Project
Centre for Advanced Materials Application SAS
International Projects
DAEMON - -
Aplikácia založeného na údajoch smerom k inžinierstvu funčných materiálov: otvorená sieť
| Duration: | 1. 9. 2023 - 30. 9. 2027 |
| Evidence number: | COST CA22154 |
| Program: | COST |
| Project leader: | Mgr. Nada Ahmed Ali Ahmed Haggag PhD. |
G-Virals - Viral RNA-protein interaction on graphene-based field effect transistors as a new avenue for viral surveillance
Interakcia vírusovej RNA-proteínu na tranzistoroch s efektom poľa na báze grafénu ako nová cesta pre dohľad nad vírusmi
| Duration: | 1. 2. 2024 - 31. 1. 2027 |
| Program: | ERANET |
| Project leader: | Mgr. Hvizdošová Annušová Adriana PhD. |
PVKSC - Beyond 27% perovskite solar cells: A deep study based on in-situ charge dynamics and crystal growth kinetics
Perovskitové solárne články s účinnosťou nad 27%: Hĺbková štúdia založená na in-situ dynamike náboja a kinetike rastu kryštálov
| Duration: | 1. 10. 2023 - 30. 9. 2026 |
| Evidence number: | 2023/727/PVKSC |
| Program: | JRP |
| Project leader: | RNDr. Mrkývková Naďa PhD. |
| Annotation: | The aim of this project is to develop high-performance and robust FAPbI3-based solar cells with efficiencies in excess of 27% and to study the phase conversion, charge carrier dynamics and loss mechanisms occurring in the solar cell, using the expertise of all partners. |
Na-CerAnode - Ceramic Anode Host Material For confined Sodium Plating
Porézny keramický anódový materiál pre sodíkové pokovovanie
| Duration: | 1. 7. 2024 - 30. 6. 2027 |
| Evidence number: | ERANET 3/2023/912.C |
| Program: | ERANET |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
-
Tuholátková lítiová batéria s in situ hybridným elektrolytom
| Duration: | 1. 7. 2023 - 30. 6. 2026 |
| Evidence number: | H2020RIA |
| Program: | Iné |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
SEATBELT - Solid-statE lithium metal bAttery wiTh in situ hyBrid ELecTrolyte Hop-On
Tuholatková lítiová kovová batéria s in situ hybridným elektrolytom
| Duration: | 1. 6. 2022 - 31. 5. 2026 |
| Evidence number: | 101069726 |
| Program: | Horizont Európa |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | Electric vehicles are powered by batteries, which are the most important part. But the demand for electric vehicles is increasing so fast that it will soon outpace battery cell production. The EU-funded SEATBELT project will help to pave the road towards a cost-effective, robust all-solid-state lithium battery comprising sustainable materials by 2026. Specifically, it will achieve the first technological milestone of developing a battery cell that meets the needs of the electric vehicle industry. The low cost cell will be safe by design with sustainable and recyclable materials, reaching high energy densities and long cyclability in line with the 2030 EU targets. The project will be the start point of the first EU all solid-state battery value chain. |
| Project web page: | https://seatbelt-project.eu |
SUSHIBATT - Sustainable High-Voltage Batteries Based on Hybrid Cathodes Enabling Dual-Ion Energy Storage
Udržateľné vysoko-napäťové batérie založené na hybridných katódach umožňujúce uskladanie energie pomocou duálnych iónov
| Duration: | 1. 4. 2024 - 31. 3. 2027 |
| Evidence number: | ERA-NET 3/2023/912.C |
| Program: | ERANET |
| Project leader: | Ing. Fröhlich Karol DrSc. |
AI-SCOPE - AI-Driven Enhancement of Surface Scattering Data for Open Science Platforms Across Europe
Vylepšovanie údajov o povrchovom rozptyle založené na umelej inteligencii pre platformy otvorenej vedy v Európe
| Duration: | 1. 12. 2024 - 30. 11. 2026 |
| Evidence number: | 01-154 |
| Program: | Horizont Európa |
| Project leader: | RNDr. Mrkývková Naďa PhD. |
| Annotation: | The AI-SCOPE project engages the European photon and neutron science community to enhance the frequency and quality of FAIR-compliant data submissions to EOSC-indexed databases such as ESRF data portal or Zenodo, which currently only feature on the order of 100 entries in surface scattering. Our tri-national team will introduce a sophisticated AI analysis tool for surface scattering experiments that not only performs an automated initial analysis but simultaneously generates rich metadata annotations. This dual capability incentivizes researchers to utilize the tool, as it streamlines their workflow and gives “live” feedback during experimental sessions at large scale facilities (“beamtimes”) to avoid wasted time at research infrastructures. Crucially, the AI-tool will be designed to use AI to estimate structural sample parameters (like film