Centre of Experimental Medicine SAS
Topic
Therapeutic potential of natural antioxidants 7,8-dihydroxyflavone and Naringin in animal model of depression
PhD. program
Normal and pathological physiology
Name of the supervisor
RNDr. Stanislava Vranková, PhD.
Contact:
Receiving school
Faculty of Medicine Comenius University
Annotation
Depression is the most common mental disorder in the world. Commonly used antidepressants exert their effect only after several weeks of continuous treatment. In addition, their serious side effects in one-third of patients call for urgent action. With the rapid increase of depressive patients worldwide, seeking novel molecular targets and therapeutic strategies is important for antidepressant therapy. Compounds capable of inducing rapid structural and functional rearrangement of neuronal networks are particularly attractive. Several of these psychoplastogens are naturally occurring antioxidants, such as 7,8-dihydroxyflavone (7,8-DHF) and Naringin. We will explore the effects of 7,8-DHF and Naringin, as well as their combination, on the development of depressive-like symptoms in animal model of depression.