The list of international projects SAS
Centre of Experimental Medicine SAS
3Rs concepts to improve the quality of biomedical science (IMPROVE)
3Rs koncepty pre zlepšenie kvality biomedicínskych vied (IMPROVE)
| Duration: |
21.10.2022 - 20.10.2026 |
| Program: |
COST |
| Project leader: |
Dr.rer.nat., Ing. Kanďárová Helena ERT |
| Annotation: | Awareness of the existence of a reproducibility and predictability crisis in biomedical science has increased in recent years. The reproducibility crisis refers to the problem that researchers struggle to replicate or reproduce scientific studies. There has been many publications reviewing why preclinical research is irreproducible and lack of predictability, pointing this to deficiencies in reporting and statistical practices. Confounding factors, which are part of the laboratory environment and will influence both the dependent and independent variables, continue to be identified, suggesting that our knowledge of their existence is far from complete. Better statistical methodology will play a central role in improving the reproducibility of science to produce robust and reproducible research. Another area of improvement is the development of novel methods to better define and assess replication success and improve predictability. Under this light, the development and introduction of new, powerful concepts for biomedical research is essential to reduce the production of non-reproducible and non-predictive data. This has immense scientific, economic and social significance. In this context, we propose that the findings and concepts from the 3Rs field can greatly help to improve biomedical research on several levels.
Therefore, the main aim of the COST Action IMPROVE is:
To establish a network which will work to refine, harmonise and promote 3Rs concepts, data and documents, in order to improve the quality of biomedical science. |
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Efekty inhibítorov sodíkovo-glukózového transportéru 2 a kvercetínu, prírodného antioxidantu na myokardiálne ischemicko-reperfúzne poškodenie po kardioplégii
Európska sieť pre biológiu rezolúcie zápalu (EU-RESOLVE)
EU-Resolution Biology Network (EU-RESOLVE)
| Duration: |
15.10.2026 - 14.10.2029 |
| Program: |
COST |
| Project leader: |
doc. RNDr. Pecháňová Oľga DrSc. |
| Annotation: | EU-RESOLVE aims to create a multidisciplinary, pan-European network of excellence in Resolution Biology. This network will bring together academics, clinicians, biotechnology companies, and other stakeholders. EU-RESOLVE will advance the understanding of the mechanisms that regulate the resolution of inflammation and accelerate the translation of these findings into more effective treatments for patients with inflammatory diseases. |
Engineering novel 3D organotypic skin models
European Network for Skin Engineering and Modeling (NETSKINMODELS)
| Duration: |
15.9.2022 - 14.9.2026 |
| Program: |
COST |
| Project leader: |
Dr.rer.nat., Ing. Kanďárová Helena ERT |
| Annotation: | Over the past years, investigative and experimental dermatology has developed various approaches, ranging from utilisation of ex-vivo skin tissues to establishment of reconstructed in-vitro and in-silico skin models as tools in both basic and translational skin research. These models have the strong potential to increase the significance of scientific and clinical outcomes and to reduce animal experimentation. Nevertheless, current skin models lack sophistication and standardisation, thereby hampering their wider acceptance by the scientific community and regulatory bodies. This is partly caused by a lack of cross talk between relevant stakeholders — regulatory bodies, basic scientists, clinicians, and industry — whereby advances in new technologies have not delivered their full potential in this field.
