The list of national projects SAS
Centre for Advanced Materials Application SAS
Carbon-silicon based composite anodes for Li-ion batteries.
Anódy pre Li-iónové batérie na báze uhlík-kremíkových kompozitov
Low energy synthesis of high performance NaSICON-like structured cathodes for rechargeable Sodium-Ion Batteries (SIBs)
Low energy synthesis of high performance NaSICON-like structured cathodes for rechargeable Sodium-Ion Batteries (SIBs)
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Návrh a optimalizácia biokonjugačných stratégii inovatívnych 2D fototermálnych nanomateriálov s tumor-navádzajúcimi peptidmi
Perovskite-based Films with Superior Passivation and Structure
Perovskitové vrstvy s vylepšenou pasiváciou a štruktúrou
Advanced Oxygen Tolerant Photochemically Induced Atom Transfer Radical Polymerization
Pokročilá fotochemicky indukovaná radikálová polymerizácia s prenosom atómu tolerantná k prítomnosti kyslíka
Towards lithium based batteries with improved lifetime
Pokročilé lítiové batérie s dlhou životnosťou
| Duration: |
1.7.2021 - 30.6.2025 |
| Program: |
SRDA |
| Project leader: |
Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | With the steadily increasing energy requirements of portable electronics and electromobility, conventional lithiumion
batteries are facing new challenges. In the proposed project, we aim to stabilize the capacity and lifetime of
lithium-ion batteries employing ultra-thin interfacial layers prepared by means of atomic layer deposition (ALD). The
primary functions of interfacial layers are: i) preventing the dissolution of the cathode materials into electrolyte and
ii) stabilizing the cathode morphology during lithiation and de-lithiation. Although the positive effect of ALD
fabricated interfacial layers has already been demonstrated, systematic studies are still missing. The main
bottleneck of such studies is the identification of appropriate feedback analytical techniques that enable real-time
and in-operando insights into the charging/discharging mechanisms on the nanoscale. The conventional
electrochemical characterization methods can only provide hints on the ongoing mechanism during degradation
processes. Here we propose to utilize in-operando small-angle and wide-angle X-ray scattering (SAXS, WAXS) to
track the morphology and phase changes that occur during the charging/discharging of lithium-ion batteries in realtime.
The main focus of this project is on the application of real-time SAXS/WAXS studies under laboratory
conditions. In these circumstances, extensive, systematic studies of various ALD interfacial layers can be
performed. |
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Porovnanie účinku nanosfér a nanobipyramíd zlata konjugovaných so silibinínom pri liečbe fibrózy pečene in vivo.
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Príprava a štúdium poréznej a neporéznej hliníkovej anódy pre účely zvýšenia výkonu primárnej Al-vzduch batérie.
Building a centre for advanced material application SAS
Vybudovanie centra pre využitie pokročilých materiálov SAV
Nanomedical approach to fight pancreatic cancer via targeting tumorassociated carbonic anhydrase IX
Využitie nanomedicíny v boji proti rakovine pankreasu prostredníctvom zacielenia nádorovo-asociovanej karbonickej anhydrázy IX.
| Duration: |
1.7.2021 - 30.6.2025 |
| Program: |
SRDA |
| Project leader: |
Dr. rer. nat. Šiffalovič Peter DrSc. |
| Annotation: | Pancreatic cancer is a lethal disease with a rising incidence and mortality and it is the fourth leading cause of
cancer-related deaths in Europe. The median survival time of pancreatic cancer is 4-6 months after diagnosis, the
lowest survival rate of all cancers. Only 20% of diagnosed cases are operable. Photothermal therapy (PTT) has the
potential to become a new frontrunner in the fight against pancreatic cancer. This cutting-edge biomedical
application relies on the rapid heating of the plasmonic nanoparticles induced by laser light absorption, followed by
an increase in the ambient temperature around the nanoparticles. The effect of the localized surface plasmon
resonance (LSPR) can be observed only in a special class of nanoparticles. Photothermal therapy results in
selective hyperthermia and irreversible damage of the tumor while avoiding damage to healthy tissue.
However, the delivery efficiency of plasmonic nanoparticles is often insufficient. It can be increased by a dedicated functionalization of the plasmonic nanoparticles with ligands (antibodies) that selectively recognize the cancer cells.
One of the main aims of the proposed project is to increase the delivery efficiency of the plasmonic nanoparticles
for PTT by functionalization with antibodies that selectively recognize the tumor in the body. A promising target for
functionalized nanoparticles is carbonic anhydrase IX, a hypoxia biomarker associated with an aggressive
phenotype. CA IX is expressed in many types of tumors, while being absent from adjacent healthy tissue, making it
an ideal highly specific candidate for anti-cancer therapy target. CAIX is abundantly expressed on the surface of
pancreatic cancer cells where it correlates with a poor patient outcome. Targeting pancreatic cancer via
nanomaterials-based approach combined with anti-CAIX antibody ensures highly selective application of PTT with
potential benefits in the clinical environment. |
Development of unique TiMg composite dental implant
Vývoj unikátneho TiMg kompozitného zubného implantátu
| Duration: |
1.7.2021 - 30.6.2025 |
| Program: |
SRDA |
| Project leader: |
Mgr. Švastová Eliška PhD. |
| Annotation: | Dental implants (Dis) become more affordable and sought solution across a globe, the will be in a place for longer
periods and a need for maintenance will decrease. Titanium (Ti) and Ti alloys are the most widely utilized materials
for production of DI. Even though Ti-based DI are used with a high success rate, two major issues have remained
insufficiently resolved: the stress-shielding effect and their insufficient surface bioactivity. That pushes competition,
progress and R&D in the related area further and brings a need for novel solutions, approaches and material
concepts.
The main aim of proposed project is a development of an innovative endosseous biomedical DI fabricated from the
unique partially biodegradable Ti - magnesium (Mg) composite material. New DI will minimize the main drawbacks
of the contemporary DI, while it maintains the mechanical performance and fatigue endurance of Ti-based
references. An advantageous combination of the mechanical, fatigue, corrosion and biological properties of
developed DI is owing to a special DI`s design, which reflects and takes advantage of Ti17Mg, the material it will be
manufactured from. Ti17Mg is the experimental powder metallurgy material invented by project partners, which selectively exploits the advantages of both biometals. In the project a new DI will be designed and optimized, in
order to reflect unique behavior and workability of Ti17Mg. Performance of DI will be assessed and optimized
systematically in an environment, which simulates real-life conditions in a human body, including mechanical,
fatigue and corrosion testing, and in-vitro and in-vivo biological evaluation using cell culture, small and large animal
models. All assays will be carried out in accordance with related ISO specifications.
It is anticipated that at the end of the project new innovative high value-added DI is available and pending for
testing in a human body. Expectedly TRL 6 will be accomplished at the end of project. |
The total number of projects: 11
