Biomedical Research Center SAS
Topic
Study of dynamics and morphology of cellular structures in experimental models of Wolfram syndrome
PhD. program
animal physiology
Name of the supervisor
RNDr. Michal Cagalinec, PhD.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University
Annotation
Wolfram syndrome (WS) is a serious hereditary disorder originally classified as mitochondrial, but it was later shown that WS develops as a result of mutations in Wolframin 1 protein, located in the endoplasmic reticulum (ER) membrane. Why does a protein located in ER so strongly affect mitochondria? In the search for answers to these questions, we will use biochemical methods, molecular biology methods, immunofluorescence as well as electron microscopy. With the help of these methods, we determine the morphological and functional relationships of cell organelles and their proteins in experimental models of WS.