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The list of international projects SAS

Institute of Experimental Physics

Anti-amyloid activity of zeolite-based composites and analysis with real-time 3d super-resolution imaging

Anti-amyloidná aktivita kompozitov na báze zeolitov a analýza so zobrazovaním vo vysokom rozlíšení a v reálnom čase

Duration: 1.1.2022 - 31.12.2024
Program: JRP
Project leader: RNDr., Ing. Šipošová Katarína PhD.
Annotation:A common feature associated with most of neurodegenerative diseases, including Alzheimer’s disease is the formation of extended, β-sheet rich amyloid fibrils. Today, amyloid-related diseases are incurable and the treatment is only symptomatic without feasibility to stop or substantially delay the progressive consequences of the diseases. Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) jointly developed are expected to serve synergistic therapy approaches act as carriers for controlled drug delivery/release, imaging and local heating in biological systems, that can effectively decompose the amyloid-like fibrillar structures. The micro and mesopores of the natural zeolite can serve as containers for delivering various drugs to the target site to release. Magnetic CZ (MCZs) will improve drug delivery process, real-time monitoring of drug distribution surrounding a targeting side of tissue, as well as the subsequent effects of the therapeutics on the progression of diseases. In addition, fluorescent MCZs in combination with ultrasonic, magnetic or laser irradiation effects will provide hyperthermia and photoreaction to achieve both diagnosis and therapy. The Taiwanese research team has been deeply cultivated in temporal focusing multiphoton microscopy (TFMPM), which imaging frame rate can achieve up to a hundred hertz. We will use the deep learning method to improve the imaging frame rate for real-time biomedical analysis. Within this project, animal models (including genetic rodent models) will be utilized to develop a theranostic system for for inhibition and destruction of amyloid aggregates and super-resolution imaging of MZC induced amyloid aggregate inhibition/destruction effects by state-of-art temporally and spatially super-resolution 3D imaging technology.

Azobenzenes as potential Alzheimer's theranostic agents

Azobenzénové deriváty ako potenciálne terapeutiká pre Alzheimerovu chorobu

Duration: 1.1.2023 - 31.12.2024
Program: Mobility
Project leader: RNDr. Bednáriková Zuzana PhD.
Annotation:Amyloid fibrils of amyloid β (Aβ) peptides are a neuropathological feature of Alzheimer's disease (AD). AD is one of the world's fastest-growing neurological diseases with substantial economic and societal impact, but no cure is currently available. Therefore, the exploration of novel treatment approaches is in high demand. The project's main objective is to study the ability of azobenzene molecules to affect targets associated with the amyloid cascade of AD pathogenesis. The project will employ the lever-like potential of azobenzene molecules to dissociate fibrillar aggregates of Aβ peptides and inhibit the proteolytic activity of β-secretase. We will integrate in vitro, in silico, and cells workflow to find a possible alternative therapy against this devastating disease. Moreover, this collaborative research partnership will present an excellent opportunity for both teams' young members to learn new techniques in the well-equipped laboratories at the Polish and Slovak Academies of Sciences and gain new experience by working in an international scientific environment.