thickness, material densities, contact planes and unit cell dimensions) and input these into the database using standardized metadata formats. This feature ensures the database can be searched for specific materials and structures from the automated AI analysis, thereby avoiding the pitfalls of a hard-to-use raw data dump and increasing reusability within the scientific ecosystem of EOSC / PaNOSC. The project, therefore, stands to dramatically enhance data FAIRness and beamtime efficiency. Moreover, the three collaborating research groups will rigorously apply the tool to a diverse array of their pre-existing scattering data from a multitude of sample types. This will result in the creation of a well-curated dataset with detailed annotations in EOSC-indexed databases, laying the groundwork as a resource for future research endeavors in AI-guided materials discovery. Both our AI-tool and the curated database will unlock new possibilities for data reuse and collaborative scientific exploration of X-ray and neutron data with machine learning. |
| Project web page: | https://oscars-project.eu/projects/ai-scope-ai-driven-enhancement-surface-scattering-data-open-science-platforms-across |
OPERA - DEVELOPMENT OF OPERANDO TECHNIQUES AND MULTISCALE MODELLING TO FACE THE ZEROEXCESS SOLID-STATE BATTERY CHALLENGE
VÝVOJ OPERANDO TECHNÍK A VIACROZMERNÉHO MODELOVANIA S CIEĽOM ČELIŤ VÝZVE TÝKAJÚCEJ SA BEZANÓDOVÝCH PEVNOLÁTKOVÝCH BATÉRIÍ
| Duration: | 1. 6. 2023 - 31. 5. 2026 |
| Evidence number: | 101103834 |
| Program: | Horizont Európa |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | Green, high-performing and safe batteries based on abundant materials are a key element in the transition to a carbon-neutral future. However, to accelerate their development, a deep understanding of the complex electro-chemo-mechanical processes within the battery is required, which is only accessible through advanced experimental and computational methods. Zero-excess solid-state batteries, where the anode is formed in situ, have emerged as a promising new generation of environmentally friendly batteries with high energy density, improved safety and higher cost-efficiency, but only after solutions for non-uniform anode formation were found. |
| Project web page: | https://horizon-opera.eu |
-
Vývoj operando techník a viacrozmerného modelovania s cieľom reagovať na výzvu týkajúcu sa tuholátkových batérií bez prebytku lítia
| Duration: | 1. 6. 2023 - 31. 5. 2026 |
| Evidence number: | H2020RIA |
| Program: | Iné |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
SOLIMEC - Enhancing the Mechanical Stability of Interfaces in Solid-state Li-ion Batteries for Energy-intensive Applications
Zvýšenie mechanickej stability rozhraní v pevnolátkových lítium-iónových batériách pre energeticky náročné aplikácie
| Duration: | 1. 5. 2022 - 30. 4. 2025 |
| Evidence number: | ERA-NET |
| Program: | ERANET |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | The Glasgow 2021 climate conference highlighted the importance of reducing CO2 emissions. These efforts require a stronger move towards sustainable energy sources and storage. The rationale for this project is to advance a new generation of emerging solid-state Li batteries (SSLB) that can eliminate the risks and energy density issues associated with conventional liquid electrolyte-based Li-ion batteries (LIBs). To achieve this goal, five leading research groups and a major EU technology company have developed the following strategy to address the current SSLB challenges. We rely on multicomponent engineering of the cathode material and its interface with the solid electrolyte to prevent voltage-induced contact loss during charge/discharge, which impairs electron/ion transfer, and thus improve SSLB performance and lifetime. Potential benefits are seen in the use of SSLBs as a real alternative to LIBs to replace fossil fuels in the automotive industry. |
National Projects
POREBAT - -
Aplikácia poréznych tuholátkových elektrolytov pre bezanódové batérie novej generácie
| Duration: | 1. 7. 2024 - 30. 6. 2026 |
| Evidence number: | 09I01-03-V04-00001 |
| Program: | Plán obnovy EÚ |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
ZERO - Zero-excess solid-state lithium batteries
Bezanódové tuholátkové lítiové batérie
| Duration: | 1. 7. 2023 - 31. 12. 2026 |
| Evidence number: | APVV-22-0132 |
