RNDr. Petra Bonová, PhD.
The mechanisms of ischemic tolerance after stroke, investigating the role of blood cells and paracrine factors in neuroprotection.
Institute of Neurobiology
Dúbravská cesta 9
845 05 Bratislava
Slovak Republic
@:
Stroke kills over 6 million people annually and survivors face reduced quality of life. Most cases are ischemic, caused by blocked blood flow. In the ischemic core, cells die irreversibly, while the penumbra – tissue under milder ischemia – can survive if treated promptly. The balance between infarct expansion and penumbral survival defines brain damage and treatment success.
Although therapies have improved, their effectiveness is limited by early diagnosis and patient-specific factors (age, sex, comorbidities, body weight). This highlights the need for experimental strategies and personalized approaches. Our research focuses on:
- mechanisms of pathological transformation in ischemia-affected brain tissue,
- development and testing of neuroprotective strategies,
- identification of risk factors influencing therapy success to enable personalized treatment of stroke patients.
Although therapies have improved, their effectiveness is limited by early diagnosis and patient-specific factors (age, sex, comorbidities, body weight). This highlights the need for experimental strategies and personalized approaches. Our research focuses on:
- mechanisms of pathological transformation in ischemia-affected brain tissue,
- development and testing of neuroprotective strategies,
- identification of risk factors influencing therapy success to enable personalized treatment of stroke patients.