Centre of Experimental Medicine SAS
Topic
A model of cardiometabolic diseases induced by a Western diet in prehypertensive rats
PhD. program
Animal physiology
Name of the supervisor
RNDr. Iveta Bernátová, DrSc.
Contact:
Receiving school
Faculty of Natural Sciences Comenius University
Annotation
The aim of this dissertation is to develop and characterize an experimental model of comorbid cardiometabolic diseases (hypertension, non-alcoholic fatty liver disease) induced by a Western diet (WD) in rats with a genetic predisposition to borderline hypertension (BHR). We will focus on changes in the transcription of the nuclear factor NRF2 (nuclear factor erythroid 2-related factor 2) and its target antioxidant, anti-inflammatory, and iron metabolism-regulating genes in selected tissues. We will also investigate whether the NRF2 activator dimethyl fumarate can prevent the development of these diseases induced by a Western diet.