The list of international projects SAS
Institute of Experimental Physics
Inhibition of A-beta Peptides Aggregation by Late Embryogenesis Abundant Proteins: A New Approach for Alzheimer’s Disease Treatment
Inhibícia agregácie A-beta peptidov proteínmi vyskytujúcimi sa počas neskorej embryogenézy: nový prístup liečby Alzheimerovej choroby
| Duration: |
1.4.2024 - 31.12.2025 |
| Program: |
Bilateral - other |
| Project leader: |
RNDr. Bednáriková Zuzana PhD. |
| Annotation: | Alzheimer’s disease (AD) is the most common neurodegenerative disorder, sharing unclear pathophysiology and massive social costs. Today, more than 55 million people have been diagnosed with AD, which is forecast to increase more than twice by 2050. AD is tightly associated with the formation of deposits containing amyloid β (Aβ) peptide organized into insoluble amyloid fibrils. Despite numerous contemporary studies focused on reducing Aβ aggregation, a cure for AD has not yet been found. Our project intends to implement the elements of molecular mechanisms underlying the remarkable phenomenon of plant desiccation tolerance and develop a new Aβ anti-aggregation strategy. Late Embryogenesis Abundant proteins (LEAPs) are markedly induced upon desiccation and can stabilize the native structure of proteins and membranes by a mechanism that is not fully understood. The primary project aim is to investigate the structural properties of Ramonda serbica LEAPs and their interactions with Aβ peptides and aggregation. Firstly, we will recombinantly produce LEAPs with the highest potential to inhibit Aβ aggregation. Further, we will analyze LEAPs’ secondary structure under different conditions, focusing on their order-to-disorder transitions. The final aim is to identify Aβ/LEAPs interactions and assess the Aβ anti-aggregation potential of LEAPs in vitro, which will impact the development of new strategies for AD treatment. The collaborating teams involved in this project (Slovak - IEP SAS and Serbian - IMGGE) were selected based on their expertise in protein production, protein structure analysis and amyloid aggregation. The expertise transfer between partner laboratories will be ensured by mutual training of PhD and postdoc researchers involved in the project. |
Development of knowledge and technology to implement retrofilling in power ransformers using biodegradable or recycled fluids and fostering circular economy
Development of knowledge and technology to implement retrofilling in power ransformers using biodegradable or recycled fluids and fostering circular economy
The ALICE experiment at the CERN LHC: Study of the strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
| Duration: |
1.1.2022 - 31.12.2026 |
| Program: |
CERN |
| Project leader: |
RNDr. Králik Ivan CSc. |
| Annotation: | The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties. |
ATLAS experiment at LHC at CERN: deep-inelastic phenomenons and new physics at TEV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Frustrated quantum magnets - impact of uniaxial pressure
Frustrované kvantové magnety - vplyv jednoosového tlaku
Hybrid DNA-functionalized fibrils as nanostructured material for bioanalytical applications
Hybrid DNA-functionalized fibrils as nanostructured material for bioanalytical applications
Discovery and Mechanism of Small Molecules from Traditional Chinese Herbs for Multitarget directed Therapy of Neurodegenerative Diseases
Identifikácia malých molekúl z tradičných čínskych bylín na multicieľovú terapiu neurodegenerat ívnych ochorení a objasnenie mechanizmu účinku
| Duration: |
1.7.2024 - 30.6.2026 |
| Program: |
Bilateral - other |
| Project leader: |
doc. RNDr. Gažová Zuzana DrSc. |
| Annotation: | Protein misfolding neurodegenerative diseases (NDDs), such as Alzheimer's and Parkinson's diseases, result in
extensive cellular and neuronal loss within the central nervous system. Despite the distinct manifestations of these
disorders, they share several common pathogenic mechanisms. Current pharmacological interventions are
ineffective. Moreover, the complexity of NDDs necessitates innovative therapeutic approaches. In this project, the
novel "multi-target-directed ligands" (MTDLs) strategy will be employed as it focuses on development of novel
compounds modulating multiple factors simultaneously. We will focus on Chinese herbs - Angelica sinensis,
Ligusticum chuanxiong, and Cinnamomum cassia. The project aims to explore the anti-aggregation potential of
these herbal extracts and their derivatives targeting both Aβ peptide and α -synuclein, showcasing neuroprotective
and anti-inflammatory properties to pave the way for the development of novel t herapeutic strategies for NDDs.
