Biomedical Research Center SAS
Topic
Metabolic flaxibility as a marker of metabolic health: mechanisms and molecular predictors
PhD. program
animal physiology, biochemistry
Year of admission
2025
Name of the supervisor
Mgr. Jozef Ukropec, DrSc.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University in Bratislava
Annotation
Metabolic flexibility is an important determinant of the metabolic health with the capacity to modulate effectiveness of the adaptive response to exercise & lifestyle interventions.
Aim of this work is (i) to characterize clinical parameters and molecular biomarkers of metabolic flexibility expressed / released into systemic circulation in energetically challenging situations (exercise) and (ii) to determine effects of exercise derived factors (EVs) on proliferation, differentiation, and metabolic flexibility of human primary skeletal muscle cells and adipocytes.
Ultimately, we would like to define and validate metabolic flexibility- related biomarker with the capacity to predict response to a lifestyle intervention, providing personalised precision medicine for obesity related chronic diseases.
Aim of this work is (i) to characterize clinical parameters and molecular biomarkers of metabolic flexibility expressed / released into systemic circulation in energetically challenging situations (exercise) and (ii) to determine effects of exercise derived factors (EVs) on proliferation, differentiation, and metabolic flexibility of human primary skeletal muscle cells and adipocytes.
Ultimately, we would like to define and validate metabolic flexibility- related biomarker with the capacity to predict response to a lifestyle intervention, providing personalised precision medicine for obesity related chronic diseases.