Institute of Neuroimmunology
Topic
Study of the impact of heatstroke on the function of CNS cells
PhD. program
Medical neurosciences
Year of admission
2024
Name of the supervisor
PharmDr. Andrej Kováč, PhD.
Contact:
Receiving school
Faculty of Medicine Comenius University in Bratislava
Annotation
Global warming elevates the occurrence of heat-related illnesses, including heat stroke. Heat stroke is the most severe heat-related condition, marked by an elevated core body temperature, accompanied by CNS dysfunction. This project aims to modernize and enhance the diagnostics of heat-related illnesses in Slovakia and facilitate the translation of findings into clinical practice. To achieve this, metabolomics will be employed to investigate potential biomarkers, offering fresh insights into the pathogenic mechanisms of neurological complications arising from heatstroke. Metabolites identified as biomarkers with clinical relevance hold the promise of improving diagnosis, prognosis, drug screening, and treatment of heat-related illnesses. This study will focus on the identification of metabolites linked to early organ injury, long-term post-heatstroke health outcomes, and metabolite responses to pharmacological interventions. The identified markers will undergo validation processes to ensure their suitability for integration into clinical practice, thus contributing to effective management and prevention of heat-related illnesses.