In the proposed Action, interdisciplinary and intersectoral research and coordinated initiatives will drive the development and validation of standout sophisticated cell-based and computational skin models, including the development of artificial intelligence models for dermatological research. Furthermore, the Action has ambitions to develop ethical and sustainable reagents required for the elaboration of organotypic skin models, based on a strong partnership between network academia and industries. Harmonisation of scientific and technological knowledge and an enduring bottom-up dynamic in the field will be ensured by dissemination of leading-edge know-how among research intensive and research moderate European territories. Moreover, next-generation scientists will be trained for the long-term propagation and continued development of skin models. Action outcomes will turbocharge the field of skin models to meet rising scientific, clinical, economic, environmental and regulatory expectations, making Europe the epicentre of research in this field. |
European Network for diagnosis and treatment of antibiotic-resistant bacterial infections
Európska sieť na diagnózu a liečbu bakteriálnych ochorení rezistentných voči antibiotikám
| Duration: |
6.10.2022 - 5.10.2026 |
| Program: |
COST |
| Project leader: |
RNDr. Májeková Magdaléna PhD. |
| Annotation: | The emergence and spread of drug-resistant bacteria is an important health and socioeconomic threat with global dimensions, which is developing towards an emergency/pandemic crisis. No drugs are available to address the disease, and diagnostic tools are poorly effective. This negatively impacts the treatment and survival of critically ill patients. Current research in this field is highly fragmented and mostly monodisciplinary, thus limiting the development of innovative diagnostic and therapeutic solutions. This COST Action will bring together industrial and academic European scientists with different skills and expertise in a multidisciplinary and concerted initiative. The Action will combine scientific disciplines in understanding the genetic and molecular bases of bacterial drug resistance, developing innovative diagnostic tools, and delivering lead/pre-clinical candidates, antibody-based therapies, and clinical-ready repurposed drugs towards the personalized treatment of drug-resistant bacterial infections. The further challenge of the Action is to enhance networking among European scientists and to train a new generation of young scientists skilled in the multiple aspects related to bacterial drug resistance. |
EUropean network to tackle METAbolic alterations in HEART failure
Európska sieť na riešenie metabolických zmien pri zlyhaní srdca
Reward-stress interactions as neurobiological substrate for resilience and vulnerability in mental health and depression: A translational large-scale project
Interakcia medzi odmenou a stresom ako neurobiologický podklad odolnosti a rezistencie v duševnom zdraví a depresii: Rozsiahly translačný projekt
ONTOX - Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
ONTOX - Testovanie opakovanej toxicity chemických látok na základe ontológie a umelej inteligencie za účelom hodnotenia rizík metódami NGRA
| Duration: |
1.5.2021 - 31.10.2026 |
| Program: |
Horizon 2020 |
| Project leader: |
Dr.rer.nat., Ing. Kanďárová Helena ERT |
| Annotation: | The vision of the ONTOX project is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next-generation risk assessment. Specifically, ONTOX will deliver a generic strategy to create innovative new approach methodologies (NAMs) in order to predict systemic repeated dose toxicity effects that, upon the combination with tailored exposure assessment, will enable human risk assessment.
This strategy can be applied to any type of chemical and systemic repeated dose toxicity effect. However, for proof-of-concept purposes, focus will be put on 6 specific NAMs addressing adversities in the liver (steatosis and cholestasis), kidneys (tubular necrosis and crystallopathy) and developing brain (neural tube closure and cognitive function defects) induced by a variety of chemicals, including from the pharmaceutical, cosmetics, food and biocide sectors.
The 6 NAMs will each consist of a computational system based on cutting-edge artificial intelligence (AI) and will be primarily fed by available biological/mechanistic, toxicological/ epidemiological, physico-chemical and kinetic data. Data will be consecutively integrated in physiological maps, quantitative adverse outcome pathway networks and ontology frameworks. Data gaps, as identified by AI, will be filled by targeted state-of-the-art in vitro and in silico testing.
The 6 NAMs will be evaluated and applied in collaboration with industrial and regulatory stakeholders in order to maximise end-user acceptance and regulatory confidence. This is anticipated to expedite implementation in risk assessment practice and to facilitate commercialisation. ONTOX will have a deep and long-lasting impact at many levels, in particular by consolidating Europe's world-leading position regarding the development, exploitation, regulation and application of animal-free methods for human risk assessment of chemicals.