| Program: | APVV |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | The central hypothesis of ZERO project is that by real -time monitoring of Li deposition rate, wetting and/or alloying, and mechanical stress at the SSE/CC interface, we can optimize and tailor SSBs providing higher capacity and cycling lifetime. This can be achieved by controlling charge/discharge currents, appropriate alloy-forming interlayers, and managing internal stresses by external loads. The main aim of ZERO project is to develop optimal alloy-forming interlayers and charging strategies to achieve the high capacity and cycling lifetime of ZESSBs. This will be enabled and connected with the developing and/or updating methodologies that will facilitate experimental monitoring and a better conceptual understanding of the growth phenomena involved in the formation of the Li anode in ZESSBs. To this end, we will develop novel laboratory and synchrotron techniques to explore ZESSB-related phenomena under in operando conditions. |
ECOINNOCATALYSTS - Eco-Friendly Surface Modification of Electrode Materials in Deep Eutectic Solvents: An Innovative Strategy for Enhancing Photo- and Electrocatalysts for the Hydrogen Evolution Reaction
Ekologická úprava povrchov elektrodových materiálov v hlbokých eutektických rozpúšťadlách: Inovatívna stratégia na zlepšenie foto- a elektrokatalyzátorov pre reakciu vývoja vodíka
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00020 |
| Program: | Plán obnovy EÚ |
| Project leader: | doc. Mgr. Kityk Anna PhD. |
| Annotation: | The project “Eco-Friendly Surface Modification of Electrode Materials in Deep Eutectic Solvents: An Innovative Strategy for Enhancing Photo- and Electrocatalysts for the Hydrogen Evolution Reaction” is a two-year research project focused on advancing the development of efficient photo- and electrocatalysts for the Hydrogen Evolution Reaction (HER). This research aims to investigate the kinetic and mechanisms of electrodeposition, electrooxidation, and electroless deposition of photo- and electroactive layers on cost-effective substrates using eco-friendly electrolytes, specifically room-temperature deep eutectic solvents (DESs). The ultimate goal is to produce high-performance cathode materials for the eco-friendly production of “green” hydrogen. The project addresses the critical need for sustainable hydrogen production via electrolysis using renewable energy sources. While the HER is well-studied, the search for cost-effective, abundant, and durable electrode materials with comparable or superior catalytic activity to noble metals remains essential. Noble metals are limited by their cost, availability, durability, and susceptibility to catalyst poisoning. This research project focuses on three main objectives: 1. Investigating the electrooxidation processes of titanium and its alloys in DESs to produce highly organized nanostructured titanium dioxide layers with excellent photocatalytic activity for HER. 2. Studying the electrochemical deposition of nickel, cobalt, Ni-Co alloys, and their composites onto non-noble metal substrates and conductive carbon-based materials to create efficient electrocatalytic and photoelectrocatalytic coatings for HER. 3. Characterizing the electroless deposition of electrocatalysts based on cobalt, nickel, Ni-Co alloys, and platinum group metals onto various substrates to obtain highly efficient electrocatalysts for HER. Each objective involves determining kinetic parameters, such as rate constants and activation energies, and understanding the underlying mechanisms. The catalytic activity of newly developed electrode materials will be evaluated by assessing parameters like hydrogen evolution overpotential and exchange current density in different aqueous solutions. The project utilizes DESs known for their attractive physicochemical properties, stability, and biodegradability, ensuring an eco-friendly approach. Methodologically, the project uses advanced techniques including electrochemical methods, spectral analysis (SEM, AFM, TEM, FTIR, Raman spectroscopy, EDS, XRD, and XPS), and chemical analysis (AAS, ICP, XRF) to comprehensively investigate and characterize electrode materials and coatings. Statistical methods will aid in data analysis and interpretation. The research team embraces multi- and interdisciplinary approaches, open science principles, FAIR data access, and gender equality in research to ensure robust and collaborative scientific progress. The project's expected outcomes include the development of theories describing design and properties of innovative photo- and electrocatalysts, a diverse and cohesive research team, enhanced research capabilities, and increased visibility for young scientists. Ultimately, this project contributes to advancing sustainable hydrogen production and supports the EU's and SK's commitment to a green hydrogen economy. |
