Institute of Experimental Physics
Topic
Nanomaterials for medical application – functionalization and physicochemical characterization of magnetic nanoparticles based on iron oxides
PhD. program
Advanced materials
Name of the supervisor
Ing. Martina Koneracká, CSc.
Contact:
Receiving school
Faculty of Science, P.J. Safarik University
Annotation
The aim of the work will be to manage the technology of preparation of magnetic colloidal suspensions based on iron oxide nanoparticles, to functionalize the surface of nanoparticles with biologically active substances in order to minimize their toxicity and ensure their biocompatibility and stability in biological media. Further, to characterize the prepared magnetic nanomaterials in terms of size distribution, morphology, structure, stability, surface and magnetic properties using various techniques. At the same time, their effect on contrast in magnetic resonance imaging (MRI) will be investigated. The amount of heat generated after the application of magnetic hyperthermia will be also measured on the prepared samples, depending on the intensity and frequency of the alternating magnetic field. The results of the study can be used for targeted drug delivery, for the detection of tumour cells, which in combination with hyperthermia and MRI can represent a significant advance in the detection and treatment of cancer.