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Bridging the gap between cardiac and vascular regeneration
Preklenutie medzery medzi srdcovou a cievnou regeneráciou
| Duration: |
1.1.2024 - 31.12.2026 |
| Program: |
Horizon Europe |
| Project leader: |
doc. RNDr. Barteková Monika DrSc. |
| Annotation: | Our project has the ambition to develop innovative therapies based on RNA to simultaneously induce the regeneration of the muscular and vascular components of the heart after cardiac damage. Toward this goal, we will explore two hypotheses. The first hypothesis is that the regeneration of the muscular component in sufficient to trigger re-vascularization. The second hypothesis is that the two processes, the regeneration of the cardiac muscle and its blood vessels, need to be stimulated in parallel to achieve functional regeneration of the heart. Whatever the mechanism, our project will develop novel RNA drugs, encapsulated into lipid nanoparticles, able to simultaneously trigger the regeneration of the cardiac muscle and its effective vascularisation. |
Natural compounds against rheumatoid arthritis and its comorbidities, focus on prevention of blood–brain barrier disfunction
Prírodné látky pre terapiu reumatoidnej artritídy a jej komorbidít so zameraním na disfunkciu hematoencefalickej bariery
| Duration: |
1.1.2025 - 31.12.2026 |
| Program: |
Bilateral - other |
| Project leader: |
PharmDr. Bauerová Katarína PhD., DrSc. |
| Annotation: | We will study the effect of selected natural compounds from different sources and different molecular structures on arthritic symptoms of RA and on extra-arthritic events, focusing on BBB dysfunction and neuroinflammation. Our attention will focus on compounds not yet considered as potential adjuvant agents for RA treatment and that, accordingly with detailed literature research, may potentially act against RA and/or neuroinflammation
Within the context of this project the SAS team will carry out the in vivo studies by using adjuvant arthritis model necessary to verify the effectiveness of the natural compounds selected in vitro by CNR colleagues. The SAS team will also carry out the assessment of specific inflammatory markers in plasma and in joint and spleen tissue samples. The SAS team will provide brain samples for CNR team. Further also NMR measurements in vivo will be done together with behavioral testing. |
Exploration of toxicology properties of drug candidates with antimicrobial and antiviral properties.
Skúmanie toxikologických vlastností kandidátov liečiv s antimikrobiálnymi a antivírusovými vlastnosťami
| Duration: |
1.9.2024 - 31.12.2026 |
| Program: |
Multilateral - other |
| Project leader: |
Dr.rer.nat., Ing. Kanďárová Helena ERT |
| Annotation: | The project focuses on exploring the toxicological properties of compounds with potential applications in the treatment of COVID-19. In vitro models of lung, nasal, and alveolar tissues will be employed to assess the safety and efficacy of drug candidates. This approach supports the development of novel therapeutic options while adhering to the principles of alternative testing methods. |
Validation of a Vaginal Irritation Protocol for the In Vitro Assessment of Medical Devices
Validácia protokolu vaginálnej iritácie pre hodnotenie zdravotníckych pomôcok in vitro
| Duration: |
1.12.2024 - 31.12.2026 |
| Program: |
Multilateral - other |
| Project leader: |
Dr.rer.nat., Ing. Kanďárová Helena ERT |
| Annotation: | The project aims to validate a reconstructed human vaginal model for in vitro testing of personal care products intended for use in the vaginal area. The results will be submitted to the ISO committee for potential implementation into the ISO 10993-23 standard, advancing safety assessment methodologies and promoting alternative testing approaches. |
Developing new miRNA therapeutics for cardioprotection
Vývoj nových miRNA terapeutík pre kardioprotekciu
| Duration: |
1.7.2025 - 30.6.2027 |
| Program: |
Bilateral - other |
| Project leader: |
doc. RNDr. Barteková Monika DrSc. |
| Annotation: | Myocardial infarction (MI) is a top cause of mortality and disability worldwide. Despite the golden standard for the
treatment of MI by timely reperfusion by the means of primary percutaneous coronary intervention (pPCI) saves lot
of lives post-MI, there is still no cardioprotective compound on the market that could effectively prevent the
consequences of MI or improve the effectiveness of reperfusion. Thus searching for the novel cardioprotective
compounds is very much needed. Micro RNAs (miRNAs) are small non-coding RNA molecules that play a
significant role in gene transcription regulation and have been found to play a role in the MI. Some of miRNAs have
been reported to be involved in the development of the heart injury in MI, others have been identified as
"protectomiRs", i.e., miRNAs with cardioprotective potential in MI. Based on these findings there is an extensive
research in the field of developing miRNA-based therapeutics for cardioprotection. In line with this trend, the
current project is aimed to identify the most efficient miRNAs for cardioprotection against MI-induced heart injury
and to optimize the mode of delivery of these protectomiRs to the heart by searching the optimal carriers or
vehicles for their application. |
The total number of projects: 13
