Biomedical Research Center SAS
Topic
The role of inhibitory neurotransmission in neurodevelopmental diseases
PhD. program
animal physiology
Name of the supervisor
doc. RNDr. Ján Bakoš, PhD.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University
Annotation
Gamma-aminobutyric acid (GABA) is one of the most important inhibitory neurotransmitters in the central nervous system. Increasing number of studies indicate that the formation of GABA-producing neurons, the differentiation of their subtypes, as well as the action of GABA on the postsynaptic membrane are important factors in brain development. The aim of the PhD project is to study markers and changes in inhibitory neurotransmission in brain areas relevant for the development of social behavior. The project includes use of transgenic mouse model of autism, immunostaining for postsynaptic proteins and behavioral evaluation for a comprehensive understanding of the mechanisms leading to neurodevelopmental diseases.