2Dimensional van der Waals Spin-Orbit Torque Technology

Dvojrozmerná van der Waalsovská spinovo-orbitálna torzná technológia

Duration: 1.12.2021 - 29.11.2024
Program: ERANET
Project leader: RNDr. Gmitra Martin PhD.
Annotation:Engineering two-dimensional (2D) material van der Waals heterostructures by combining the best of different functional constituents can offer a plethora of opportunities in nanoelectronics. Here, we propose to develop all-2D spintronics platforms for the next generation of information technology based on 2D magnetic and topological spin-orbit materials. These hybrid systems can provide a strong synergy between spintronics and 2D materials, with the goal of combining “the best of both worlds”. Such integration of spin-orbit physics and magnetism in 2D heterostructures will enable groundbreaking functionalities in all-2D spin-orbit torque (SOT) technologies for low-power and non-volatile memory and logic devices. We will exploit low crystal symmetry of layered spin-orbit materials (SOM), hosting novel spin textures for the realization of efficient charge-to-spin conversion (CSC) with a significant out-of-plane spin-orbit field contribution for SOT technologies. We will start with basic investigation of CSC by using potentiometric methods in non-local spin valve geometry with graphene heterostructures. These studies will provide information about the main driving mechanisms of the CSC phenomena, such as the spin Hall, Rashba-Edelstein, or other spin-momentum locking effects to generate a giant and tunable spin polarization. Magnetic 2D crystals, on the other hand, exhibit a wide range of magnetic ordering and, extraordinarily, have the potential to be controlled by purely electronic means. Here, we will investigate 2D magnets for SOT technologies exploiting their low-dimensionality, perpendicular magnetic anisotropy, and the possibility of electric field control. We will examine the dynamics of magnetic excitations, their anisotropies, and controllability by gates, the critical parameters influencing the magnetic switching speed. This project will integrate 2D magnets and SOMs with engineered interfaces to establish exceptionally efficient SOT switching functionalities in all-2D materials platforms. We aim to study the fundamentals of magnetization dynamics and SOT switching behavior of hybrid structures using electronic, magnetotransport, time and spatially resolved magneto-optics, ferromagnetic resonance and 2nd harmonic measurements. The potential of the novel functionalities in these heterostructures will arise from the interplay of exotic spin textures, magnetic phases, proximity-induced exchange and spin-orbit effects at the interfaces of the 2D materials. These effects will be further controlled by interface engineering with a graphene interlayer, twist angle between the layers, and with external parameters such as electric field and pressure. These functionalities will be complemented with voltage-controlled magnetization switching in ultrathin devices. Finally, we will utilize these engineered hybrid devices to demonstrate ultra-fast and low-power magnetization switching of 2D magnets, for a future generation of all-2D SOT technologies.

The ALICE experiment at the CERN LHC: Study of the strongly interacting matter under extreme conditions

Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach

Duration: 1.1.2022 - 31.12.2026
Program: CERN
Project leader: RNDr. Králik Ivan CSc.
Annotation:The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.

ATLAS experiment at LHC at CERN: deep-inelastic phenomenons and new physics at TEV energies

Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách

Duration: 1.1.2022 - 31.12.2026
Program: CERN
Project leader: RNDr. Stríženec Pavol CSc.

Innovative water-soluble phytomaterial inhibitors for Alzheimer’s and Parkinson’s disease prevention

Innovative water-soluble phytomaterial inhibitors for Alzheimer’s and Parkinson’s disease prevention

Duration: 1.10.2022 - 28.2.2025
Program: Horizon 2020
Project leader: MUDr. Musatov Andrey DrSc.

Self-heating magnetic nanoconstructs for theranostic applications

Magnetické nanoštruktúrne materiály schopné samozahrievania pre teranostické aplikácie

Duration: 1.7.2023 - 30.6.2025
Program: Bilateral - other
Project leader: RNDr. Kubovčíková Martina PhD.
Annotation:Cancer is still one of the leading causes of death worldwide, therefore significant research and innovation efforts are still needed to find new materials and methods for better cancer diagnosis and treatment. Magnetic nanoparticles (MNPs) appear to be a very promising material for use in many medical fields, such as in nanosurgery they can be used to kill tumor cells by increasing drug concentration in target cells in combination with hyperthermia as well. The presented project is focused on the development of new nanoconstructs labeled by radionuclide as a potential theranostic agent for radiotherapy and diagnostics. The first step to achieve the desired goal will be the synthesis of nanoconstructs consisting of self-heating magnetic nanoparticles coated with various biocompatible substances, which will exhibit the desired bioactivity as well. The prepared nanoconstructs will be studied by several physicochemical methods, and their stability and suitability for magnetic hyperthermia, i.e. the ability to produce heat in an alternating magnetic field, will be monitored. In the second step, nanoconstructs with the best properties will be radiolabeled with therapeutic 177Lu and diagnostic 99mTh radionuclides to prepare radioactive nanoconstructs for dual therapy and diagnosis. In the next step, in vitro toxicity testing of nanoconstructs labeled with radionuclides will be performed. The prepared magnetic magnetic nanostructured materials labeled with radionuclides will contribute to the improvement of diagnostics and therapy of cancer diseases. The project is based on a complex multidisciplinary approach, from physics, chemistry to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to achieve the project goals.

