Institute of Neuroimmunology
Topic
Identification of dysregulated signaling pathways in animal model of neurodegeneration
PhD. program
Molecular biology
Year of admission
2024
Name of the supervisor
RNDr. Martin Čente, PhD.
Contact:
Receiving school
Faculty of Natural Sciences Comenius University in Bratislava
Annotation
Neurodegeneration process of tauopathies is characterized by the presence of neurofibrillary tangles composed of pathological forms of tau protein. Accumulation of these insoluble protein aggregates is accompanied by changes of homeostasis and dysregulation of intracellular signaling. Since, the exact molecular pathways involved in this process were not completely clarified to date, using transcriptomic and proteomic approach we will analyze consequences and accompanied phenomena of truncated tau protein toxicity in animal model of neurofibrillary degeneration. The research is oriented to detailed characterization of expression changes for genes and miRNAs involved in wide range of signaling pathways with respect to tau protein pathology. We suppose that our analysis in brain tissue and peripheral blood will contribute to elucidation of dysregulated molecular mechanisms reflecting degeneration of central nervous system.