Biomedical Research Center SAS
Topic
Molecular-biological analysis of the mechanism of ischemic tolerance in atenuation the consequences of stroke by conditioning
PhD. program
zoology and animal physiology
Year of admission
2025
Name of the supervisor
RNDr. Rastislav Mucha, PhD.
Contact:
Receiving school
Faculty of Sciences, Pavol Jozef Šafárik University in Košice
Annotation
Annotation :
Understanding the mechanisms of neuroprotectivity activation after ischemic brain damage at the molecular level is necessary to understand this process. It is known that peripheral blood reflects changes in gene and protein expression in the brain very sensitively and specifically.
Aims:
1) To identify potential markers (genes, proteins) of ischemic tolerance activation.
2) To classify and specify genes and proteins in their signalling pathways and creating a reaction map of molecular cascades specific for the mechanism of ischemic tolerance in human blood samples and in a rat model.
Understanding the mechanisms of neuroprotectivity activation after ischemic brain damage at the molecular level is necessary to understand this process. It is known that peripheral blood reflects changes in gene and protein expression in the brain very sensitively and specifically.
Aims:
1) To identify potential markers (genes, proteins) of ischemic tolerance activation.
2) To classify and specify genes and proteins in their signalling pathways and creating a reaction map of molecular cascades specific for the mechanism of ischemic tolerance in human blood samples and in a rat model.