Institute of Neuroimmunology
Topic
Immunophenotyping of B- cells induced by vaccination: markers of immunity
PhD. program
Molecular biology
Year of admission
2024
Name of the supervisor
MVDr. Ľubica Fialová, PhD.
Contact:
Receiving school
Faculty of Natural Sciences Comenius University in Bratislava
Annotation
B cells play key role in immunity and are responsible for generation of antibodies. Following antigen stimulation, B cells differentiate into memory plasma cells and continually secrete antibodies. Memory plasma cells are critical component of long-term protection induced by vaccination or infection. The dynamics of antigen-specific memory B cells is not well understood and little is known about their longevity. Complex view on the dynamics and phenotype of antigen-specific B cells can help better understand of the generation of immune memory, duration of protection and determination of markers of immunity. In the project we will monitor the phenotype of antigen-specific B cells after vaccination. The results of this project may contribute to improving the design of current vaccines, including long-term immune memory.