Institute of Molecular Biology
Topic
How phosphorylation of the proteases and heat shock proteins influence the mitochondrial functions
PhD. program
Genetics, Molecular Biology, Biochemistry
Name of the supervisor
RNDr. Vladimír Pevala, PhD.
Contact:
Receiving school
Commenius University, Faculty of Natural Sciences
Annotation
An important active player in the regulation of mitochondrial homeostasis are ATP dependent proteases, peptidases and mitochondrial stress proteins that are predicted to regulate each other. The aim of this work will be to explain the function of proteases and mitochondrial stress proteins in regulating the dynamics of the mitochondrial nucleoid. The work will focus on the expression, purification, preparation of human mitochondrial proteases and stress proteins and their post-translationally modified versions in order to determine their structure and function to help understand their role in regulating mitochondrial functions with potential in cancer treatment.