| Project web page: | https://ecoinnocatalysts.cms.webnode.sk/ |
NanoGlow - Nanoengineered Trojan hybrid for site-responsive phototherapy of recurrent glioblastomas
Fototerapia rekurentných glioblastómov s nádorovo špecifickým trójskym hybridom optimalizovaným na nano-úrovni
| Duration: | 1. 9. 2024 - 30. 6. 2028 |
| Evidence number: | APVV-23-0535 |
| Program: | APVV |
| Project leader: | Mgr. Hvizdošová Annušová Adriana PhD. |
| Annotation: | The NanoGlow project aims to develop i) functional “Trojan horse” hydrogels with embedded photothermal nanoparticle conjugates, ii) validated in vitro and iii) complemented with state-of-the-art structural and chemical mapping at the nanoscale. Photothermal, pH-responsive MoOx nanoparticles will be conjugated with tumor-homing RGD peptides and embedded in nontoxic, biodegradable poly-(2-oxazoline)- and bio-sourced Tulipalin A-based matrices. Near-field nanoscopy, Atomic Force Microscopy Force Spectroscopy, and Confocal Raman Microscopy of nanoconjugate-hydrogel superstructures and in vitro samples will characterize nanoscale related phenomena observable at the macroscale. NanoGlow’s unique nano-to-macro approach will provide a basis for the application of the proposed hybrid structures in the fight against complex and hard-to-treat glioblastomas. |
C3VIN - Charge Carrier Chemistry and Visualisation via Infrared Nanoscopy
Chémia nosičov náboja a vizualizácia prostredníctvom infračervenej nanoskopie
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00285 |
| Program: | Plán obnovy EÚ |
| Project leader: | Ing. Kálosi Anna PhD. |
NanoMaP - Nanoscale engineering and optimization of matrix embedded photothermal nanoconjugates
Nanoinžinierstvo a optimalizácia fototermálnych nanočastíc integrovaných do matríc
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00297 |
| Program: | Plán obnovy EÚ |
| Project leader: | Mgr. Hvizdošová Annušová Adriana PhD. |
-
Nová lacná a bio aktívna alkalicky aktivovaná tvrdá keramika pre ortopedické protézy a implantáty
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00287/2024/VA |
| Program: | Plán obnovy EÚ |
| Project leader: | Ing. Taveri Gianmarco PhD. |
EFFPERO - Optimizing Perovskite Films for Highly Efficient and Stable Photovoltaics
Optimalizácia perovskitových vrstiev pre vysoko účinnú a stabilnú fotovoltiku
| Duration: | 1. 7. 2024 - 30. 6. 2029 |
| Evidence number: | IM-2023-82 |
| Program: | IMPULZ |
| Project leader: | RNDr. Mrkývková Naďa PhD. |
| Annotation: | The steadily increasing energy consumption calls for renewable technologies that could substitute environmentally detrimental and costly fossil fuels. These technologies must satisfy environmental, economic, and social feasibility criteria. Perovskite-based solar modules show the ability to meet these fundamental requirements. Recently, the power conversion efficiency (PCE) of a single-junction solar cell based on halide perovskite has reached 25.7 % , and the perovskite/silicon tandems over 33 % , greatly outperforming the silicon solar cells efficiencies. Further efficiency improvement is prevented by defects that cause non-radiative recombinations – either through trap-assisted recombination in the active layer or via carrier recombination at the perovskite/transport layer interfaces. This proposal focuses on the defects in halide perovskite and related phenomena that are critical in limiting performance in photovoltaic applications. Furthermore, it aims to develop effective passivation routes to achieve further performance advances. Its innovation potential lies in increasing the efficiency of future photovoltaic applications via addressed investigation of the non-radiative traps at the grain boundary surfaces and interfaces and their efficient passivation. |
| Project web page: | https://www.youtube.com/watch?v=sadrMzCU0cY&t=17s |
SUPERPASS - Perovskite-based Films with Superior Passivation and Structure
Perovskitové vrstvy s vylepšenou pasiváciou a štruktúrou
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | APVV-SK-CZ-RD-21-0043 |
| Program: | APVV |
| Project leader: | RNDr. Mrkývková Naďa PhD. |
| Annotation: | It was found that charge recombination plays a significant role in restricting the performance of potential perovskite-based applications, which usually happens in the presence of defect states. It is generally accepted that the perovskite defects are responsible for most of the issues that hinder the further commercial usage of perovskite-based devices. This indicates that the direction of further efficiency increase lies in the addressed defects passivation. Therefore, this project focuses on a detailed investigation of defect-induced nonradiative recombination processes in perovskite films and subsequent passivation of the defect states. |
