Centre of Experimental Medicine SAS
Identification of stress-induced alterations in the expression of NRF2 target genes in rat models of prehypertension
Name of the supervisor
RNDr. Iveta Bernátová, DrSc.
Faculty of Natural Sciences Comenius University
Chronic stress is an important factor involved in the etiology of non-communicable diseases, including high blood pressure. NRF2 is a transcription factor that regulates the expression of many genes, among them genes involved in the detoxication of reactive oxygen and nitrogen species, iron metabolism, glucose metabolism, inflammation, and others. The aim of the dissertation is to identify changes in the expression of selected target genes of the NRF2, which are induced by chronic stress in prehypertensive rats with and without hypertriglyceridemia, which could be a marker of increased risk of developing stress-induced hypertension.