Centre of Biosciences SAS
Topic
Polymeric nanoparticles carrying mRNA in the treatment of acute central nervous system injury and their biodegradation in the organism
PhD. program
Animal Physiology
Year of admission
2026
Name of the supervisor
RNDr. Katarína Ondáčová, PhD.
Contact:
Receiving school
Faculty of Natural Sciences of Comenius University in Bratislava
Annotation
Nanomedicine currently represents a significant therapeutic potential in the treatment of a wide range of diseases. Acute injury of the central nervous system (CNS) constitutes a serious medical and socio-economic problem, particularly due to the limited regenerative capacity of the CNS. The aim of this study is to investigate whether polymeric nanoparticles carrying mRNA encoding a specific protein, or alternatively a therapeutic compound itself, are capable of influencing the regeneration of damaged CNS tissue and to elucidate the mechanisms underlying these effects. Furthermore, the analysis of the biodegradation of polymeric nanoparticles will contribute to a better understanding of their biodistribution and behavior within the organism.