Non-globular proteins in the era of Machine Learning

Neglobulárne proteíny v ére strojového učenia

Duration: 25.10.2022 - 26.10.2026
Program: COST
Project leader: RNDr. Bednáriková Zuzana PhD.
Annotation:The ML4NGP Action aims to establish an interdisciplinary pan-European network to favour interplay between experiments and computation, fostering experimental frameworks designed to provide information to computational methods, and novel computational methods developed, trained and benchmarked with experimental data. ML4NGP will enhance the primary experimental data generation (WG1), promote integrative structural biology approaches (WG2), benchmark the state-of-the-art ML methods (WG3) and improve the functional characterization of NGPs (WG4). The Action will support its scientific objectives through policies that sustain free knowledge exchange, inclusiveness and training of young researchers who will lead future innovations in this field.

skQCI

skQCI

Duration: 1.1.2023 - 31.12.2025
Program: Digital Europe Programme
Project leader: RNDr. Skyba Peter DrSc.

Slovak contribution to ESA-JUICE mission: Development of Anti-Coincidence Module ACM for Particle Environment Package PEP

Slovenský príspevok k misii ESA-JUICE: Vývoj anti-koincidenčného modulu ACM pre časticový komplex PEP

Duration: 15.11.2018 - 31.12.2024
Program: European Space Agency (ESA)
Project leader: Ing. Baláž Ján PhD.,
Annotation:The ESA’s JUICE (JUpiter ICy moons Explorer) mission (http://sci.esa.int/juice) have to face to very hostile environment of Jovian radiation belts where the penetrating energetic electrons dominate. The Particle Environment Package (PEP) payload of this mission (http://sci.esa.int/juice/50073-science-payload ) was developed within a wide international collaboration led by Swedish Institute for Space Physics IRF in Kiruna. Due to limited available mass for efficient radiation shielding, the PEP payload will operate in rather unfavourable environment of penetrating energetic electrons that will affect the detection process inside the PEP/JDC (Jovian plasma Dynamics and Composition) sensor. To mitigate the unfavourable influence of the penetrating electron radiation to the plasma ions detection process, a concept of anti-coincidence module (ACM) has been identified within the PEP consortium. The project involves development of space-flight grade semiconductor solid state detector, the processing electronic board and a laboratory testing and calibration system RATEX-J (RAdiation Test EXperiment for JUICE). The JUICE probe has been successfully launched 14.4.2023 from space port Kourou. The PEP science suite has been successfuly commissioned in June 2023. The JUICE probe will be inserted into the orbit around Jupiter on 18. July 2031.

Structural, magnetic, and thermal investigations of novel functional materials

Structural, magnetic, and thermal investigations of novel functional materials

Duration: 1.1.2023 - 31.12.2024
Program: Mobility
Project leader: RNDr. Mihálik Matúš PhD.
Annotation:The object of the collaboration is investigation of the magnetic, structural and thermodynamic properties of new magnetic materials such as manganites, magnetic oxides and molecule-based magnets. Of particular importance is the full physical characterization of functional materials with light-, temperature- or pressure-controlled properties as well as magnetic molecular nanosystems. Collaboration in this area between the Institute of Nuclear Physics PAS and the Institute of Experimental Physics SAS lasts for over fifteen years. We have carried out common studies of several molecular magnets, workers of INP PAN take regularly part in the triennial CSMAG conference organized in Košice. We are in possession of different but complementary measurement instruments. Therefore, the continuation of the joint project, aimed at a more comprehensive description and understanding of properties of new magnetic materials, would be purposeful.

SUPERCONDUCTING NANODEVICES AND QUANTUM MATERIALS FOR COHERENT MANIPULATION

Supravodivé nanozariadenia a kvantové materiály pre koherentnú manipuláciu

Duration: 6.10.2022 - 5.10.2026
Program: COST
Project leader: prof., RNDr. Samuely Peter DrSc., akademik US Slovenska
Annotation:We propose a collaborative approach joining together efforts and groups all over Europe, structured around three pathways, (i) the synthesis and characterization of quantum materials with novel topological properties, (ii) the fabrication of sensors and devices exploiting novel superconducting functionalities and (iii) the generation and coherent manipulation of superconducting states that can create new opportunities in the superconducting quantum electronics. Using an open and inclusive approach that joins expertise and capabilities all over Europe, this project will structure collaborative efforts aiming at disruptive achievements in the field of superconductivity. The results will impact far beyond the development of new quantum solutions for computation, and include sectors such as health and energy.