FUNBIOM - Advanced functional polymers from biorenewable monomers
Pokročilé funkčné polyméry z bioobnoviteľných monomérov
| Duration: | 1. 7. 2024 - 30. 6. 2028 |
| Evidence number: | APVV-23-0534 |
| Program: | APVV |
| Project leader: | Mgr. Švastová Eliška PhD. |
BATAX - Towards lithium based batteries with improved lifetime
Pokročilé lítiové batérie s dlhou životnosťou
| Duration: | 1. 7. 2021 - 30. 6. 2025 |
| Evidence number: | APVV-20-011 |
| Program: | APVV |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | With the steadily increasing energy requirements of portable electronics and electromobility, conventional lithiumion batteries are facing new challenges. In the proposed project, we aim to stabilize the capacity and lifetime of lithium-ion batteries employing ultra-thin interfacial layers prepared by means of atomic layer deposition (ALD). The primary functions of interfacial layers are: i) preventing the dissolution of the cathode materials into electrolyte and ii) stabilizing the cathode morphology during lithiation and de-lithiation. Although the positive effect of ALD fabricated interfacial layers has already been demonstrated, systematic studies are still missing. The main bottleneck of such studies is the identification of appropriate feedback analytical techniques that enable real-time and in-operando insights into the charging/discharging mechanisms on the nanoscale. The conventional electrochemical characterization methods can only provide hints on the ongoing mechanism during degradation processes. Here we propose to utilize in-operando small-angle and wide-angle X-ray scattering (SAXS, WAXS) to track the morphology and phase changes that occur during the charging/discharging of lithium-ion batteries in realtime. The main focus of this project is on the application of real-time SAXS/WAXS studies under laboratory conditions. In these circumstances, extensive, systematic studies of various ALD interfacial layers can be performed. |
POLYZERO - -
Polymérne tuholátkové batérie bez prebytočného lítia
| Duration: | 1. 7. 2024 - 30. 6. 2026 |
| Evidence number: | 09I01-03-V04-00002 |
| Program: | Plán obnovy EÚ |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
Comparison between silibinin-conjugated gold nanospheres and nanobipyramids impacts on the treatment of liver fibrosis in vivo.
Porovnanie účinku nanosfér a nanobipyramíd zlata konjugovaných so silibinínom pri liečbe fibrózy pečene in vivo.
| Duration: | 1. 1. 2022 - 31. 12. 2025 |
| Evidence number: | 2/0116/22 |
| Program: | VEGA |
| Project leader: | Mgr. Šelc Michal PhD. |
| Annotation: | Liver fibrosis occurs as a result of chronic liver damage associated with the accumulation of extracellular matrix proteins. It is the common outcome of various infectious and non-infectious diseases and represents a global health problem resulting from the high global prevalence and limited treatment options. Treatment of liver fibrosis is essential to prevent the development of liver cirrhosis and hepatocellular carcinoma, however, there is no effective pharmaceutical intervention to date for the treatment of this disease. One of the promising but yet barely explored approach to treat the liver fibrosis is offered by the targeted therapy using nanomaterials coated with an antifibrotic drug. In case of inorganic nanomaterials, spherical gold nanomaterials are being investigated for this aim. Interestingly nanomaterials of other shapes (e.g. nanobipyramids) could possess even better diagnostic and therapeutic features due to their unique physical-optical properties. |
The anti-cancer effects of isosilybin B-coated 5 nm core gold nanospheres against hepatocellular carcinoma
Protirakovinové účinky 5 nm nanosfér zlata obalených izosilybínom B proti hepatocelulárnemu karcinómu
| Duration: | 1. 9. 2024 - 31. 8. 2026 |
| Evidence number: | 09I03-03-V04-00283 |
| Program: | Plán obnovy EÚ |
| Project leader: | Mgr. Šelc Michal PhD. |
PFAS_Free - Feasibility study for the microbiological degradation of poly- and perfluoroalkyl
Štúdia uskutočniteľnosti mikrobiologickej degradácie poly- a perfluóralkylu
| Duration: | 1. 7. 2024 - 30. 6. 2027 |
| Evidence number: | APVV-23-0382 |
| Program: | APVV |
| Project leader: | Ing. Taveri Gianmarco PhD. |
Biopolymers for the development of innovative treatments and energy self-sufficiency.
