The list of international projects SAS
Institute of Experimental Physics
The ALICE experiment at the CERN LHC: Study of the strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
| Duration: |
1.1.2022 - 31.12.2026 |
| Program: |
CERN |
| Project leader: |
RNDr. Králik Ivan CSc. |
| Annotation: | The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties. |
ATLAS experiment at LHC at CERN: deep-inelastic phenomenons and new physics at TEV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Discovery and Mechanism of Small Molecules from Traditional Chinese Herbs for Multitarget directed Therapy of Neurodegenerative Diseases
Identifikácia malých molekúl z tradičných čínskych bylín na multicieľovú terapiu neurodegenerat ívnych ochorení a objasnenie mechanizmu účinku
| Duration: |
1.7.2024 - 30.6.2026 |
| Program: |
Bilateral - other |
| Project leader: |
doc. RNDr. Gažová Zuzana DrSc. |
| Annotation: | Protein misfolding neurodegenerative diseases (NDDs), such as Alzheimer's and Parkinson's diseases, result in
extensive cellular and neuronal loss within the central nervous system. Despite the distinct manifestations of these
disorders, they share several common pathogenic mechanisms. Current pharmacological interventions are
ineffective. Moreover, the complexity of NDDs necessitates innovative therapeutic approaches. In this project, the
novel "multi-target-directed ligands" (MTDLs) strategy will be employed as it focuses on development of novel
compounds modulating multiple factors simultaneously. We will focus on Chinese herbs - Angelica sinensis,
Ligusticum chuanxiong, and Cinnamomum cassia. The project aims to explore the anti-aggregation potential of
these herbal extracts and their derivatives targeting both Aβ peptide and α -synuclein, showcasing neuroprotective
and anti-inflammatory properties to pave the way for the development of novel t herapeutic strategies for NDDs.
The project combines the expertise and experience of both research teams in the field of protein misfolding and
NDDs pathology, allowing us to acquire complex data with the aid of complementary approaches, leading to the
suggestion of possible alternatives of therapy against these devastating diseases. Moreover, this collaborative
research partnership will present an excellent opportunity for both teams' young members to learn new techniques
in the well-equipped laboratories at East China University and IEP SAS and gain new experience by working in an
international scientific environment. |
Laser Additive Manufacturing of Soft Ferromagnetic Metallic Glasses/ Composites
Laserová aditívna výroba magneticky mäkkých kovových skiel/kompozitov
Quiet Ionospheric Disturbances - REsearch based on Ground-based mesospheric and Ionospheric data with Swarm data
Narušenia pokojnej ionosféry - Výskum založený na pozemných meraniach mezosféry a ionosféry a na dátach z ESA misie SWARM
| Duration: |
1.2.2024 - 31.12.2026 |
| Program: |
European Space Agency (ESA) |
| Project leader: |
RNDr. Mackovjak Šimon PhD. |
| Annotation: | With this the QUID-REGIS project aims to improve the understanding of unexpected ionospheric variability during solar quiet periods. This is achieved by integrating data and knowledge of ionospheric variability with lower atmospheric dynamics. The project seeks to isolate the sources of variability and enhance comprehension of its underlying drivers by leveraging Swarm satellite data, ground-based airglow measurements, and the IRI model. Understanding these disturbances in the upper atmosphere has crucial implications for space weather forecasting and satellite communications, making QUID-REGIS a vital component of ongoing EO research. |
Non-globular proteins in the era of Machine Learning
Neglobulárne proteíny v ére strojového učenia
| Duration: |
25.10.2022 - 26.10.2026 |
| Program: |
COST |
| Project leader: |
RNDr. Bednáriková Zuzana PhD. |
| Annotation: | The ML4NGP Action aims to establish an interdisciplinary pan-European network to favour interplay between experiments and computation, fostering experimental frameworks designed to provide information to computational methods, and novel computational methods developed, trained and benchmarked with experimental data. ML4NGP will enhance the primary experimental data generation (WG1), promote integrative structural biology approaches (WG2), benchmark the state-of-the-art ML methods (WG3) and improve the functional characterization of NGPs (WG4). The Action will support its scientific objectives through policies that sustain free knowledge exchange, inclusiveness and training of young researchers who will lead future innovations in this field. |
Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases
