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The list of international projects SAS

Centre of Biosciences SAS
Application of thymol as feed additive in rabbit nutrition.
Aplikácia tymolu ako kŕmneho aditiva vo výžive králikov.
Program: Mobility
Project leader: MVDr. Plachá Iveta PhD
Annotation:Phytogenic feed additives enhance productivity through the improvement of digestibility, nutrient absorption and reduction of pathogens in the animal gut. Their beneficial properties particularly arise from their bioactive molecules (e.g. carvacrol, thymol, cineole, linalool). The phenolic OH group in thymol is responsible for its strong antioxidant properties which makes it attractive, and it has become a fashionable topic of research interest. Antimicrobial activity of thymol has been evidenced in many studies, thus a potential effect of their use in animal nutrition may be the reduction of antibiotic resistance in farms. The main problems for plant compounds are related to their poor bioavailability and low concentrations in target tissues. The present study provides new insights for understanding the possible processes of absorption and deposition of thymol, which could help to propose an appropriate dose for its application considering safety food.
Duration: 1.1.2021 - 31.12.2022
Bacteriocins and their benefits in reduction of spoilage, biofilm-producing bacteria from food products and food industry environment
Bakteriocíny a ich prospešnosť pri redukcii nežiaducich, biofilm-produkujúcich baktérií z potravín a z prostredia ich výroby
Program: Bilateral - other
Project leader: MVDr. Lauková Andrea CSc.
Annotation:Food safety but also hygiene and safety of food industry environment are of prime concern to both, industry and consumers. In fact food security depends on food safety and control of food spoilage. The most inspected regarding these aims are products of dairy and meat industry. In spite of the maintaining all ISO rules and HACCP rules, contamination can occur in the food chain from roducer to consumer and the consequence is a decrease of the product quality. At recent time, the frequent studies are related to problems with biofilm-producing bacteria; they are in biofilm which is protective for them; it means they are more resistant to survive. This project therefore will solve use and benefit of bacteriocins (antimicrobial substances produced by some bacteria) to reduce spoilage biofilm-producing bacteria from food and food industry environment.
Duration: 1.1.2019 - 31.12.2021
Bacteriocins, a safe way to inhibit antibiotic resistant bacteria from pigs for healthy farming
Bakteriocíny, bezpečný spôsob redukovania na antibiotiká rezistentné baktérie pre zachovanie zdravého chovu prasiat
Program: Bilateral - other
Project leader: MVDr. Lauková Andrea CSc.
Annotation:In Serbia, pigs production is related to commercial farms, family farms type A and B, backyard holding and free-range animals. The majority of farmers is facing with different health issues in herds, financial difficulties and not able to overcome the problems in the production. Their production strategies often rely to antimicrobial therapy. As a consequence, different groups od ATB have wide application at pig farms as prophylactic and therapeutic measure; it leads to the development of resitant microbiota in herd population. Antimicrobial resistance has emerged as major clinical and public health concern due to its negative effects reflected in prolonged, complicated therapy course and inadequate control of spreading resistant bacteria. That is necessary to find strategy how to reduce this atb pressure. One promising way how to stop/reduce ATb resistant bacteria represent bacteriocins. They are substances of proteinacoeus character with antimicrobial effect against more or less relative bacteria. In this project inhibition activity of bacteriocins/enterocins (produced by probiotic E. faecium strains from SK) against especially to ATB resistant coliforms isolated from pigs will be tested with the aim to find a new strategy to reduce antibiotic resistant strains in breeding. This is original and perspective method which brings benefit for both partners; for healthy farming and for study antimicrobial spectrum of enterocins.
Duration: 15.2.2019 - 31.12.2021
New diagnostic and therapeutic tools against multidrug resistant tumors
Nové diagnostické a terapeutické nástroje v liečbe mnoholiekovej rezistencie nádorov
Program: COST
Project leader: Mgr. Messingerová Lucia PhD.
Duration: 11.9.2018 - 10.9.2022
Pan-European Network in Lipidomics and Epilipidomics
Paneurópska sieť pre lipidomiku a epilipidomiku
Program: COST
Project leader: Mgr. Balážová Mária PhD.
Annotation:Lipids represent a wide variety of molecules that play different biological roles such as energy resources, structural components or signaling molecules that regulate metabolic homeostasis. Most notably, lipids and oxidatively modified lipids have been found to be involved in regulating important mechanisms mediating tissue injury, inflammation, and related non-communicable diseases, which are responsible for near 70% of all deaths in developed countries. Lipidomics and Epilipidomics are the most promising strategies for the progress in the knowledge of lipids, aiming at biomarker discovery for the prevention, early diagnosis, monitoring, evaluation of diseases therapeutics. These approaches involve the use of complex protocols, different instrumentation and processing huge amounts of data. Effectiveness, while reducing the high costs associated with these technologies, requires a harmonized multidisciplinary approach involving coordinated actions from pan-European centres of lipidomics investigation. This will avoid unnecessary redundancy, improving reproducibility and ensuring efficient and productive research. EpiLipidNET aims to build and maintain a multidisciplinary pan-European network of researchers, clinicians and enterprises working in the field of lipidomics and epilipidomics to boost a hub of research excellence, advanced knowledge and technology transfer, to promote high level of training for young researches and facilitate clinical translation. EpiLipidNet will include five interactive Working Groups covering analytical methods and computational approaches in (epi)Lipidomics, clinical significance and applications, lipid signaling and mechanisms of action, dissemination and outreach.
Duration: 13.10.2020 - 12.10.2024
Benefits of bacteriocins application in horse diet
Prospešnosť aplikácie bakteriocínov v diéte koní
Program: Inter-academic agreement
Project leader: MVDr. Lauková Andrea CSc.
Annotation:The aim of the project is to study the possible beneficial effect of enterocins on horse breeds in Slovakia/Poland. The natural substances (provided by the Slovak partner) will be used to maintain healthy conditions in horses. In the study microbiota, hematology, biochemistry, phagocytic and enzymatic/metabolic activity parameters will be analysed. In addition, it will be possible to isolate a new active bacteriocin from faecal samples of horses from Poland. The scientific area of the study is actual, only limited information is available regarding the horses microbiota and the effect of bacteriocins on the physiological parameters in those animals.The expected results will be the principal contribution to the knowledge of horses microbiota (also their welfare and health) which is still limited. Apart from enterocins analyses and their usefulness in horses we will perform detail sequencing of the faecal samples to distinguish microbiota profile from phyla to the species occurrence which will allow to extent the present knowledge in this field.
Duration: 1.1.2019 - 31.12.2022

The total number of projects: 6