Institute of Molecular Biology
Mechanisms of cell division during Bacillus subtilis sporulation
Molecular Biology, Microbiology, Genetics, Biochemistry
Name of the supervisor
RNDr. Imrich Barák, DrSc.
Faculty of Natural Sciences
Probably one of the most controversial questions about the cell division of Bacillus subtilis, a rod-shaped bacterium, concerns the mechanism that ensures correct division septum placement – at mid-cell during vegetative growth but closer to one end during sporulation. In general, bacteria multiply by binary fission, in which the division septum forms almost exactly at the cell centre. We know even less about how the asymmetric septation site is determined during sporulation in B. subtilis. Questions related to regulation of asymmetric septum positioning are main focus of this proposed PhD study.