The list of national projects SAS
Institute of Measurement Science
Ion exchange strengthened aluminosilicate glass/glass-ceramics with additional functionalities
Aluminosilikátové sklo/sklokeramika spevnené iónovou výmenou s ďalšími funkciami
| Duration: |
1.1.2021 - 31.12.2024 |
| Program: |
VEGA |
| Project leader: |
Ing. Majerová Melinda PhD. |
| Annotation: | The project aims to improve the mechanical properties of glass-ceramics by ion exchange technology known mainly in connection with the strengthening of common oxide glasses (eg Gorilla glass used in mobile phones). Mechanical stresses on the surface of ion exchange strengthened ceramics doped with suitable additives will allow modification of other properties, such as optical, due to changes in the composition of the glass matrix (chemical environment of optically active additives) or deformation of the coordination polyhedra of optically active ions. The use of silver ions in ion exchange will make it possible to create glass / glass-ceramic surfaces with high durability and antibacterial properties. |
Automatic data evaluation tool from the longitudinal quantitative MRI studies of articular cartilage
Automatický softvérový nástroj na výhodnocovanie kvantitatívnych MRI štúdií artikulárných chrupaviek v čase
| Duration: |
1.7.2022 - 30.6.2026 |
| Program: |
SRDA |
| Project leader: |
Ing. Dr. Szomolányi Pavol (PhD.) |
| Annotation: | The aim of the project is to design a comprehensive tool for automatic evaluation of human articular cartilage data from quantitative MRI. Data obtained from the Osteoarthritis Initiative database, and measured at Institute of Measurement Science and Medical University of Vienna will be segmented using an automated segmentation tool based on convolutional neural networks. The annotated data will then be registered on quantitative MRI data that will be available from the database (T2 and T1rho mapping, gagCEST, sodium MR) using automated or semiautomated tools developed within this project. The data obtained will be evaluated at multiple time points according to MR measurements that will be available. In addition to quantitative MR data, this will include volumetric data, cartilage thickness, and texture analysis of quantitative maps. Patient evaluation will be based on risk factor groups (transverse ligament rupture, meniscus rupture and menisectomy). The expected number of patients is approximately 4000 divided into individual groups in the ratio 40/30/30. The output of the project will be a compiled version of an automatic cartilage evaluation tool that will be available in a public source (such as website of Institute of Measurement). |
CT modeling and morphological analysis of the postcranial region of extinct and current lizards and their relatedness based on new morphological data
CT modelovanie a morfologická analýza postkraniálneho regiónu vyhynutých i súčasných jašterov a ich príbuznosť založená na nových morfologických dátach
| Duration: |
1.1.2021 - 31.12.2023 |
| Program: |
VEGA |
| Project leader: |
RNDr. Hain Miroslav PhD. |
| Annotation: | The cranio-cervical and brachial regions, together with the limbs, are not only really important, but all their parts
form well-described modular units that can provide a model system for assessing interaction
their individual functions, their development and phylogenetic history on the morphology of adults. Their understanding with
using a new approach that integrates detailed morphological analysis with modern computer methods
(biomechanical simulations, 3D morphometry and iodine enhanced CT imaging of soft tissues, phylogenetic
analysis) is therefore crucial. Due to the different lifestyles and the extreme range of sizes and morphologies
body, squamates provide an ideal model group for detailed integrated cranio-cervical studies,
more or less complete loss or reduction of limbs and braids allow to examine the relationship between anatomy,
functional morphology, phylogenetic position, lifestyle and development. The study will focus on today's,
but also fossil lizards (eg from the Messel locality in Germany). |
Trustworthy human–robot and therapist–patient interaction in virtual reality
Dôveryhodná interakcia človek–robot a terapeut–pacient vo virtuálnej realite
| Duration: |
1.7.2022 - 30.6.2026 |
| Program: |
SRDA |
| Project leader: |
Ing. Mgr. Rosipal Roman DrSc. |
| Annotation: | We aim to study specific forms of social interaction using state-of-the-art technology - virtual reality (VR) which is
motivated by its known benefits. The project has two main parts, human–robot interaction (HRI) and therapist–
patient interaction (TPI). The interactions are enabled using head-mounted displays and controllers allowing the
human to act in VR. We propose two research avenues going beyond the state-of-the-art in respective contexts. In
HRI, we will develop scenarios allowing the humanoid robot to learn, understand and imitate human motor actions
using flexible feedback. Next, we develop scenarios for testing and validating human trust in robot behavior based
on multimodal signals. We will also investigate physical interaction with a humanoid robot NICO. In TPI with stroke
patients, we develop a series of VR-based occupational therapy procedures for motor and cognitive impairment
neurorehabilitation using an active and passive brain-computer interface, and we will validate these procedures.
