Amphiphilic polymers based on 2-oxazolines as antiviral drug delivery systems.
Name of the supervisor
Mgr. Juraj Kronek, PhD.
Faculty of Chemical and Food Technology STU
Block and gradient amphiphilic copolymers represent polymer materials with hierarchical structure and they are able to self-assemble in aqueous solutions. Gradient copolymers can form in contrast to block copolymers nanoparticles with amorphous phase of the hydrophobic core what is related to higher stability of the prepared particles and thus better encapsulation of a drug. For the preparation of gradient copolymers, new types of 2-oxazoline monomers containing substituted or condensed aromatic unit will be used. Here we will investigate the effect of aromatic ring type on the non-covalent interactions with the drugs, colloidal stability, encapsulation capacity and in vitro internalization of the formed nanoparticles. Drug release profile will be studied in vitro and ex vivo.