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PhD. Topics

Institute of Experimental Physics

Misfolding proteins in amyloid diseases and their prevention/therapy
PhD. program
Name of the supervisor
doc. RNDr. Zuzana Gažová, DrSc.
Receiving school
Faculty of Science, P.J. Safarik University
As our life expectancy increases, so does the likelihood of diseases such as Alzheimer's disease or diabetes. One of the causes of these amyloid diseases is an impaired synthesis of functional protein molecules and insufficient degradation of non-functional, misfolded protein molecules. As a result, misfolded proteins accumulate in the form of amyloid aggregates with a high content of β-sheets in various human body tissues. There is currently a lack of detailed knowledge of the causes of amyloid formation and no treatment for any known amyloid diseases. We will use modern biophysical methods to study the mechanisms of amyloid aggregates formation of globular and intrinsically disordered proteins associated with diseases such as AD, diabetes or systemic lysozyme amyloidosis. At the same time, we will focus on the systematic search for interaction partners to prevent these diseases, respectively treat them.