Pakanová Zuzana PhD. |
Novel enzymes for the decomposition of the most recalcitrant epitopes of plant polysaccharides
Nové enzýmy pre rozklad najneprístupnejších epitopov rastlinných polysacharidov
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0171/22 |
| Program: | VEGA |
| Project leader: | Mgr. Puchart Vladimír PhD. |
| Annotation: | This project is a continuation of long-term successful effort of the authors’ group to expand current knowledge on microbial enzymes involved in plant cell wall degradation. The project is a part of a world-wide effort to develop processes for a complete exploitation of this annually renewable source of carbon and energy.. The project will study substrate specificity and regioselectivity of novel, poorly examined xylanases as well as auxiliary xylanolytic enzymes, specifically, beta-xylosidases, alpha-glucuronidases, alpha-L-arabinofuranosidases, and acetylxylan esterases, and relate them to their structural diversity. The project will be focused on the degradation of the most recalcitrant epitopes originating from xylans of various types as the most abundant plant hemicellulose. The unraveling of so far unknown action will contribute to a development of efficient and environment-friendly industrial processes of biodegradation and bioconversion of plant biomass and its conversion to beneficial products. |
ENZYEAST - Novel yeast enzymes for bioconversion of plant biomass
Nové kvasinkové enzýmy na biokonverziu rastlinnej biomasy
| Duration: | 1. 7. 2023 - 30. 6. 2027 |
| Evidence number: | APVV-22-0207 |
| Program: | APVV |
| Project leader: | Ing. Šuchová Katarína PhD. |
MIGLYTECH - -
Nové prístupy na zlepšenie microarray detekčnej technológie pre vysokovýkonnú glykotypizáciu
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09/03-03-V04-00772 |
| Program: | Plán obnovy EÚ |
| Project leader: | Ing. Katrlík Jaroslav PhD. |
M(A)X4biosens&Gl - Advanced 2D nanoscaled "MXene" interfaces as perspective immobilisation platforms for design of (bio)sensors for cancer biomarkers detection and glycan enrichment
Pokročilé 2D nanorozmerné "MXénové" rozhrania ako perspektívne imobilizačné platformy pre návrh (bio)senzorov na detekciu biomarkerov rakoviny a obohatenie glykánov
| Duration: | 1. 7. 2023 - 30. 6. 2027 |
| Evidence number: | 40213514 |
| Program: | APVV |
| Project leader: | RNDr. Lorencová Lenka PhD. |
OriFlame - Origin and function of novel meningeal subpopulation of Lyve1 macrophages in health and disease
Pôvod a funkcia nových meningeálnych Lyve1 pozitívnych makrofágov v zdraví a chorobe
| Duration: | 1. 7. 2024 - 30. 6. 2028 |
| Evidence number: | APVV-23-0628 |
| Program: | APVV |
| Project leader: | MSc. Ram Jadhav Santosh PhD. |
Preparation of new biologically active substances in streptomycetes by genetic interventions in the genome and methods of synthetic biology
Príprava nových biologicky aktívnych látok u streptomycét genetickými zásahmi do genómu a metódami syntetickej biológie
| Duration: | 1. 9. 2025 - 31. 8. 2029 |
| Evidence number: | APVV-24-0023 |
| Program: | APVV |
| Project leader: | Ing. Šoral Michal PhD. |
| Annotation: | Bacteria of the genus Streptomyces are important producers of biologically active substances with a wide spectrum of activities. The genes responsible for their production are physically grouped in the so-called biosynthetic gene clusters (BGCs). The aim of this project is to prepare and characterize new biologically active substances by activating silent BGCs through genetic interventions in the genome and synthetic biology methods. This project builds upon the previous APVV project, in which we identified 30 BGCs responsible for novel secondary metabolites that remain silent under laboratory conditions in our strain S. lavendulae subsp. lavendulae CCM 3239. We optimized the activation system by inserting an antibiotic resistance cassette with a strong promoter upstream of the genes in three selected BGCs, leading to the identification of new biologically active compounds. The first aim of this project will be to activate additional BGCs using this system. Another aim is to activate BGCs responsible for unknown secondary metabolites in the model strain S. venezuelae ATCC 10712, where 34 BGCs have been identified, most of which remain silent. For this strain, we will develop a new activation system by markerless insertion of a strong promoter upstream of multiple genes within these BGCs. In the previous APVV project, we successfully introduced a new synthetic biology system based on the creation of artificial BGCs by sequentially joining monocistronic units, which was validated for the antibiotics landomycin and mithramycin. One of the goals of the project is to use this system for the production of a more effective intermediate, mithramycin SK, as well as for jadomycin derivatives and new aromatic polyketides by combining biosynthetic genes from other polyketide antibiotics. Our results will contribute to the understanding of secondary metabolite biosynthesis and may lead to the discovery of new biologically active substances with effective therapeutic properties. |
Progressive Approaches in Prostate Cancer Diagnosis Through the Integration of Advanced Techniques - Magnetic Separation and FRET Detection
