Institute of Experimental Physics
Topic
Intrinsically disordered proteins in Alzheimer´s disease and other amyloidoses
PhD. program
Biophysics
Name of the supervisor
doc. RNDr. Zuzana Gažová, DrSc.
Contact:
Receiving school
Faculty of Science, P.J. Safarik University
Annotation
The prevalence of neurodegenerative conditions like Alzheimer's disease (AD) continues to rise with aging of human population. These diseases often result from impaired protein synthesis, leading to the accumulation of misfolded proteins in the brain. The proteins aggregate into amyloid structures rich in β-sheets throughout various brain regions. Despite their widespread impact, the precise mechanisms driving amyloid formation remain poorly understood, and effective treatments remain elusive. This research endeavors to elucidate the mechanisms underpinning amyloid aggregation in intrinsically disordered proteins (IDPs) associated with AD and other amyloid-related diseases. Employing biophysical methodologies, we aim to study the pathways involved in amyloid aggregate formation. Furthermore, we will systematically explore potential interaction partners to counteract amyloid aggregation of IDPs, offering promising therapeutic intervention in these debilitating diseases.