Superconductivity in nitride thin films - materials for future quantum devices

Supravodivosť v tenkých filmoch nitridov - materiály pre budúce kvatové zariadenia

Duration: 1.11.2023 - 31.10.2024
Program: Other
Project leader: RNDr. Pristáš Gabriel PhD.
Annotation:The main aim of our common project is study superconductivity in nitride thin films. It was shown, that narrow NbN superconducting strips could be used for construction of ultrafast single photon detectors, which are expected to play important role in the secure quantum communications. Very recently, team from Montanuniversität Leoben succeeded in preparation of superconducting high entropy alloy (HEA) thin films and team from Slovak side preformed measurements of its superconducting properties. Preparation of nitride HEAs will be next step in effort to improve superconducting parameters of thin films for the purpose to be used in future quantum devices.

Study toward enhancing reliability and timeliness of Vigil mission predictions through Machine Learning

Štúdia smerujúca k zvýšeniu spoľahlivosti a včasnosti predikcií z dát misie Vigil pomocou strojového učenia

Duration: 1.10.2023 - 31.12.2025
Program: European Space Agency (ESA)
Project leader: RNDr. Mackovjak Šimon PhD.

Study of dynamics in interface region between space and Earth’s atmosphere

Štúdium dynamiky v oblasti rozhrania medzi vesmírom a atmosférou Zeme

Duration: 1.1.2023 - 31.12.2024
Program: Mobility
Project leader: RNDr. Mackovjak Šimon PhD.

Exploring correlated and topological phases in layered van der Waals quantum materials

Výskum korelovaných a topologických fáz vo van der Waalsovských materiáloch

Duration: 1.1.2023 - 31.12.2024
Program: Mobility
Project leader: Mgr. Szabó Pavol CSc.
Annotation:The project aims to explore novel quantum physics in heterostructures made of 2D materials focusing on emergent quantum phenomena induced by the spin-orbit coupling and its interplay with magnetism, topology, and superconductivity. We propose a study of van der Waals (vdW) heterostructures made of few-layer thin superconductors and ferromagnet and topological materials in order to study proximity effects on topologically induced superconductivity. The objective of the research is to build technological knowhow of sample preparation made of 2D materials, performing scanning tunneling microscopy and transport experiments which will be complemented by the state-of-the-art density functional theory calculations and tight-binding modeling of electronic structure to study quasiparticle interferences and transport properties.

Research on bulk superconductors

Výskum masívnych supravodičov

Duration: 1.5.2018 - 31.12.2026
Program: Other
Project leader: Ing. Diko Pavel DrSc., akademik US Slovenska
Annotation:The agreement on cooperation between IEP SAS and CAN Superconductorsis focused on research od REBCO bulk supercondyctors for practical applications.

Design of novel materials-based high performance magnetic gradiometer

Vývoj vysoko-citlivého magnetického gradiometra na báze nových magnetických materiálov

Duration: 1.4.2024 - 31.3.2027
Program: JRP
Project leader: RNDr. Škorvánek Ivan CSc.

Fundamentals and applications of purple bacteria biotechnology for resource recovery from waste

Základy a aplikácie purpurových baktérií v biotechnológií pre obnovu znečistených zdrojov

Duration: 10.10.2022 - 9.10.2026
Program: COST
Project leader: RNDr. Pudlák Michal CSc.
Annotation:PURPLEGAIN aims to create a European network to share information, facilitating technology and knowledge transfer between the academic and industrial sectors, related to PPB applications for resource recovery from organic waste sources. Resource recovery includes wastewater or organic waste, open or closed environments, in single or chain processes. The network associates fundamental-focused and applied-research groups, improving lab-scale technology optimization through mechanistic modeling. It benefits the technology transfer from applied-research groups to industry, considerably improving process design.

The total number of projects: 19