Biomedical Research Center SAS
Topic
Study of the effect of pathogenic mutations on the activity of the ryanodine receptor using allosteric models of channel gating
PhD. program
biophysics
Name of the supervisor
Ing. Miloslav Karhánek, PhD.
Contact:
Receiving school
Faculty of Science, Pavol Jozef Šafárik University
Annotation
Ryanodine receptors (RyR) are ion channels responsible for control of excitation-contraction coupling in skeletal (RyR1) as well as cardiac muscle (RyR2). Pathogenic RyR mutations lead to dysregulation of channel activity by Ca2+ and Mg2+ ions, causing arrhythmias and malignant hyperthermia. The aim is to elucidate the effect of selected pathogenic mutations on the regulation of RyR activity by Ca2+ and Mg2+ ions, using allosteric models of channel gating.
Methods: programming in C++; model optimization; Markov processes, reaction-diffusion equations
Methods: programming in C++; model optimization; Markov processes, reaction-diffusion equations