Biomedical Research Center SAS
Targeted manipulation of viral glycoprotein properties to restore immunity
Name of the supervisor
Mgr. Ivana Nemčovičová, PhD.
Faculty of Science, Pavol Jozef Šafárik University in Košice
Viruses have evolved elegant mechanisms to evade detection by the host immune system. One of the evasion strategies that have been adopted by large DNA viruses is to encode homologues of endogenous molecules that have a crucial role in control of the immune response. The main thesis objective is to closely examine the molecular basis of immune recognition of clinically relevant glycoprotein encoded by human cytomegalovirus (HCMV). In this regard, we are planning a preparation, characterization, expression and purification of selected set of recombinant viral and human genes that are associated with cytotoxicity and viroprotectivity processes in the cell. The study of viral proteins could uncover the strategies of immune modulation that might have high therapeutic potential.