Centre of Experimental Medicine SAS
Topic
Impact of enhanced angiotensin 1–7 activity, the vasodilatory and natriuretic axis of the renin–angiotensin system, on pathological cardiac remodeling in combined heart failure and chronic kidney disease
PhD. program
Animal physiology
Year of admission
2026
Name of the supervisor
RNDr. Barbara Szeiffová Bačová, PhD.
Contact:
Receiving school
Faculty of Natural Sciences Comenius University
Annotation
Combined heart failure and chronic kidney disease represent a major medical challenge with high mortality rates, where the inadequacy of current treatments stems primarily from an incomplete understanding of the underlying pathophysiology. Activation of the protective vasodilatory and natriuretic angiotensin 1–7 (ANG 1–7) axis represents a potential mechanism for the mitigation of cardiorenal injury. The primary objective is to verify whether the TG7371 transgenic rat model exhibits increased activity of this axis and subsequently to determine if this overproduction of ANG 1–7 can effectively modulate pathological cardiac remodeling, a key determinant of disease progression. By investigating the pathophysiological pathways of extracellular matrix remodeling in both sexes under conditions of cardiorenal syndrome (induced by a combination of aorto-caval fistula and renal ablation), this study aims to provide a comprehensive understanding of the systemic effects of the ANG 1–7 axis and define its therapeutic potential.