The project combines the expertise and experience of both research teams in the field of protein misfolding and
NDDs pathology, allowing us to acquire complex data with the aid of complementary approaches, leading to the
suggestion of possible alternatives of therapy against these devastating diseases. Moreover, this collaborative
research partnership will present an excellent opportunity for both teams' young members to learn new techniques
in the well-equipped laboratories at East China University and IEP SAS and gain new experience by working in an
international scientific environment. |
Laser Additive Manufacturing of Soft Ferromagnetic Metallic Glasses/ Composites
Laserová aditívna výroba magneticky mäkkých kovových skiel/kompozitov
Quiet Ionospheric Disturbances - REsearch based on Ground-based mesospheric and Ionospheric data with Swarm data
Narušenia pokojnej ionosféry - Výskum založený na pozemných meraniach mezosféry a ionosféry a na dátach z ESA misie SWARM
Non-globular proteins in the era of Machine Learning
Neglobulárne proteíny v ére strojového učenia
| Duration: |
25.10.2022 - 26.10.2026 |
| Program: |
COST |
| Project leader: |
RNDr. Bednáriková Zuzana PhD. |
| Annotation: | The ML4NGP Action aims to establish an interdisciplinary pan-European network to favour interplay between experiments and computation, fostering experimental frameworks designed to provide information to computational methods, and novel computational methods developed, trained and benchmarked with experimental data. ML4NGP will enhance the primary experimental data generation (WG1), promote integrative structural biology approaches (WG2), benchmark the state-of-the-art ML methods (WG3) and improve the functional characterization of NGPs (WG4). The Action will support its scientific objectives through policies that sustain free knowledge exchange, inclusiveness and training of young researchers who will lead future innovations in this field. |
Slovak contribution to ESA-JUICE mission: Development of Anti-Coincidence Module ACM for Particle Environment Package PEP
Slovenský príspevok k misii ESA-JUICE: Vývoj anti-koincidenčného modulu ACM pre časticový komplex PEP
| Duration: |
15.11.2018 - 31.12.2026 |
| Program: |
European Space Agency (ESA) |
| Project leader: |
Ing. Baláž Ján PhD. |
| Annotation: | The ESA’s JUICE (JUpiter ICy moons Explorer) mission (http://sci.esa.int/juice) have to face to very hostile environment of Jovian radiation belts where the penetrating energetic electrons dominate. The Particle Environment Package (PEP) payload of this mission (http://sci.esa.int/juice/50073-science-payload ) was developed within a wide international collaboration led by Swedish Institute for Space Physics IRF in Kiruna. Due to limited available mass for efficient radiation shielding, the PEP payload will operate in rather unfavourable environment of penetrating energetic electrons that will affect the detection process inside the PEP/JDC (Jovian plasma Dynamics and Composition) sensor. To mitigate the unfavourable influence of the penetrating electron radiation to the plasma ions detection process, a concept of anti-coincidence module (ACM) has been identified within the PEP consortium. The project involves development of space-flight grade semiconductor solid state detector, the processing electronic board and a laboratory testing and calibration system RATEX-J (RAdiation Test EXperiment for JUICE). The JUICE probe has been successfully launched 14.4.2023 from space port Kourou. The PEP science suite has been successfuly commissioned in June 2023. The JUICE probe will be inserted into the orbit around Jupiter on 18. July 2031.
