Centre of Experimental Medicine SAS
Effects of mesenchymal stem cells and HMGB1 inhibitor on on cardiovascular system after experimentally induced myocardial infarction in hypertension
Normal and pathological physiology
Name of the supervisor
RNDr. Martina Cebová, PhD.
Faculty of Medicine Comenius University
Hypertension is an important risk factor for the development of atherosclerosis and heart failure. In animal models of hypertension, changes in cardiac protein expression occur before the development of atherosclerosis, a risk factor for myocardial infarction. The aim of the study will be to clarify the significance of the nitric oxide signaling pathway in the pathophysiology of myocardial infarction and ischemia/reperfusion injury. The experiments are designed to define the early molecular and morphological changes that are caused by either the application of stem cells or glycyrrhizin, an HMGB-1 inhibitor, given after myocardial infarction and contribute to the improvement of myocardial function and structure.