Nové inhibítory amyloidnej agregácie na báze peptidov pre potenciálnu liečbu neurodegeneratívnych ochorení
| Duration: |
1.7.2025 - 30.6.2027 |
| Program: |
Bilateral - other |
| Project leader: |
RNDr. Bednáriková Zuzana PhD. |
| Annotation: | Neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by abnormal protein amyloid aggregation and subsequent neuronal loss. Current treatments provide limited efficacy, underscoring the urgent need for innovative strategies. This project proposes leveraging Late Embryogenesis Abundant Proteins (LEAPs) derived from resurrection plants as anti-aggregation agents for Amyloid β peptides and α-Synuclein, key proteins implicated in AD and PD. Our preliminary data demonstrate that LEAP candidates inhibit amyloid aggregation in vitro, validated through advanced spectroscopic and imaging techniques. We aim to recombinantly produce LEAPs, elucidate their binding mechanisms, and develop LEA-mimetic peptides with enhanced therapeutic potential. Employing in vitro assays and AD/PD-like C. elegans models, we will assess their anti-aggregation efficacy and cytotoxicity. This interdisciplinary collaboration integrates computational biology, biochemistry, and neurobiology to advance peptide-based therapies for neurodegenerative diseases. |
Fabrication and Characterization of Protein-based Hydrogels with Rapid 3D Imaging via Advanced Nonlinear Optical Microscopy
Príprava a charakterizácia proteínových hydrogélov s 3D zobrazovaním pomocou pokročilej nelineárnej optickej mikroskopie
| Duration: |
1.7.2025 - 30.6.2027 |
| Program: |
Bilateral - other |
| Project leader: |
RNDr., Ing. Šipošová Katarína PhD. |
| Annotation: | Proteins displaying remarkable structural and functional characteristics such as biocompatibility, biodegradability, abundance, and reduced ability to induce immune and tissue inflammatory responses possess great potential for the manufacture of hydrogels. In addition, all proteins have the potential to be cross-linked, therefore by employing physical, chemical, and enzymatic treatments, proteins have innate benefits for hydrogel-forming. Amyloidal proteins are a category of programmable self-assembled macromolecules, and their assembly and owing to the programmability of the self-assembly of amyloidal structures, the consequent nanostructure can be manipulated rationally. Moreover, self-assembly allows the co-assembly of two or more types of building blocks, resulting in increasingly structurally complex nano-assemblies that may have physical and chemical properties distinct from those of the original mono-structures. Therefore, in the crosslinking-controlled strategy, by changing the nature and concentration of proteins, the resulting physical-chemical properties of amyloid-inspired hydrogel can be rationally tuned. Motivated by this, the proposal is aimed at basic as well as applied research and is represented by two major goals: a) preparation of single (one)-type amyloid-based hydrogels; b) fabrication of mixed protein-hydrogels by entrapping DNA-protein hybrids that could lead to the developing new materials with unprecedented structural and functional features; (c) the application of advanced nonlinear optical microscopy for rapid 3D multiphoton fluorescence imaging and second harmonic generation imaging to investigate hydrogel structures; and (d) the integration of deep learning-based image enhancement techniques to improve 3D image quality and capture detailed structural information. |
Development of knowledge and technology to implement retrofilling in power ransformers using biodegradable or recycled fluids and fostering circular economy
Rozvoj znalostí a technológií na implementáciu dodatočného plnenia výkonových transformátorov s použitím biologicky odbúrateľných alebo recyklovaných kvapalín a podpora obehového hospodárstva
skQCI
skQCI
Investigation of Advanced Functional Materials based on Liquid Ctystals
Skúmanie pokročilých funkčných materiálov na báze kvapalných kryštálov
| Duration: |
1.1.2025 - 31.12.2028 |
| Program: |
Bilateral - other |
| Project leader: |
RNDr. Tomašovičová Natália CSc. |
| Annotation: | The widespread acquaintance of liquid crystals (LCs) is based on today’s liquid crystal display technology. There are also other important devices (less well known to the public) relying on LCs like optical switches, photo-elasticmodulators, tunable lasers, tunable filters, etc. These devices take the use of the anisotropy (orientational dependence) in the optical, electric and magnetic properties of LCs for functioning. The proposal focuses on the exploration of transitions induced by external fields in LCs doped with magnetic, non-magnetic and photothermal conversion nanoparticles as well as their mixture. Transitions under the scope include phase and orientational transitions of such composite systems. The proposal has the ultimate goal to exploit the transitions under the scope in potential practical devices such as various magnetic/electric/optical/thermal sensors & actuators, and energy-related LC devices like smart windows, no-bias optically-compensated bend LC displays, bistable bendsplay LC displays. |
