Centre of Experimental Medicine SAS
Topic
Modulatory Effects of Polyphenolic and Indole-like Compounds on Pancreatic Beta Cells Under Glucose Toxicity Conditions
PhD. program
Biochemistry
Name of the supervisor
RNDr. Jana Lomenová, PhD.
Contact:
Receiving school
Faculty of Natural Sciences Comenius University
Annotation
The doctoral thesis will aim to study the effect of polyphenolic and indole-like substances on pancreatic beta cell lines under experimental conditions associated with elevated glucose levels, such as diabetes mellitus. Diabetic conditions will be induced by cytokines, free fatty acids (palmitate), and glucose metabolites (methylglyoxal). Subsequently, the modulatory effect of polyphenolic and indolic substances will be investigated to prevent impairment induced by the aforementioned inducers.