Progresívne prístupy v diagnostike rakoviny prostaty prostredníctvom prepojenia pokročilých techník - magnetickej separácie a detekcie FRET
| Duration: | 1. 7. 2024 - 31. 12. 2025 |
| Evidence number: | APD0075 |
| Program: | PostdokGrant |
| Project leader: | Ing. Ďatková Anna PhD. |
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Purifikácia a kryštalizácia nešpecifickej xyloglukán endotransglykozylázy
| Duration: | 1. 7. 2024 - 31. 12. 2025 |
| Evidence number: | APD0010 |
| Program: | PostdokGrant |
| Project leader: | Mgr. Stratilová Barbora PhD. |
Synthesis of nanocomposites of transition metal oxides, study of the influence of plasma on their photocatalytic efficiency with application in wastewater treatment
Syntéza nanokompozidov oxidov prechodných kovov, štúdium vplyvu plazmy na ich fotokatalytickú účinnosť s uplatnením pri čistení odpadových vôd
| Duration: | 1. 1. 2023 - 31. 12. 2025 |
| Evidence number: | 2/0132/23 |
| Program: | VEGA |
| Project leader: | Ing. Mičová Júlia PhD. |
Synthesis, physicochemical, biological properties of glycoconjugates, N-heterocycle-based precursors and polysaccharide derivatives as potential anticancer and antiviral agents
Syntéza, fyzikálno-chemické a biologické vlastnosti prekurzorov na báze glykokonjugátov, N-heterocyklov a derivátov polysacharidovako potenciálnych antikarcinogénnych a antivirotických liečiv
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0071/22 |
| Program: | VEGA |
| Project leader: | Ing. Hricovíni Miloš PhD. |
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Štipendiá pre excelentných PhD. študentov a študentky (R1) / Vývoj a aplikácia moderných metód pre detekciu glykánových biomarkerov
| Duration: | 1. 9. 2023 - 30. 6. 2026 |
| Evidence number: | 09I03-03-V02-00049 |
| Program: | Plán obnovy EÚ |
| Project leader: | Ing. Dudoňová Patrícia |
MitoTransport - The effect of pathologic mutations and post-translational modifications onthe functions of mitochondrial pocessing peptidase essential for transport to mitochondria
Účinok patologických mutácií a posttranslačných modifikácií na funkcie mitochondriálnej procesujúcej peptidázy nevyhnutnej pre transport do mitochondrií
| Duration: | 1. 7. 2024 - 30. 6. 2028 |
| Evidence number: | APVV-23-0407 |
| Program: | APVV |
| Project leader: | Mgr. Baráth Peter PhD. |
Investigation of substances and factors with a potential effect on the pathogenicity of various strains of bacterium Paenibacillus larvae causing American foulbrood
Výskum látok a faktorov s potenciálnym vplyvom na patogenicitu rôznych kmeňov baktérie Paenibacillus larvae spôsobujúcej mor včelieho plodu
| Duration: | 1. 1. 2023 - 31. 12. 2026 |
| Evidence number: | 2/0139/23 |
| Program: | VEGA |
| Project leader: | RNDr. Klaudíny Jaroslav PhD. |
The utilisation of indigenous microorganisms and natural compounds for improvement of seed germination, plant growth and the amelioration of the abiotic stress
Využitie pôvodných mikroorganizmov a prírodných zlúčenín na zlepšenie klíčenia, rastu rastlín a na zmiernenie abiotického stresu
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0055/22 |
| Program: | VEGA |
| Project leader: | RNDr. Kollárová Karin PhD. |
NANOSENSE - Golden(e) approach: Next-generation of 2D nanomaterial-enabled advanced biosensors and immobilised systems using enzymes and viable whole cells with enzyme cascades for use in production of chemical specialties
Zlatý prístup: Nová generácia 2D pokročilých biosenzorov s podporou nanomateriálov a imobilizované systémy využívajúce enzýmy a viabilné celé bunky s enzýmovými kaskádami na produkciu chemických špecialít
| Duration: | 1. 9. 2025 - 31. 8. 2029 |
| Evidence number: | APVV-24-0185 |
| Program: | APVV |
| Project leader: | Ing. Hrončeková Štefánia PhD. |
| Annotation: | The project solution is aimed at obtaining new knowledge from the point of view of the preparation of the innovative nanomaterial goldene, the use of nanomaterials based on MXenes and others for the design of ultrasensitive amperometric biosensors and their use for advanced analysis of multienzyme cascade reactions for the production of chemical specialties. The use of new biosensors will enable faster monitoring, more flexible management of cascade reactions compared to the conventional analytical procedures and potential and environmentally beneficial reduction in the consumption of harmful solvents. Biofunctionalisation of the biosensor surface with a high density of cells/cofactors/enzymes will ensure high sensitivity of the developed biosensors. Characterisation of step-by- step development of biosensors and testing of their bioelectrochemical activity will precede validation using real samples from biotransformations. Part of the project will be the continuation of research and development of new immobilisation procedures of recombinant E. coli cells with co-expressed enzyme cascades as well as individual enzymes of the cascades. When solving the project, bioreactor engineering methods, advanced biopolymer materials and the most modern photonics methods will be used in cooperation with top partners in order to characterise and set optimal biocatalytic parameters of cascade reactions for the model production of chemical specialties. |
Projects total: 49