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SUPERCONDUCTING NANODEVICES AND QUANTUM MATERIALS FOR COHERENT MANIPULATION
Supravodivé nanozariadenia a kvantové materiály pre koherentnú manipuláciu
| Duration: |
6.10.2022 - 5.10.2026 |
| Program: |
COST |
| Project leader: |
prof. RNDr. Samuely Peter DrSc., akademik US Slovenska |
| Annotation: | We propose a collaborative approach joining
together efforts and groups all over Europe, structured around three pathways, (i) the synthesis and
characterization of quantum materials with novel topological properties, (ii) the fabrication of sensors and
devices exploiting novel superconducting functionalities and (iii) the generation and coherent manipulation of
superconducting states that can create new opportunities in the superconducting quantum electronics. Using
an open and inclusive approach that joins expertise and capabilities all over Europe, this project will structure
collaborative efforts aiming at disruptive achievements in the field of superconductivity. The results will
impact far beyond the development of new quantum solutions for computation, and include sectors such as
health and energy. |
Study toward enhancing reliability and timeliness of Vigil mission predictions through Machine Learning
Štúdia smerujúca k zvýšeniu spoľahlivosti a včasnosti predikcií z dát misie Vigil pomocou strojového učenia
Ultrasound- and Magnetic-induced Hyperthermia as a Treatment Modality for Amyloid-related Diseases
Ultrazvukom a magneticky indukovaná hypertermia ako liečebná modalita pre amyloidné ochorenia
| Duration: |
1.1.2024 - 31.12.2025 |
| Program: |
Bilateral - other |
| Project leader: |
RNDr., Ing. Šipošová Katarína PhD. |
| Annotation: | Nanoparticles (NPs), including those with magnetic properties, have attracted significant scientific interest due to
their applications in various fields of science and medicine. As a consequence, several promising treatment
procedures have been developed, such as controlled and local drug delivery and release, photo- and sonodynamic
therapy, and thermal therapy. NPs can also be used as biosensors or imaging contrast agents. Additionally, they
are being studied for their potential role in amyloidogenic diseases. Although great efforts have been made to
understand the pathogenesis of these diseases and design effective therapy, there is still no treatment for amyloid -
related diseases. A possible alternative non-pharmacological option for targeting cross -
using energy generated by magnetic NPs as a result of applied magnetic field and/or ultrasound to disrupt large
amyloid structures (plaques) into smaller fragments. This proposal is aimed at basic as well as applied research
that will help perfect the application of magnetic NPs in the treatment of amyloid-related diseases via thermal and
ultrasound-induced processes and enable tomography imaging of amyloid formation/decomposition. Efficacious
drug/NPs deposition in the target site and operated activation of therapeutic and imaging agents reduce treatment
time, while avoiding adverse damage and side effects resulting from systemic administration. The collaboration will
not only promote the bilateral exchange of knowledge, technology and experience, but also may accelerate the
translation between biophysical/biochemical science and clinical study. |
Research on bulk superconductors
Výskum masívnych supravodičov
| Duration: |
1.5.2018 - 31.12.2026 |
| Program: |
Other |
| Project leader: |
Ing. Diko Pavel DrSc., akademik US Slovenska |
| Annotation: | The agreement on cooperation between IEP SAS and CAN Superconductorsis focused on research od REBCO bulk supercondyctors for practical applications. |
Development of SCSS-Net: Solar Corona Structures Segmentation algorithm by deep neural networks
Vývoj SCSS-Net: Algoritmus na segmentovanie štruktúr slnečnej koróny pomocou hlbokých neurónových sieti
Design of novel materials-based high performance magnetic gradiometer
Vývoj vysoko-citlivého magnetického gradiometra na báze nových magnetických materiálov
Fundamentals and applications of purple bacteria biotechnology for resource recovery from waste
Základy a aplikácie purpurových baktérií v biotechnológií pre obnovu znečistených zdrojov
| Duration: |
10.10.2022 - 9.10.2026 |
| Program: |
COST |
| Project leader: |
RNDr. Pudlák Michal CSc. |
| Annotation: | PURPLEGAIN aims to create a European network to share information, facilitating technology and knowledge transfer between the academic and industrial sectors, related to PPB applications for resource recovery from organic waste sources. Resource recovery includes wastewater or organic waste, open or closed environments, in single or chain processes. The network associates fundamental-focused and applied-research groups, improving lab-scale technology optimization through mechanistic modeling. It benefits the technology transfer from applied-research groups to industry, considerably improving process design. |
Magnetic Particle Imaging for next-generation theranostics and medical research
Zobrazovanie magnetických častíc pre teranostiku novej generácie a medicínsky výskum
The total number of projects: 19