We expect observations from HRI experiments to be exploited in TPI. The proposed project is highly
multidisciplinary, combining knowledge and research methods from psychology, social cognition, robotics, machine
learning and neuroscience. We expect to identify features and mechanisms leading to trustworthy processes with a
human in the loop, as a precondition of success, be it a collaborative task or treatment in VR. |
Efficient computation methods for nanoscale material characterization
Efektívne výpočtové metódy pre charakterizáciu materiálov v nano mierke
| Duration: |
1.7.2022 - 30.6.2025 |
| Program: |
SRDA |
| Project leader: |
Doc. RNDr. Witkovský Viktor CSc. |
| Annotation: | The aim of the project is to design and implement effective calculation methods for evaluating the results of
measuring the mechanical properties of materials at the nanoscale using instrumented indentation methods (IIT)
and atomic force microscopy (AFM). Both of these methods are able to provide highly localized information on the
mechanical properties of the material, such as Young's modulus of elasticity (both methods), hardness (IIT
method), or point-to-surface adhesion (AFM method). The principle is the analysis of the recording of the position
of the measuring tip and the force interaction between the tip and the sample surface. The determination of the
resulting values on the basis of data recorded by the instrument in both of these methods is based on non-trivial
mathematical-statistical methods and calculation procedures working with data subjected to relatively high
uncertainty or random noise, where it is also necessary to quantify the uncertainty of the measurement result. Both
of these methods work with data of a similar nature, but each has certain specifics. The results obtained for IIT can
thus serve as a reference for AFM. The project partners are the Czech Metrology Ins titute (CMI is the national
metrology institute of the Czech Republic with top infrastructure in the field), the Institute of Measurement Science
SAS (IMS SAS), and the Mathematical Institute SAS (MI SAS), which are academic institutions with extensive
experience in basic research and applications of mathematics statistics in the field of measurement and metrology.
This combination of partners brings a natural synergy and a combination of the necessary competencies for this |
Smart deep brain stimulation as a treatment strategy in treatment-resistant depression
Inteligentná hĺbková mozgová stimulácia ako inovatívna stratégia pre liečbu mozgových porúch
| Duration: |
1.1.2022 - 31.12.2025 |
| Program: |
VEGA |
| Project leader: |
Ing. Mgr. Rosipal Roman DrSc. |
| Annotation: | Impaired connectivity between different brain areas underlines the pathophysiology of multiple brain disorders. It is possible that impaired connectivity between the prefrontal cortex and ventral pallidum is involved in depression. Smart deep brain simulation, combining real-time detection of the neuronal activity in the prefrontal cortex with the stimulation of the ventral tegmental area might be thus effective in depression. We aim to examine the cortico-tegmental connectivity and to test the antidepressant-like effectiveness of the smart deep brain stimulation in an animal model of depression. |
Causal analysis of measured signals and time series
Kauzálna analýza nameraných signálov a časových radov
| Duration: |
1.1.2022 - 31.12.2025 |
| Program: |
VEGA |
| Project leader: |
RNDr. Krakovská Anna CSc. |
| Annotation: | The project is focused on the causal analysis of measured time series and signals. It builds on the previous results of the team, concerning the generalization of the Granger test and the design of new tests in the reconstructed state spaces. The aim of the project is the development of new methods for bivariate and multidimensional causal analysis. We will see the investigated time series and signals as one-dimensional manifestations of complex systems or subsystems. We will also extend the detection of causality to multivariate cases - dynamic networks with nodes characterized by time series. Such complex networks are common in the real world. Biomedical applications are among the best known. Brain activity, determined by multichannel electroencephalographic signals, is a crucial example. We want to help show that causality research is currently at a stage that allows for ambitious goals in the study of effective connectivity (i.e., directed interactions, not structural or functional links) in the brain. |
Personalized Optimisation of Cardiac Resynchronization Therapy in Heart Failure Based on Multiple Lead ECG Measurement
Personalizovaná optimalizácia resynchronizačnej liečby srdcového zlyhávania na základe mnohozvodového merania EKG
| Duration: |
1.7.2020 - 30.6.2023 |
| Program: |
SRDA |
| Project leader: |
Doc. Ing. Tyšler Milan CSc. |
| Annotation: | Cardiac resynchronization therapy (CRT) is currently the most advanced therapeutic method for treatment of patients with failing heart. The essential criteria for patient indication for CRT are based on standard 12-lead ECG and echocardiographic measurements and include ECG pattern of left bundle branch block, prolongation of the QRS time interval, and left ventricular ejection fraction less than 35%. Despite most patients have a great benefit from the CRT, still 20-40% of patients do not profit from the therapy. On the other side, there is a considerable number of positive responders among patients not fulfilling the criteria. Therefore, there is a great effort to increase the success rate of the intervention and to find better criteria for its application.