Slovak contribution to ESA-JUICE mission: Development of Anti-Coincidence Module ACM for Particle Environment Package PEP
Slovenský príspevok k misii ESA-JUICE: Vývoj anti-koincidenčného modulu ACM pre časticový komplex PEP
| Duration: |
15.11.2018 - 31.12.2026 |
| Program: |
European Space Agency (ESA) |
| Project leader: |
Ing. Baláž Ján PhD. |
| Annotation: | The ESA’s JUICE (JUpiter ICy moons Explorer) mission (http://sci.esa.int/juice) have to face to very hostile environment of Jovian radiation belts where the penetrating energetic electrons dominate. The Particle Environment Package (PEP) payload of this mission (http://sci.esa.int/juice/50073-science-payload ) was developed within a wide international collaboration led by Swedish Institute for Space Physics IRF in Kiruna. Due to limited available mass for efficient radiation shielding, the PEP payload will operate in rather unfavourable environment of penetrating energetic electrons that will affect the detection process inside the PEP/JDC (Jovian plasma Dynamics and Composition) sensor. To mitigate the unfavourable influence of the penetrating electron radiation to the plasma ions detection process, a concept of anti-coincidence module (ACM) has been identified within the PEP consortium. The project involves development of space-flight grade semiconductor solid state detector, the processing electronic board and a laboratory testing and calibration system RATEX-J (RAdiation Test EXperiment for JUICE). The JUICE probe has been successfully launched 14.4.2023 from space port Kourou. The PEP science suite has been successfuly commissioned in June 2023. The JUICE probe will be inserted into the orbit around Jupiter on 18. July 2031.
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Superfluid Condensates in Astrophysics and Laboratory Experiments
Superfluid Condensates in Astrophysics and Laboratory Experiments
SUPERCONDUCTING NANODEVICES AND QUANTUM MATERIALS FOR COHERENT MANIPULATION
Supravodivé nanozariadenia a kvantové materiály pre koherentnú manipuláciu
| Duration: |
6.10.2022 - 5.10.2026 |
| Program: |
COST |
| Project leader: |
prof. RNDr. Samuely Peter DrSc., akademik US Slovenska |
| Annotation: | We propose a collaborative approach joining
together efforts and groups all over Europe, structured around three pathways, (i) the synthesis and
characterization of quantum materials with novel topological properties, (ii) the fabrication of sensors and
devices exploiting novel superconducting functionalities and (iii) the generation and coherent manipulation of
superconducting states that can create new opportunities in the superconducting quantum electronics. Using
an open and inclusive approach that joins expertise and capabilities all over Europe, this project will structure
collaborative efforts aiming at disruptive achievements in the field of superconductivity. The results will
impact far beyond the development of new quantum solutions for computation, and include sectors such as
health and energy. |
Exploring Protein Amyloid Superstructures and Dynamics Using Single-Molecule Microscopy with the Deep-Learning Modeling
Štúdium štruktúry a dynamiky supramolekulárnych amyloidných štruktúr jednomolekulovou mikroskopiou a modelovaním pomocou strojového učenia
| Duration: |
1.1.2025 - 31.12.2027 |
| Program: |
JRP |
| Project leader: |
RNDr., Ing. Šipošová Katarína PhD. |
| Annotation: | Protein self-assembly processes independent of external energy sources and unlimited in-dimensional scaling have become a very promising approach for developing new materials with unprecedented structural and functional features. The best examples of self-assembled materials can be found in nature, including functional and pathological amyloid fibrils. Motivated by this, the proposal is aimed at basic as well as applied research and is represented by two major goals: a) anti-amyloid study - focusing on pathological amyloid aggregation connected with neurodegenerative diseases that will optimize the application of newly prepared compounds/particles in the treatment of amyloid-related diseases and enable imaging of amyloid formation/decomposition; b) fabrication of protein superstructures by chemical appending of functional ligands onto self-assembling peptides or proteins lays the foundation for developing new materials with unprecedented structural and functional features.
