Centre of Biosciences SAS
Topic
Characterization of the new molecular mechanisms underlying the repression of gene expression in yeast
PhD. program
Genetics
Year of admission
2024
Name of the supervisor
Mgr. Martin Valachovič, PhD.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University in Bratislava
Annotation
Eukaryotic cells have evolved two mechanistically distinct pathways to repair DSBs during mitosis: non-homologous end joining (NHEJ) and homologous recombination (HR). Our latest research revealed that the mutants carrying deletions of genes involved in the HR pathway exhibited more than 500 significantly upregulated genes, enriched for transcripts from subtelomeric genes, LTR retrotransposons, and antisense transcripts. The aim of a PhD project will be to reveal the mechanisms underlying this new phenomenon.