Current research shows that surface ECG maps recorded by a large number of electrodes, ECG imaging solving the inverse problem of electrocardiology and reconstructing the electrical activity of the heart, or combination of ECG imaging with computed tomography to identify structural damage of the myocardium have potential for more reliable detection of the electrical dyssynchrony and for suggesting optimal electrode placement and their timing.
The main objective of the project is the research of methods for personalized optimization of the CRT therapy based on multi-lead surface ECG measurement and their verification on simulated data and data from real patients. The partial aims include:
• finding such body surface potential maps parameters that could serve as suitable indicators of the electrical dyssynchrony of ventricles,
• design of an inverse method for noninvasive localization of the latest activated areas in the ventricles and their use for placing the electrode in the left ventricle,
• simulation of failing heart activation to understand the undergoing processes and their reflection in surface ECG signals,
• development of a dedicated multi-lead ECG measuring system for personalized CRT optimization. |
Advanced mathematical and statistical methods for measurement and metrology
Pokročilé matematické a štatistické metódy pre meranie a metrológiu
| Duration: |
1.7.2022 - 31.12.2025 |
| Program: |
SRDA |
| Project leader: |
Doc. RNDr. Witkovský Viktor CSc. |
| Annotation: | Mathematical models and statistical methods for analysing measurement data, including the correct determination of measurement uncertainty, are key to expressing the reliability of measurements, which is a prerequisite for progress in science, industry, health, the environment and society in general. The aim of the project is to build on traditional metrological approaches and develop new alternative mathematical and statistical methods for modelling and analysing measurement data for technical and biomedical applications. The originality of the project lies in the application of modern mathematical methods for modelling and detecting dependence and causality, as well as statistical models, methods and algorithms for determining measurement uncertainty using advanced probabilistic and computational methods based on the use of the characteristic function approach (CFA). In contrast to traditional approximation and simulation methods, the proposed methods allow working with complex and at the same time accurate probabilistic measurement models and analytical methods. Particular emphasis is placed on stochastic methods for combining information from different independent sources, on modelling dependence and causality in dynamic processes, on accurate methods for determining the probability distribution of values that can be reasonably attributed to the measured quantity based on a combination of measurement results and expert knowledge, and on the development of methods for comparative calibration, including the probabilistic representation of measurement results with a calibrated instrument. An important part of the project is the development of advanced numerical methods and efficient algorithms for calculating complex probability distributions by combining and inverting characteristic functions. These methods are widely applicable in various fields of measurement and metrology. In this project they are applied to the calibration of temperature and pressure sensors. |
Probability distributions and their applications in modelling and testing
Rozdelenia pravdepodobnosti a ich aplikácie v modelovaní a testovaní
| Duration: |
1.1.2021 - 31.12.2023 |
| Program: |
VEGA |
| Project leader: |
Doc. RNDr. Witkovský Viktor CSc. |
| Annotation: | The project is focused on the research of complex problems related to probability distributions and their use in mathematical modeling and tests of statistical hypotheses, where it is necessary to know the distributions of test statistics. A new broad family of probability distributions will be investigated. Many commonly used distributions
are special cases of this family. New approaches to multivariate statistical problems will be developed (an error-in-variables linear model, nonparametric statistical inference about several populations, nonparametric independence tests, detection of causality). A new apparatus of mathematical statistics will be applied to mathematical models in metrology, linguistics, demography, and insurance mathematics. |
SQUID magnetometry of nano- and microparticles, nanocolloids and nanostructures in new applications in the field of biomedicine and materials research associated with the development of new measurement methods and procedures
SQUID magnetometria nano-a mikročastíc, nanokoloidov a nanoštruktúr v nových aplikáciach v oblasti biomedicíny a materiálového výskumu spojených s rozvojom nových meracích metód a postupov
| Duration: |
1.1.2021 - 31.12.2024 |
| Program: |
VEGA |
| Project leader: |
Ing. Maňka Ján CSc. |
| Annotation: | The theme of the project is the development of magnetic measurement methods and methodologies for
biomedicine and materials research. Its aim is to contribute to a better understanding of the following: impact of stress on iron metabolism at the systemic and cellular levels; magnetic properties of metal proteins such as transferrin, haemoglobin, and ferritin; thermal and photoluminescent properties of aluminous glasses doped with rare earth elements and transition elements; magnetic properties of high-entropy alloys, and colloids of the high-entropy alloys nanoparticles in ionic liquids - actors with a high application impact on the development of new measurement methods, instrumentation and a new generation of ecological industrial applications. The interdisciplinary character of the project is given by the studied samples and research themes. |
