Biomedical Research Center SAS
Topic
In vitro assessment of the effects of a combination of phytochemicals and metal nanoparticles on gonadal somatic cells
PhD. program
biochemistry
Year of admission
2025
Name of the supervisor
Mgr. Soňa Scsuková, CSc.
Contact:
Receiving school
Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava
Annotation
The rapid development of nanotechnology has led to the production of innovative (nano)products and applications, but has also raised concerns about potential human exposure to nanoparticles (NPs) and their adverse health effects. Recently, new approaches increasing the NP biosafety are of great interest. The administration of phytochemicals with antioxidant and anti-inflammatory properties seems to provide a promising potential to mitigate the adverse effects of NPs on biological systems. The aim of the PhD thesis is to elucidate the molecular mechanisms (apoptosis, oxidative stress, inflammation) of the effects of selected metal NPs (silver, gold, copper) with different physicochemical properties (size, surface modification) in combination with phytochemicals on the functions of ovarian granulosa cells and testicular Leydig cells in vitro.