Centre of Biosciences SAS
Topic
Effects of low-frequency ultrasound in wounds treatment tested in Japanese quail CAM model
PhD. program
Animal Physiology
Year of admission
2026
Name of the supervisor
Mgr. Mariana Máčajová, PhD.
Contact:
Receiving school
Faculty of Natural Sciences of Comenius University in Bratislava
Annotation
Currently, the treatment of infected wounds is also a major challenge in medicine. At a time of increasing antibiotic resistance, alternative therapies are also coming into their own. In our project, we will create an in vivo model for the research and treatment of superficial infections. We will apply sonodynamic therapy using low-frequency ultrasound on a quail chorioallantoic membrane (CAM) model. Sonodynamic therapy is a therapeutic method that combines ultrasound with the use of substances called sonosensitizers. Similar to photodynamic therapy (PDT), which uses light to activate photosensitizers, sonodynamic therapy uses ultrasound to activate the active agents and improve their penetration into cells. After therapy, we will monitor angiogenic changes in CAM tissue, expression of selected genes, as well as histological and immunohistochemical changes.