Therefore, the development of the single-molecule orientation and localization microscopy (SMOLM), together with the deep-learning modeling for the localization and reconstruction of SMOLM images will help rapidly perfect the high-content analysis of the structural-morphological features not only the pathological amyloid aggregates but also superstructures consisting of amyloid scaffolds and connected bio-structures (DNA) and ligands. Moreover, the single-molecule orientation and localization microscopy could significantly contribute to understanding not only the process of protein self-assembly but also the mechanism of the binding and release of biologically active agents, formation and reorganization of multiple protein arrangements upon interaction with biologically relevant ligands/molecules.
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Topologický riadené samousporiadanie a nové multiferoické kvapaliny
| Duration: |
1.1.2025 - 31.12.2026 |
| Program: |
Inter-academic agreement |
| Project leader: |
RNDr. Tomašovičová Natália CSc. |
| Annotation: | The proposal offers research on colloidal systems from the perspective of self-assembly (SA), where a form of overall order arises due to the local interactions between the components of an initially disordered system. SA has an indisputable importance in all fields of natural sciences, and has also a deep impact in social sciences (economics, sociology, anthropology, psychology, etc).
Currently, one of the hot topics of the worldwide research is to design nanomaterials that are capable to assemble into functional superstructures in multiple directions. Besides the local ordering appearing spontaneously on the molecular level of SA materials, they may form micro/macroscopic superstructures via the appearance of topological defects (TDs). These local singularities are universal in nature, having great importance in many fields including cosmology, nanophysics, materials science, and particle physics. TDs can trigger phase transitions, attract/repulse each other, and trap foreign objects (particles). At the same time, particles dispersed in a SA matrix inevitably generate TDs around themselves. Therefore, in colloidal systems, a subtle interplay between micro/nano-particles, SA matrix and TDs drives the self-organization process. In line with the TD driven SA investigations, the discovery of ferroelectric nematic phase (NF) in 2017 offers the possibility to create novel multiferroic liquids by doping NF with nanoparticles, which we also intend to explore.
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The role of cosmic rays in clouds formation
Úloha kozmického žiarenia vo formovaní mrakov
Research on bulk superconductors
Výskum masívnych supravodičov
| Duration: |
1.5.2018 - 31.12.2026 |
| Program: |
Other |
| Project leader: |
Ing. Diko Pavel DrSc., akademik US Slovenska |
| Annotation: | The agreement on cooperation between IEP SAS and CAN Superconductorsis focused on research od REBCO bulk supercondyctors for practical applications. |
Design of novel materials-based high performance magnetic gradiometer
Vývoj vysoko-citlivého magnetického gradiometra na báze nových magnetických materiálov
Fundamentals and applications of purple bacteria biotechnology for resource recovery from waste
Základy a aplikácie purpurových baktérií v biotechnológií pre obnovu znečistených zdrojov
| Duration: |
10.10.2022 - 9.10.2026 |
| Program: |
COST |
| Project leader: |
RNDr. Pudlák Michal CSc. |
| Annotation: | PURPLEGAIN aims to create a European network to share information, facilitating technology and knowledge transfer between the academic and industrial sectors, related to PPB applications for resource recovery from organic waste sources. Resource recovery includes wastewater or organic waste, open or closed environments, in single or chain processes. The network associates fundamental-focused and applied-research groups, improving lab-scale technology optimization through mechanistic modeling. It benefits the technology transfer from applied-research groups to industry, considerably improving process design. |
Magnetic Particle Imaging for next-generation theranostics and medical research
Zobrazovanie magnetických častíc pre teranostiku novej generácie a medicínsky výskum
The total number of projects: 21
