Biomedical Research Center SAS
Evaluation of immune checkpoints in B cell malignancies
Name of the supervisor
RNDr. Dana Cholujová, PhD.
Faculty of Natural Sciences, Comenius University in Bratislava
Malignant lymphomas are mostly incurable blood cancers affecting different white blood cells formed in lymphoid structures, including the lymph nodes, spleen, and bone marrow. They have different origin in B cell development with different biological properties and clinical aggressiveness. In this study, we will analyze the immunological mechanisms “immune checkpoints” that can be targeted in malignant lymphoma. The better understanding of pathogenesis of B-cell malignancies will lead to new therapeutic strategies directed against tumor and immune cells to completely eradicate tumor in individual patient.