PhD. Topics
Centre of Experimental Medicine SAS
Topic
Development and Application of In Vitro Methods for the Assessment of Inhalation Toxicity of Selected Chemical Substances and Pharmaceuticals
PhD. program
Biochemistry
Year of admission
2025
Name of the supervisor
Dr.rer.nat., Ing. Helena Kanďárová, ERT
Contact:
Receiving school
Faculty of Chemical and Food Technology STU
Annotation
The aim of this doctoral thesis is to develop and optimize in vitro methods for assessing the inhalation
toxicity of selected chemical substances and pharmaceutical products. The research will focus on the use
of 3D reconstructed airway models and other advanced experimental systems that enable realistic
simulations of inhalation exposure. The study will include the validation of methods according to
international standards and their application in evaluating the potential toxic effects on the respiratory
system. The results will contribute to improving the predictive value of in vitro tests and advancing
alternative testing methods in line with the principles of the 3Rs (Replacement, Reduction, Refinement).
toxicity of selected chemical substances and pharmaceutical products. The research will focus on the use
of 3D reconstructed airway models and other advanced experimental systems that enable realistic
simulations of inhalation exposure. The study will include the validation of methods according to
international standards and their application in evaluating the potential toxic effects on the respiratory
system. The results will contribute to improving the predictive value of in vitro tests and advancing
alternative testing methods in line with the principles of the 3Rs (Replacement, Reduction, Refinement).