Využitie biopolymérov pre vývoj inovatívnych liečebných postupov a energetickej sebestačnosti
| Duration: | 1. 1. 2023 - 31. 12. 2025 |
| Evidence number: | 2/0137/23 |
| Program: | VEGA |
| Project leader: | Mgr. Mosnáček Jaroslav DrSc. |
NanoCAre - Nanomedical approach to fight pancreatic cancer via targeting tumorassociated carbonic anhydrase IX
Využitie nanomedicíny v boji proti rakovine pankreasu prostredníctvom zacielenia nádorovo-asociovanej karbonickej anhydrázy IX.
| Duration: | 1. 7. 2021 - 30. 6. 2025 |
| Evidence number: | APVV-20-0485 |
| Program: | APVV |
| Project leader: | Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | Pancreatic cancer is a lethal disease with a rising incidence and mortality and it is the fourth leading cause of cancer-related deaths in Europe. The median survival time of pancreatic cancer is 4-6 months after diagnosis, the lowest survival rate of all cancers. Only 20% of diagnosed cases are operable. Photothermal therapy (PTT) has the potential to become a new frontrunner in the fight against pancreatic cancer. This cutting-edge biomedical application relies on the rapid heating of the plasmonic nanoparticles induced by laser light absorption, followed by an increase in the ambient temperature around the nanoparticles. The effect of the localized surface plasmon resonance (LSPR) can be observed only in a special class of nanoparticles. Photothermal therapy results in selective hyperthermia and irreversible damage of the tumor while avoiding damage to healthy tissue. However, the delivery efficiency of plasmonic nanoparticles is often insufficient. It can be increased by a dedicated functionalization of the plasmonic nanoparticles with ligands (antibodies) that selectively recognize the cancer cells. One of the main aims of the proposed project is to increase the delivery efficiency of the plasmonic nanoparticles for PTT by functionalization with antibodies that selectively recognize the tumor in the body. A promising target for functionalized nanoparticles is carbonic anhydrase IX, a hypoxia biomarker associated with an aggressive phenotype. CA IX is expressed in many types of tumors, while being absent from adjacent healthy tissue, making it an ideal highly specific candidate for anti-cancer therapy target. CAIX is abundantly expressed on the surface of pancreatic cancer cells where it correlates with a poor patient outcome. Targeting pancreatic cancer via nanomaterials-based approach combined with anti-CAIX antibody ensures highly selective application of PTT with potential benefits in the clinical environment. |
DITIMA - Development of unique TiMg composite dental implant
Vývoj unikátneho TiMg kompozitného zubného implantátu
| Duration: | 1. 7. 2021 - 30. 6. 2025 |
| Evidence number: | APVV-20-0417 |
| Program: | APVV |
| Project leader: | Mgr. Švastová Eliška PhD. |
| Annotation: | Dental implants (Dis) become more affordable and sought solution across a globe, the will be in a place for longer periods and a need for maintenance will decrease. Titanium (Ti) and Ti alloys are the most widely utilized materials for production of DI. Even though Ti-based DI are used with a high success rate, two major issues have remained insufficiently resolved: the stress-shielding effect and their insufficient surface bioactivity. That pushes competition, progress and R&D in the related area further and brings a need for novel solutions, approaches and material concepts. The main aim of proposed project is a development of an innovative endosseous biomedical DI fabricated from the unique partially biodegradable Ti - magnesium (Mg) composite material. New DI will minimize the main drawbacks of the contemporary DI, while it maintains the mechanical performance and fatigue endurance of Ti-based references. An advantageous combination of the mechanical, fatigue, corrosion and biological properties of developed DI is owing to a special DI`s design, which reflects and takes advantage of Ti17Mg, the material it will be manufactured from. Ti17Mg is the experimental powder metallurgy material invented by project partners, which selectively exploits the advantages of both biometals. In the project a new DI will be designed and optimized, in order to reflect unique behavior and workability of Ti17Mg. Performance of DI will be assessed and optimized systematically in an environment, which simulates real-life conditions in a human body, including mechanical, fatigue and corrosion testing, and in-vitro and in-vivo biological evaluation using cell culture, small and large animal models. All assays will be carried out in accordance with related ISO specifications. It is anticipated that at the end of the project new innovative high value-added DI is available and pending for testing in a human body. Expectedly TRL 6 will be accomplished at the end of project. |
TESLOW - Towards Eco-sustainable Sodium-ion batteries for a LOW-cost technology
Základ k ekologicky udržateľným sodíkovo-iónovým batériám pre nízko nákladovú technológiu
| Duration: | 1. 7. 2024 - 30. 6. 2028 |
| Evidence number: | APVV-23-0474 |
| Program: | APVV |
| Project leader: | Ing. Taveri Gianmarco PhD. |
Projects total: 30