Role of nuclear factor NRF2-mediated signalling in iron metabolism regulation during stress
Úloha signalizácie sprostredkovanej jadrovým faktorom NRF2 v regulácii metabolizmu železa počas stresu
| Duration: |
1.1.2021 - 31.12.2024 |
| Program: |
VEGA |
| Project leader: |
Mgr. Škrátek Martin PhD. |
| Annotation: | Stress is considered to be an etiological factor associated with the development of various chronic
non-communicable diseases. Stress may also alter iron metabolism. Nuclear factor erythroid 2-related factor 2
(NRF2)-regulates several genes involved in iron metabolism. Despite the accelerating information on the roles of NRF2, less is known about the NRF2 signalling in iron metabolism in conditions of stress. Thus, the aim of this project is to investigate the role of NRF2 signalling in iron metabolism in conditions of acute and chronic stress in rats with genetic predisposition to hypertension. In addition, the effects of pharmacological activation of NRF2 signalling and the distinct roles of inducible and endothelial nitric oxide synthases in iron metabolism in stress conditions will be investigated. Project will bring the original results about NO and NRF2-mediated regulation of iron metabolism and the involvement of altered iron metabolism in the development of cardiovascular and metabolic disorders. |
Investigation of biomedical effects of low frequency and pulsed electromagnetic fields
Výskum biomedicínskych účinkov nízkofrekvenčných a pulzných elektromagnetických polí
| Duration: |
1.1.2022 - 31.12.2024 |
| Program: |
VEGA |
| Project leader: |
Mgr. Teplan Michal PhD. |
| Annotation: | Although there is a persisting interest in both adverse and beneficial biological effects of electromagnetic fields
(EMF), the unambiguous explanation of electromagnetic field influence on living structures is still lacking. For the
impact of low-frequency magnetic field (LF MF)
experimental platform with monitoring of the cell growth curve based on impedance spectroscopy will test possible inhibition or stimulation dependent on the frequency and magnetic flux parameters. Effects of pulsed electric field (PEF) will be monitored by biological autoluminescence (BAL). Complexity measures will be utilized for ultrafast current recordings during the PEF application. For quantification of direct effects of PEF on microtubules (MT) and evaluation of kinesin molecule movement, advanced image processing methods will be developed. The relevance of this research area lies in the
exploration of physical methods with possible contributions to diagnostics and therapy. |
Use of multi-lead ECG measurement and modeling of the electric field of the heart in non-invasive diagnostics and therapy of ventricular arrhythmias and heart failure
Využitie mnohozvodového merania EKG a modelovania elektrického poľa srdca pri neinvazívnej diagnostike a terapii komorových arytmií a zlyhávajúceho srdca
| Duration: |
1.1.2022 - 31.12.2024 |
| Program: |
VEGA |
| Project leader: |
Ing. Švehlíková Jana PhD. |
| Annotation: | The proposed project follows the previous one, in which we addressed signal processing and the inverse problem for the first clinical data from patients with arrhythmias. In the following period, we would like to expand the number of processed measurements to standardize the most suitable procedures for the processing of the measured signals. In addition to the diagnosis of premature ventricular contraction, we plan to process and evaluate multi-lead ECG signals of patients with heart failure and contribute to the methodology of evaluation of resynchronization therapy. We will also focus on the direct evaluation of the parameters of the measured potential maps. Personalized models of patients' hearts will be created and pathological processes will be simulated in them for a better understanding of the processes in the activation of heart ventricles. The simulated signals will be compared with clinical measurements. Within the international cooperation, we will compare our results with other inverse methods. |
Development and realisation of the standard of the static magnetic field based on a magnetic resonance
Vývoj a realizácia etalónu statického magnetického poľa na báze magnetickej rezonancie
| Duration: |
1.7.2020 - 30.6.2023 |
| Program: |
SRDA |
| Project leader: |
Ing. Andris Peter PhD. |
| Annotation: | The main aim of the present project is the design of advanced NMR measurement methods using the most advanced range of systems (with a low magnetic field 0.05, 0.2, Tesla) for the development and implementation of standard static magnetic field on a magnetic resonance. This standard would be the basic calibration device for
testing and calibration of the equipments that measure or generate magnetic field.
The use of it would be in the Slovak Republic.
Orientation research on:
- theoretical and experimental research methods for the measurement and mapping of static magnetic fields,
- standardizing the measurement metrology protocols,
- mapping the intensity of the vibrations generated by the measuring system and modeling of their layouts for
different measuring MRI sequences,
- spectral analysis of disturbing signals, identification of dominant frequencies and evaluation of their effects on the accuracy and stability of the magnetic standard. |
The total number of projects: 15
