Biomedical Research Center SAS
Topic
The role of protein kinases in the regulation of pre-mRNA splicing
PhD. program
biochemistry
Year of admission
2026
Name of the supervisor
Ing. Ľuboš Čipák, PhD.
Contact:
Receiving school
Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava
Annotation
Regulation of pre‑mRNA splicing represents a key step in gene expression. Although the basic mechanisms of splicing are well understood, the roles of many regulatory factors, particularly protein kinases, remain insufficiently studied. The aim of this dissertation will be to elucidate the biological functions of selected protein kinases in the regulation of splicing processes in the fission yeast S. pombe. The work will focus on identifying the substrates of these kinases, analyzing their impact on spliceosome dynamics, and characterizing the phenotypic consequences of disrupting their activity.