Centre of Biosciences SAS
Topic
DNA methylation changes accompanying the development of multidrug resistance
PhD. program
Biochemistry
Year of admission
2024
Name of the supervisor
Mgr. Lucia Pavlíková, PhD.
Contact:
Receiving school
Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava
Annotation
The development of multidrug resistance (MDR), mediated by overexpression of ABC transporters, represents a difficult obstacle to overcome in cancer chemotherapy. The MDR phenotype is also accompanied by activation of other defense mechanisms that protect the cell from damage by cytostatic agents, even those that are not ABC transporter substrates. The origin of these mechanisms may be twofold. They may be directly related to the presence of ABC transporter in cells because of common mechanisms controlling their induction or they may have developed as a result of selection pressure of cystostatic drugs during treatment but independently of the induction of ABC transporter expression. It is changes in the methylation of promoter regions of genes whose modulation may be involved in the development of multidrug resistance that may be responsible for the wide variability in cellular responses to cytostatic-induced chemical stress and the frequently observed changes in the differentiation status of cells.